Southwest China’s arid river valleys represent ecologically vulnerable areas with intense human activity. Understanding the historical changes in LULC and land cover and projecting the impacts of various development scenarios on future LULC have become crucial for regional spatial information management and territorial spatial planning. This research analyzes the land-use changes in the Yuanmou dry-hot valley over a 30-year span from 1990 to 2020. Building upon the PLUS model, we established a coupled habitat quality spatial and multi-scenario land-use simulation model. Four development scenarios were proposed: natural progression, economic development, ecological conservation, and balanced development. We conducted simulations and evaluations of land-use in the Yuanmou dry-hot valley for 2030 using the PLUS mode, assessing the sustainability of future development scenarios under varying ecological constraints. During the simulation, three distinct RESI regions were employed as restricted development zones, integrating the three ecological constraints with the four simulation scenarios. We introduced a novel approach based on ecological environmental quality as the ecological constraint, providing a scientific reference for sustainable development in ecologically vulnerable areas. The results indicate that under ecological conservation scenarios with high-to-low RESI constraints, the ecological environment is superior to the other three scenarios. The results show the following: (1) From 1990 to 2020, aside from a continuous decrease in grassland area, there was an increasing trend in the areas of water bodies, forests, croplands, construction lands, and unused lands in the Yuanmou dry-hot valley. (2) By 2030, under all four development scenarios, the cropland area is expected to expand rapidly, while forested areas will decrease; grassland areas will decline under natural and economic development scenarios but show opposite trends under the other scenarios; and construction land and unused land areas will decrease under the ecological conservation and balanced development scenarios. (3) Land-use intensity analysis for the four scenarios indicated that, by 2030, unused lands in the Yuanmou dry-hot valley are more likely to be converted into water bodies, forests are more likely to be converted into croplands and grasslands, grasslands are more likely to be converted into croplands, croplands are more likely to be converted into grasslands, and construction lands are more likely to become unused lands. (4) Sustainable LULC management evaluations based on landscape indices reveal that ecological conservation and balanced development scenarios exhibit superior landscape connectivity and clustering. Thus, the balanced development scenario is the most appropriate LULC strategy for the Yuanmou dry-hot valley in the future. These findings provide scientific references for balancing ecological conservation and economic development in the arid river valleys of Southwest China.