The Influence of Sex, Age, Blood Pressure and Physical Stress on ??2-Adrenoceptor Density of Mononuclear Cells

Middeke, Martin; Remien, J.; Holzgreve, Heinrich

doi:10.1097/00004872-198406000-00007

Cited by 25 publications

(12 citation statements)

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“…No patient had received adrenergic agonists or antagonists for at least 3 weeks. All medications were withdrawn for [12][13][14][15][16][17][18][19][20][21][22][23][24] hours before study.…”

Section: Subjectsmentioning

confidence: 99%

Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure.

et al. 1990

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Dynamic exercise increases the number of j-adrenergic receptors in mixed lymphocytes by a mechanism that is incompletely understood. In a set of in vivo studies, we have investigated the effects of dynamic exercise on the subset distribution of circulating lymphocytes and on the number of fJ-adrenergic receptors in each of these subsets in two groups of patients. In healthy subjects, exercise increased plasma norepinephrine and epinephrine and caused lymphocytosis. Whereas the number of The,lper cells increased only modestly, the number of Tsuppressoricytotoxic and natural killer cells more than tripled. The number of f-adrenergic receptors varied among subsets but was not significantly altered by dynamic exercise in any subset except natural killer cells (35% increase, p=0.0302). In a group of patients with congestive heart failure, dynamic exercise increased plasma norepinephrine but did not alter plasma epinephrine and did not cause significant lymphocytosis. We did not detect any significant alterations of circulating leukocyte subsets or /3-adrenergic receptors in any of these subsets after exercise. A combined analysis of healthy patients and heart failure patients revealed a significant correlation between increases in plasma epinephrine and increases in circulating lymphocytes. We conclude that the exercise-induced increase in /8-adrenergic receptors of mixed lymphocytes is predominantly caused by a redistribution of circulating cell subsets that differ in their 3-adrenergic receptor number. This appears to be mediated by epinephrine rather than norepinephrine. (Circulation 1990;82:2003-2010 It is well documented that prolonged exposure to agonists decreases the number of /3-adrenergic receptors in cultured cells and solid tissues of animals and humans in vitro and in ViVO.1-3 Such downregulation also occurs in human lymphocytes after prolonged treatment with 13-adrenergic agonists.

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Section: Subjectsmentioning

confidence: 99%

Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure.

et al. 1990

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“…2,3,8,9 Possible causes may be 1) smaller heart and blood volume 2,3,8 ; 2) greater stimulation of peripheral chemoreceptors 8 ; 3) lower levels of circulating catecholamines 10 ; 4) lower responsiveness of beta-adrenergic receptors 11 and 5) difference in the adjustment of thermoregulation mechanisms 12,13 .…”

Section: Cardiovascular Aspectsmentioning

confidence: 99%

“…2). Possible mechanisms suggested for this attenuated systolic activity in children are 1) smaller cardiac and blood volumes 2,3,8 ; 2) lower levels of circulating catecholamines 11,21 . According to the authors, there are no indications that myocardial contractility is smaller in children and tends to increase with physical maturity.…”

Section: Stroke Volumementioning

confidence: 99%

Comportamento das variáveis cardiovasculares, ventilatórias e metabólicas durante o exercício: diferenças entre crianças e adultos

Prado

Dias²,

Trombetta³

2006

Arq. Bras. Cardiol.

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“…Es lag nahe anZunehmen, dab eine erh6hte Anzahl von Adrenozeptoren ffir diese gesteigerte Gef'~iBreagibilit~it verantwortlich sei. Tats/ichlich konnte bei Patienten und Patientinnen mit essentieller Hypertonie eine h6here Anzahl von fl-Adrenozeptoren an peripheren Lymphozyten nachgewiesen werden [6][7][8]. Dagegen sind die Befunde beziiglich der Anzahl thrombozyt~irer alphaAdrenozeptoren bei der essentiellen Hypertonie widersprfichlich [9,10].…”

Section: Adrenozeptorenunclassified

Adrenozeptoren und Schwangerschaftshypertonie

Middeke¹

1989

Arch Gynecol Obstet

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During the last 10 years, radioligand binding studies have greatly advanced our knowledge about adrenoceptors in circulating lymphocytes. In essential hypertension the activity of the sympathetic system seems to be altered. Stimulation of the sympathetic system leads to rapid increase of lymphocyte beta-2-adrenoceptor density. In contrast, gestational hypertension is characterized by a decrease in cardiac output and enhanced arteriolar and venolar resistance. Peripheral resistance is modulated by alpha- and beta adrenoceptors and further studies are needed to characterize and quantify adrenoceptor density in gestational hypertension.

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The Influence of Sex, Age, Blood Pressure and Physical Stress on ??2-Adrenoceptor Density of Mononuclear Cells

Cited by 25 publications

References 0 publications

Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure.

Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure.

Comportamento das variáveis cardiovasculares, ventilatórias e metabólicas durante o exercício: diferenças entre crianças e adultos

Adrenozeptoren und Schwangerschaftshypertonie

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