The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men

Kumosani, Taha; Elshal, Mohamed F.; Al-Jonaid, A.A.; AbdulJabar, Hassan S.O.

doi:10.1016/j.clinbiochem.2008.07.013

Cited by 62 publications

(40 citation statements)

References 50 publications

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“…The mechanism behind the harmful effect of smoking on semen quality is not fully understood. Disturbance of the hypothalamo-pituitary-gonadal system (35) or mild hypoxia caused by the disruption of the testicular microcirculation (36) are possible explanations, but a direct toxic effect of the many chemical components in cigarette smoking on the germinative epithelium is a more likely (37,38). Oxidants in cigarette smoke are thought to damage sperm DNA, and smokers have more oxidative DNA damage in their sperm than do non-smokers (39).…”

Section: Discussionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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Objectives: (i) To examine the role of apoptosis in the pathogenesis of DNA damage in semen from infertile men. (ii) To assess the effects of smoking on apoptotic markers and seminal parameters among infertile men. (iii) To assess the correlation of apoptosis with conventional semen parameters. Materials and Methods:The study was carried out on 70 men with idiopathic infertility, divided into two groups: thirty infertile non smokers and forty infertile smokers. In addition to 60 fertile men (30 non smokers and 30 smokers) as control group. Each subject provided semen for analysis of parameters, determination of % of DNA fragmentation, s-Fas, caspase-3 activity levels and cotinine levels. Results:The results revealed that infertile men, particularly smokers have significantly lower semen variables and significantly higher levels of apoptotic variables (% of DNA fragmentation, s-Fas and caspase-3 activity) in addition to cotinine. Conclusions:The present findings provide additional evidence supporting the importance of the evaluation of apoptotic markers to test male infertility particularly among smokers.

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Section: Discussionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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“…Sperm parameters can provide valuable information regarding potential reproductive toxicity (Seed et al 1996). In human smokers, there are reports that cigarette smoking can reduce sperm concentration (Künzle et al 2003;Liu et al 2010), percentage of motile (Sofikitis et al 1995;Kumosani et al 2008;Liu et al 2010) and normal sperm morphology (Sofikitis et al 1995;Künzle et al 2003;Liu et al 2010). In the rats, Yamamoto et al (1998) and Kapawa et al (2004) observed that long-term exposure to cigarette smoke provoked reductions in sperm concentration and/or motility.…”

Section: Discussionmentioning

confidence: 99%

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Sankako

Garcia

Piffer

et al. 2013

Braz. arch. biol. technol.

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“…Ex vivo studies have shown that fully mature sperm are not susceptible to CO (Makler et al, 1993), indicating that CO may affect the acquisition of sperm motility in the epididymis. Additional toxicants that are present at higher levels in SS smoke than MS smoke and that have been implicated with reduced sperm motility include reactive oxygen species (Kao et al, 2008;Tremellen, 2008) and cadmium (Xu et al, 2001;Kumosani et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse

Polyzos

Schmid

Piña-Guzmán

et al. 2009

Toxicology and Applied Pharmacology

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Cigarette smoking in men has been associated with increased chromosomal abnormalities in sperm and with increased risks for spontaneous abortions, birth defects and neonatal death.Little is known, however, about the reproductive consequences of paternal exposure to secondhand smoke. We used a mouse model to investigate the effects of paternal exposure to sidestream (SS) smoke, the main constituent of second-hand smoke, on the genetic integrity and function of sperm, and to determine whether male germ cells were equally sensitive to mainstream (MS) and SS smoke. A series of sperm DNA quality and reproductive endpoints were investigated after exposing male mice for two weeks to MS or SS smoke. Our results indicated that: (i) only SS smoke significantly affected sperm motility; (ii) only MS smoke induced DNA strand breaks in sperm; (iii) both MS and SS smoke increased sperm chromatin structure abnormalities; and (iv) MS smoke affected both fertilization and the rate of early embryonic development, while SS smoke affected fertilization only. These results show that MS and SS smoke have differential effects on the genetic integrity and function of sperm and provide further evidence that male exposure to second-hand smoke, as well as direct cigarette smoke, may diminish a couple's chance for a successful pregnancy and the birth of a healthy baby.

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The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men

Cited by 62 publications

References 50 publications

Apoptotic markers in semen of infertile men: association with cigarette smoking

Apoptotic markers in semen of infertile men: association with cigarette smoking

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse

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