The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit

Bonaccorsi, A.; Domenico, Alessandro Di; Fanelli, Robert D.; Merli, F.; Motta, Rogério Heládio Lopes; Vanzati, R.; Zapponi, G.

doi:10.1007/978-3-642-69132-4_82

Cited by 30 publications

(16 citation statements)

References 5 publications

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“…The results presented here are consistent with those from other in vitro or in vivo studies that indicate that matrix effects can substantially reduce the absorption of PCDD/Fs from soil (Budinsky et al 2008;Bonaccorsi et al 1984;Umbreit et al1988;Ruby et al 2002;Poiger and Schlatter 1980;Shu et al 1988). The results are also consistent with previous in vivo studies that indicate that the tetra-and penta-chlorinated PCCD/Fs are relatively well absorbed following oral administration, while the bioavailability of more highly chlorinated PCDD/Fs is substantially lower (Birnbaum and Couture 1988;Brewster and Birnbaum 1987;Van den Berg et al 1985;Stephens et al 1995;Diliberto et al 1996).…”

Section: Discussionsupporting

confidence: 95%

“…As the influence of the matrix effect increases, the relative oral bioavailability value (usually reported as a percentage) decreases. The relative oral bioavailability of TCDD in site-specific soils has been evaluated in several published studies, and the values typically range from 10-40% (Bonaccorsi et al 1984;Lucier et al 1986;McConnell et al 1984;Shu et al 1988;Umbreit et al 1986;Umbreit et al 1988;Wendling et al 1989;Wittsieppe et al 2001;Ruby et al, 2002;Wittsieppe et al 2007). While TCDD has been evaluated fairly extensively, very few oral bioavailability studies have examined the sixteen other 2,3,7,8-substituted PCDD/F congeners that often must be considered in health risk assessments.…”

Section: Bioavailability Of Dibenzo-p-dioxins/dibenzofuransmentioning

confidence: 97%

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Oral Bioavailability of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Industrial Soils

Finley¹,

Fehling²,

Warmerdam³

et al. 2009

Human and Ecological Risk Assessment: An International Journal

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In this study, the oral bioavailabilities of numerous 2,3,7,8-PCDD/F congeners were evaluated in soil samples from an industrial site. The purpose of this study is several-fold: (1) to compare the soil bioavailability results of the different PCDD/F congeners; (2) to evaluate the consistency of the bioavailability results with those obtained in an in vitro bioaccessibility study with simulated GI tract fluids; and (3) to develop quantitative bioavailability measurements that are appropriate for use in a health risk assessment for this site. Soil samples containing PCDD/F toxic equivalent (TEQ) concentrations ranging from 0.53-45.2 ng/g were administered to female Sprague Dawley rats via oral gavage. Reference formulations of PCDD/Fs were administered intravenously or by oral gavage. The overall relative bioavailability of PCDD/Fs in the soil samples on a TEQ basis ranged from 17 to 51%, with a mean of 38%. The results of the in vitro bioaccessibility study were consistent with the bioavailability results (mean extracted TEQ of 22%). Because of the clear relationship between increasing chlorination and decreasing bioavailability and bioaccessibility observed in this study, we suggest that simply extrapolating results from one congener to another may be associated with a high degree of uncertainty.

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Section: Discussionsupporting

confidence: 95%

Section: Bioavailability Of Dibenzo-p-dioxins/dibenzofuransmentioning

confidence: 97%

Oral Bioavailability of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Industrial Soils

Finley¹,

Fehling²,

Warmerdam³

et al. 2009

Human and Ecological Risk Assessment: An International Journal

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“…In conclusion, the results implicate that soil-borne PAHs, if immobilized onto soil organic matter, are nonbiodegradable and not to be released by rinsing soils • with water, Similar results have already been reported concerning the influence of soil sorption and biotoxicity of dioxins. The degree of dermal uptake of soil-borne 2,3,7,8-terachlorodibenzo-p-dioxin (TCCD) was highly reduced, compared with that of free (solvent-borne) T C C D in rabbit (Bonaccorsi et al 1984) and rat (Shu et al 1988). Furthermore, sorption onto activated carbon almost completely prevents dermal uptake of T C C D by rats (Poiger and Schlatter 1980).…”

Section: Discussionmentioning

confidence: 99%

Adsorption of polycyclic aromatic hydrocarbons (PAHs) by soil particles: influence on biodegradability and biotoxicity

Weissenfels¹,

Klewer²,

Langhoff³

1992

Appl Microbiol Biotechnol

391

174

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Polycyclic aromatic hydrocarbon (PAH) biodegradation was investigated in contaminated soils from two different industrial sites under simulated land treatment conditions. Soil samples from a former impregnation plant (soil A) showed high degradation rates of PAHs by the autochthonous microorganisms, whereas PAHs in material of a closed-down coking plant (soil B) were not degraded even after inoculation with bacteria known to effectively degrade PAHs. As rapid PAH biodegradation in soil B was observed after PAHs were extracted and restored into the extracted soil material, the kind of PAH binding in soil B appears to completely prevent biodegradation. Sorption of PAHs onto extracted material of soil B follows a two-phase process (fast and slow); the latter is discussed in terms of migration of PAHs into soil organic matter, representing less accessible sites within the soil matrix. Such sorbed PAHs are suggested to be non-bioavailable and thus non-biodegradable. By eluting soil B with water, no biotoxicity, assayed as inhibition of bioluminescence, was detected in the aqueous phase. When treating soil A analogously, a distinct toxicity was observed, which was reduced relative to the amount of activated carbon added to the soil material. The data suggest that sorption of organic pollutants onto soil organic matter significantly affects biodegradability as well as biotoxicity.

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“…Similar studies have also been performed in rabbits by Bonaccorsi et al (1984). Levels of TCDD in the liver 7 days after an oral dose of TCDD, either in alcohol or in soil from Seveso, Italy were compared.…”

Section: Studies On Soil Bioavailability Of Other Chemicalsmentioning

confidence: 95%

Absorption adjustment factor (AAF) distributions for polycyclic aromatic hydrocarbons (PAHS)

Magee¹,

Anderson²,

Burmaster

1996

Human and Ecological Risk Assessment: An International Journal

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The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit

Cited by 30 publications

References 5 publications

Oral Bioavailability of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Industrial Soils

Oral Bioavailability of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Industrial Soils

Adsorption of polycyclic aromatic hydrocarbons (PAHs) by soil particles: influence on biodegradability and biotoxicity

Absorption adjustment factor (AAF) distributions for polycyclic aromatic hydrocarbons (PAHS)

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