The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model

Shimomura, Kazunori; Ando, Wataru; Tateishi, Kosuke; Nansai, Ryosuke; Fujie, Hiromichi; Hart, David A.; Kohda, Hideyuki; Kita, Keisuke; Kanamoto, Takashi; Mae, Tatsuo; Nakata, Ken; Shino, Konsei; Yoshikawa, Hideki; Nakamura, Norimasa

doi:10.1016/j.biomaterials.2010.07.017

Cited by 130 publications

(124 citation statements)

References 45 publications

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“…The AC presents a notable matrix structure organization [6], a limited number of chondrocytes [7], and a rich water content [8]. The most important biomechanical functions of the AC include weight bearing and a smooth distribution of forces to the adjacent subchondral bone, providing nonfrictional motion of joints [4,8].…”

Section: Osteoarticular Disorders and Regeneration Physiologymentioning

confidence: 99%

“…MSCs were first harvested from the bone marrow by Friedenstein in 1976 [29,31,32], but now their presence is well established in virtually all postnatal tissues [5,[31][32][33][34], being involved in the tissue growth and homeostasis [31]. They have since been isolated from different adult tissues [30-32, 35, 36], such as fat, bone marrow, bone, cartilage [6], periosteum [32], nervous tissues, tendon, ligament, epithelium, SM, lung, peripheral blood, skeletal muscle, and nonadult tissues, such as amniotic fluid, placenta, and umbilical cord blood and stroma [29].…”

Section: Msc Sources Applicable For Musculoskeletal Regenerationmentioning

confidence: 99%

“…They are characterized by an extensive proliferation ability in culture and have the potential to differentiate in vitro into different lineages [5,32,33,36], including adipogenic, chondrogenic, osteogenic [6,29,31,35], myogenic [6,31,35,37], and neurogenic [6,37].…”

Section: Msc Sources Applicable For Musculoskeletal Regenerationmentioning

confidence: 99%

“…SM-MSCs have been successfully differentiated into osteogenesis, chondrogenesis, and adipogenesis [31,35], as well as toward myogenesis, but at a minor extent. They maintain their intrinsic differentiation characteristics, regardless of the donor, age [4,6,31], cell passage number, or cryopreservation [31]. SM-MSCs can produce hyaline-like cartilage tissue, under specific conditions, becoming a promising approach to cartilage injury therapies [4].…”

Section: Characterization Of Synovia-derived Mscsmentioning

confidence: 99%

“…Shimomura et al used a TEC based on SM-MSCs derived from immature and mature pigs, in order to address the age dependency in chondrogenic and proliferation abilities of SM-MSCs. No differences were reported between the groups, suggesting no age dependency [6]. Ando et al similarly used a porcine allograft model, with a basic TEC composed of collagen I, III, vitronectin, and fibronectin.…”

Section: Sm-mscs' Therapeutic Applicationsmentioning

confidence: 99%

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Synovia-Derived Mesenchymal Stem Cell Application in Musculoskeletal Injuries: A Review

Branquinho¹,

Caseiro²,

SantosPedrosa³

et al. 2018

Tissue Regeneration

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Musculoskeletal injuries impact millions of people globally and affect their health and well-being as well as of their companion and athletic animals. Soft-tissue injuries represent almost half of these and are associated with unorganized scar tissue formation and long time-depending healing processes. Cell-based therapeutic strategies have been developed in the past decades aiming at the treatment and reversion of such disorders. Stem cells are fairly appealing in the field, being a responsive undifferentiated population, with ability to self-renew and differentiate into different lineages. Mesenchymal stem cells (MSCs) can be obtained from several adult tissues, including the synovial membrane. Synovia-derived MSCs can be found in individuals of any age and are associated to intrinsic regenerative processes, through both paracrine and cell-to-cell interactions, thus, contributing to hosts' healing capacity. Studies have demonstrated the potential benefit of synovia-derived MSCs in these regenerative processes in both human and veterinary medicine. The purpose of this chapter is to review the literature regarding SM-MSC therapies applied to musculoskeletal disorders, in both human and veterinary medicine.

