The Influence of Serum Immunoglobulin Concentration on Measles Antibody Level

Phillips, Peter; Christian, Charles L.

doi:10.3181/00379727-140-36670

Cited by 15 publications

(4 citation statements)

References 8 publications

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“…Another is that the local antibody synthesis is related to an immunological aberration associated with an activation of antibody-producing cell clones, without the presence of specific viral immunogens. A general activation of antibody-producing cells may be the reason for the elevated levels of measles antibodies in patients with SLE (19). The measles antibodies isolated from two SLH patients' sera in the present study were, however, electrophoretically heterogeneous.…”

Section: Discussioncontrasting

confidence: 45%

Oligoclonal Measles Virus‐Specific IgG Antibodies Isolated from Cerebrospinal Fluids, Brain Extracts, and Sera from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

et al. 1976

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Measles virus-specific antibodies were isolated from sera, cerebrospinal fluids (CSF), and brain extracts of patients with subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) by absorption with measles antigens and subsequent acid elution of the antigen-antibody precipitates. Electrophoretically homogeneous measles antibodies were isolated from CSF or brain extracts in five patients with SSPE and in five out of seven patients with MS. Homogeneous IgG antibodies were also demonstrated in the sera from all SSPE patients and from three of the MS patients. The antibodies isolated from various control sera and from pooled CSF were electrophoretically heterogeneous. The results support the concept of a local synthesis in the nervous system of oligoclonal IgG antibodies to measles virus in all patients with SSPE and in some patients with MS. In SSPE, most or all oligoclonal IgG proteins of the CSF or brain carry measles antibody activities. In MS, only part of the oligoclonal IgG appears to be associated with measles antibody activity.

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Section: Discussioncontrasting

confidence: 45%

Oligoclonal Measles Virus‐Specific IgG Antibodies Isolated from Cerebrospinal Fluids, Brain Extracts, and Sera from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

et al. 1976

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“…Most of the studies concern measles virus since Adams and Imagawa [21] first reported a high ser um antibody to this virus. A review of these studies, however, failed to reveal any rela tionship between measles antibody titer and disease activity or duration [22], Some au thors believe that the elevated antibody ti ters may be due to a hyperreactive immune system [23,24], Antiviral antibodies have al so been found in cerebrospinal fluid of MS patients [25]. Schuller et al [26] demonstrat ed the simultaneous presence of antibodies to nucleic acids and viral antigens in the CSF and sera of patients with MS.…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and Bullous Pemphigoid

Simjee

Konqui

Ahmed³

1985

Dermatology

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3 patients with multiple sclerosis (MS) who developed severe widespread bullous pemphigoid (BP) are presented. MS preceded the presentation of BP by 13–23 years (mean 18 years). BP was confirmed histologically and immunopathologically. Upon successful therapy with steroids, no recurrence of BP was observed over a 3–5 year (mean 3.7 years) follow-up. Several abnormalities of the immune system have been reported in both diseases. It is interesting to speculate that amidst existing immunologic abnormalities in all 3 patients with MS, a specific event, immunologic or viral or both may have triggered the development of BP.

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“…One might speculate that selection of IgGi antibody-producing cell clones is a normal feature occurring in any state of hyperimniunization to measles. Information on this question might be obtained by studying measles antibodies in other conditions, such as lupus erythematosus disseminatus, where measles antibody tevels frequently are increased (6). Alter-I atively, one might speculate that patients with "^SPE and MS inherently lack the capacity to respond to measles infection with antibodies • >i " subclasses otiier than IgGl.…”

Section: ')7mentioning

confidence: 99%

IgG1 Subclass Restriction of Oligoclonal Measles Virus‐Specific IgG Antibodies in Patients with Subacute Sclerosing Panencephalitis and in a Patient with Multiple Sclerosis

1977

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A restriction to the IgG1 subclass was demonstrated for measles virus-specific IgG antibodies isolated from the sera of five patients with subacute sclerosing panencephalitis, from the cerebrospinal fluid of one of the patients, and from brain extract from a sixth patient. A predominance of IgG1 was also observed in measles antibodies isolated from the serum and brain extract of a patient with multiple sclerosis. Evidence is presented that the IgG1 restriction is associated with the occurrence of oligoclonal measles antibodies in these patients. A similar restriction to the IgG1 subclass was not observed in measles antibodies isolated from the serum of a measles-convalescent child or from pooled normal serum and IgG.

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The Influence of Serum Immunoglobulin Concentration on Measles Antibody Level

Cited by 15 publications

References 8 publications

Oligoclonal Measles Virus‐Specific IgG Antibodies Isolated from Cerebrospinal Fluids, Brain Extracts, and Sera from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

Oligoclonal Measles Virus‐Specific IgG Antibodies Isolated from Cerebrospinal Fluids, Brain Extracts, and Sera from Patients with Subacute Sclerosing Panencephalitis and Multiple Sclerosis

Multiple Sclerosis and Bullous Pemphigoid

IgG1 Subclass Restriction of Oligoclonal Measles Virus‐Specific IgG Antibodies in Patients with Subacute Sclerosing Panencephalitis and in a Patient with Multiple Sclerosis

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