The Influence of Silicone Oil on the Ganglion Cell Complex After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment

Raczyńska, Dorota; Mitrosz, Kamila; Raczyńska, Krystyna; Glasner, Leopold

doi:10.2174/1381612824666180813115438

Cited by 30 publications

(28 citation statements)

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“…NFL thickness decrease echoed the experimental results of inner retina thickness change and loss of neuronal connections after surgical repair of RRD [29]. Furthermore, previous study has also described the potential toxic effect of SO on ganglion cells [14]. Thus, according to the more significant decrease of NFL thickness in SO tamponade eyes, we may demonstrate that SO tamponade could have more negative impact on ganglion cells compared to Gas tamponade.…”

Section: Retinal Layer Thickness Changesupporting

confidence: 73%

“…The application of OCT in RRD patients allowed the detection of microscopic fundus structural abnormalities after retinal repair [13][14][15]. Negative tamponade effects of SO has been described such as thickness change in specific retinal layers and choroidal thinning [14][15][16]. However, few studies focused on the investigation of different fundus changes owing to different intravitreal tamponade materials, or included follow-up observations.…”

Section: Introductionmentioning

confidence: 99%

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Different tamponade effects of intraocular silicone oil and sterilized air after single pars plana vitrectomy for rhegmatogenous retinal detachment

Zhou¹,

Zhang²,

Gao³

et al. 2020

Preprint

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Purpose: To investigate different fundus vasculature and structure changes after single pars plana vitrectomy (PPV) following silicone oil (SO) or sterilized air in macular-off rhegmatogenous retinal detachment (RRD) patients. Method: 39 eyes (39 patients) with macular-off RRD underwent standard three-port 23-gauge PPV and intraocular SO or gas tamponade. Optical Coherence Tomography (OCT) and angiography were used to evaluate fundus structure and vasculature including retinal layers thicknesses and vessel density (VD) changes throughout observation for 12 weeks. Retinal layers were segmented into: NFL, GCL+IPL, INL, OPL, ONL+IS, OS+RPE and BRM. Fundus vasculature was segmented into superficial and deep capillary plexus (SCP, DCP), and choriocapillaris plexus (CCP). Result: For fundus vasculature, SO tamponade led to significant decrease in both SCPVD and DCPVD, while only SCPVD was found significantly decreased in gas tamponade eyes. For specific retinal layer, SO led to significant decrease in NFL and INL thicknesses. OPL, ONL+IS and OS+RPE thicknesses had significant increase in both SO tamponade and gas tamponade eyes. Conclusion: Different intraocular tamponades could have various impacts on retinal vasculature and structure. Compared to sterilized air, silicone oil tamponade could have relatively more negative effects on retinal vasculature and specific retinal layer thickness change.

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Section: Retinal Layer Thickness Changesupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Different tamponade effects of intraocular silicone oil and sterilized air after single pars plana vitrectomy for rhegmatogenous retinal detachment

Zhou¹,

Zhang²,

Gao³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Although the time of removal of the silicone oil could vary according to the indication for implantation, it is recommended to do it as soon as possible, as silicone oil may have a toxic effect on the retina. [33][34][35][36] In our study, we removed the silicone oil endotamponade from all eyes 3 months later. There have been reported rare cases of IVD-related acute retinal necrosis, 37 epiretinal proliferation around the IVD, 38 and implant trapped at the macula 39 in vitrectomized eyes with silicone oil.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Coadministration of Intravitreal Dexamethasone Implant and Silicone Oil Endotamponade for Proliferative Diabetic Retinopathy with Tractional Diabetic Macular Edema