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Section: Osteoarticular Disorders and Regeneration Physiologymentioning

confidence: 99%

Section: Msc Sources Applicable For Musculoskeletal Regenerationmentioning

confidence: 99%

Section: Msc Sources Applicable For Musculoskeletal Regenerationmentioning

confidence: 99%

Section: Characterization Of Synovia-derived Mscsmentioning

confidence: 99%

Section: Sm-mscs' Therapeutic Applicationsmentioning

confidence: 99%

See 3 more Smart Citations

Synovia-Derived Mesenchymal Stem Cell Application in Musculoskeletal Injuries: A Review

Branquinho¹,

Caseiro²,

SantosPedrosa³

et al. 2018

Tissue Regeneration

View full text Add to dashboard Cite

show abstract

Systematic Comparison of Biomaterials‐Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

González-Vázquez

Ferreras

Bennett

et al. 2021

Adv Healthcare Materials

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Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial design has led to the fabrication of a plethora of promising devices. Pre-clinical testing of any joint repair strategy typically requires the use of large animal models (e.g., sheep, goat, pig or horse). Despite the key role of such models in clinical translation, there is still a lack of consensus regarding optimal experimental design, making it difficult to draw conclusions on their efficacy. In this context, the authors performed a systematic literature review and a risk of bias assessment on large animal models published between 2010 and 2020, to identify key experimental parameters that significantly affect the biomaterial therapeutic outcome and clinical translation potential (including defect localization, animal age/maturity, selection of controls, cell-free versus cell-laden). They determined that mechanically strong biomaterials perform better at the femoral condyles; while highlighted the importance of including native tissue controls to better evaluate the quality of the newly formed tissue. Finally, in cell-laded biomaterials, the pre-culture conditions played a more important role in defect repair than the cell type. In summary, here they present a systematic evaluation on how the experimental design of preclinical models influences biomaterial-based therapeutic outcomes in joint repair.

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Selective Extracellular Matrix Guided Mesenchymal Stem Cell Self‐Aggregate Engineering for Replication of Meniscal Zonal Tissue Gradient in a Porcine Meniscectomy Model

Noh

Jin

Shin

et al. 2023

Adv Healthcare Materials

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Degenerative meniscus tears (DMTs) are prevalent findings in osteoarthritic knees, yet current treatment is mostly limited to arthroscopic partial meniscectomy rather than regeneration, which further exacerbates arthritic changes. Translational research regarding meniscus regeneration is hindered by the complex, composite nature of the meniscus which exhibit a gradient from inner cartilage‐like tissue to outer fibrous tissue, as well as engineering hurdles often requiring growth factors and cross‐linking agents. Here, a meniscus zonal tissue gradient is proposed using zone‐specific decellularized meniscus extracellular matrix (DMECM) and autologous synovial mesenchymal stem cells (SMSC) via self‐aggregation without the use of growth factors or cross‐linking agents. Combination with zone‐specific DMECM during self‐aggregation of MSCs forms zone‐specific meniscus tissue that reflects the respective DMECM harvest site. The implantation of these constructs leads to the regeneration of meniscus tissue resembling the native meniscus, demonstrating inner cartilaginous and outer fibrous characteristics as well as recovery of native meniscal microarchitecture in a porcine partial meniscectomy model at 6 months. In all, the findings offer a potential regenerative therapy for DMTs that may improve current partial meniscectomy‐based patient care.

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The influence of skeletal maturity on allogenic synovial mesenchymal stem cell-based repair of cartilage in a large animal model

Cited by 130 publications

References 45 publications

Synovia-Derived Mesenchymal Stem Cell Application in Musculoskeletal Injuries: A Review

Synovia-Derived Mesenchymal Stem Cell Application in Musculoskeletal Injuries: A Review

Systematic Comparison of Biomaterials‐Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Selective Extracellular Matrix Guided Mesenchymal Stem Cell Self‐Aggregate Engineering for Replication of Meniscal Zonal Tissue Gradient in a Porcine Meniscectomy Model

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