The Influence of Shock on Cerebral Hemodynamics and Metabolism

Fazekas, Joseph F.; Kleh, Jack; Parrish, Alvin E.

doi:10.1097/00000441-195501000-00007

Cited by 25 publications

(4 citation statements)

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“…28 Despite this fall in the resistance, cerebral blood flow was reduced in all these studies. Our results, taken in conjunction with these others, suggest that the cerebral blood supply is indeed guarded in the hemorrhaged animal, but that the protection of cerebral blood flow is effective only when the hemorrhage is small to moderate.…”

Section: Myocardial Blood Flow Fraction Myocardial Blood Flow Myocamentioning

confidence: 84%

Effect of Hemorrhage on the Cardiac Output and Distribution in the Rat

Sapirstein

Bredemeyer

1960

Circulation Research

138

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MethodsThe animals used in these studies were females of the Sprague Dawley strain which had been fasted IS hours before use. Water was allowed during the fast. At the time of the experiment, the animals weighed 175 to 225 Gm. Sodium pentobarbital (40 mg./Kg. intraperitoneally) was used as the anesthetic.Two levels of hemorrhage were employed, 10 ml./Kg -. and 21 to 25 ml./Kg. The smaller hemorrhages were accomplished by withdrawal of blood from the femoral vein after the intravenous administration of 1 ing. heparin per rat. The larger hemorrhages were, in most cases, accomplished similarly. In some cases, the femoral artery and vein were cut together with a razor blade and the lost blood absorbed and weighed on cotton pledgets; bleeding usually stopped spontaneously after the loss of 21 to 25 nil. of blood/ Kg'. In a few cases, the hemorrhage was from a catheter in the carotid artery. The route of hemorrhage had no discernible effect on the results.

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Section: Myocardial Blood Flow Fraction Myocardial Blood Flow Myocamentioning

confidence: 84%

Effect of Hemorrhage on the Cardiac Output and Distribution in the Rat

Sapirstein

Bredemeyer

1960

Circulation Research

138

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“…Further, while large falls in blood pressure are frequently produced by treatment in hypertensive patients, many of whom also suffer from occlusive cerebral vascular disease, it is unusual for a focal ischaemic attack to occur (Fazekas, Kleh, and Parrish, 1955). If transient attacks are due to temporary falls of pressure in the carotid territory, and if the dynamometer reflects the pressure changes in the upper part of the artery, it would be expected that patients with a recent carotid occlusion who show a marked fall in ophthalmic pressure would suffer frequently from transient attacks.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmodynamometry in Carotid Artery Disease

Russell¹,

Cranston²

1961

Journal of Neurology, Neurosurgery & Psychiatry

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“…The goals during this period are cardiopulmonary/cerebral resuscitation [25]. This encompasses establishment of an adequate airway and, if necessary, mechanical ventilation, restoration of productive cardiac rhythm and forward blood flow, and attainment of a mean arterial blood pressure above 60 mmHg [26]. Without achieving the latter initial goal, all other resuscitative goals are of questionable value and thus should not be considered alone.…”

Section: Impact Of Pac On Patients Outcomementioning

confidence: 99%

Untitled

2006

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The pulmonary artery catheter (PAC) was introduced in 1971 for the assessment of heart function at the bedside. Since then it has generated much enthusiasm and controversy regarding the benefits and potential harms caused by this invasive form of hemodynamic monitoring. This review discusses all clinical studies conducted during the past 30 years, in intensive care unit settings or post mortem, on the impact of the PAC on outcomes and complications resulting from the procedure. Although most of the historical observational studies and randomized clinical trials also looked at PAC-related complications among their end-points, we opted to review the data under two main topics: the impact of PAC on clinical outcomes and cost-effectiveness, and the major complications related to the use of the PAC.

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The Influence of Shock on Cerebral Hemodynamics and Metabolism

Cited by 25 publications

References 0 publications

Effect of Hemorrhage on the Cardiac Output and Distribution in the Rat

Effect of Hemorrhage on the Cardiac Output and Distribution in the Rat

Ophthalmodynamometry in Carotid Artery Disease

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