Altun

Kanar

Aki

et al. 2021

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To investigate the efficacy and safety of coadministered intravitreal dexamethasone (IVD) implant and silicone oil endotamponade during pars plana vitrectomy (PPV) for the treatment of proliferative diabetic retinopathy (PDR) with tractional diabetic macular edema (DME). Methods: In this prospective, controlled, and randomized clinical study, the eyes with PDR and vitreomacular traction syndrome that underwent PPV with silicone oil endotamponade were divided into 2 groups. Group 1 was defined as the control group, and no other procedures were performed. IVD was implanted to the eyes in Group 2. In both groups, panretinal photocoagulation was completed to the missed areas during PPV. All cases followed for 6 months, postoperatively. Retinal findings were followed with optical coherence tomography and fluorescein fundus angiography. Results: A total of 52 eyes of 52 patients were included in the study. Twenty-six eyes of 23 patients were included in both groups. The improvement in best corrected visual acuity was statistically significantly higher in Group 2 (P > 0.05). In the postoperative period, the DME development rate and intravitreal ranibizumab (IVR) injection requirement were significantly higher in Group 1 (P > 0.05). There was no statistically significant difference in the proliferative vitroretinopathy development rate between the groups (P < 0.05). Conclusion: Coadministration of IVD implant and silicone oil endotamponade to the eyes with PDR during vitrectomy seems to be safe and effective application and may decrease the rate of DME and the requirement of IVR injection.

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“…[9] Some studies have shown that silicone oil due to the concentration of low molecular weight components and amphiphilic substances has toxic effects on the anterior segment, trabecular meshwork, ganglion cell complex, and retinal pigment epithelium. [17,18] Veckeneer et al reported that the residue caused relative scotomata in four patients. In two of those patients, the symptoms were temporary because the sticky silicone oil bubbles spontaneously detached and migrated upwards to the 12 o'clock position.…”

Section: Discussionmentioning

confidence: 99%

Removal of Sticky Silicone Oil Adhered to the Retinal Surface: Comparison of Methodological Safety and Effectiveness

Wang

Zhang

et al. 2021

Preprint

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Purpose: To compare safety and effectiveness among methods to remove sticky silicone oil bubbles adhered to the retinal surface. Methods: This retrospective nonrandomised case series included 14 eyes of 14 patients who had sticky silicone oil residue during silicone oil removal surgery. For small sticky silicone oil bubbles (<2-disc diameter), aspiration was performed with a 23-gauge vitreous cutter. Residual tiny oil bubbles were then removed with a silicone-tipped flute needle or internal limiting membrane (ILM) peeling. For large sticky silicone oil bubbles (≥2-disc diameter) that could not be removed with a 23-gauge vitreous cutter, we devised a more efficient active removal method involving a modified 22-gauge venous indwelling cannula device. Results: The mean preoperative best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution [logMAR]) significantly improved from 1.28±0.63 logMAR to 0.77±0.58 logMAR (p=0.014). The postoperative BCVA and improvement in BCVA were significantly better in the ILM peeling group than in the non-ILM peeling group (p=0.004 and p=0.045, respectively). Postoperative complications included residual sticky silicone oil bubbles in seven eyes without ILM peeling (50.0%), retinal neuroepithelial layer damage in two eyes (14.3%), and temporary hypotony in five eyes (35.7%). Conclusion: Various methods can safely and efficiently remove sticky silicone oil bubbles adhered to the retinal surface. A 22-gauge venous indwelling cannula enabled simple and safe removal of large sticky silicone oil bubbles, while small residual sticky silicone oil bubbles could be completely removed by ILM peeling.

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The Influence of Silicone Oil on the Ganglion Cell Complex After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment

Cited by 30 publications

References 0 publications

Different tamponade effects of intraocular silicone oil and sterilized air after single pars plana vitrectomy for rhegmatogenous retinal detachment

Different tamponade effects of intraocular silicone oil and sterilized air after single pars plana vitrectomy for rhegmatogenous retinal detachment

Effectiveness and Safety of Coadministration of Intravitreal Dexamethasone Implant and Silicone Oil Endotamponade for Proliferative Diabetic Retinopathy with Tractional Diabetic Macular Edema

Removal of Sticky Silicone Oil Adhered to the Retinal Surface: Comparison of Methodological Safety and Effectiveness

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