The influence of solar and geomagnetic activity on the risk of multiple sclerosis (results of correlation and regression analysis)

Samoylova, Nataliya A.; Shkilnyuk, G. G.; Гончарова, З. А.; Stolyarov, I. D.

doi:10.17116/jnevro20171172242-49

Cited by 2 publications

(1 citation statement)

References 45 publications

(38 reference statements)

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“…They also found that exposure to GMD during the first decade of life has a cumulative effect on the risk of obtaining MS in adulthood. A similar result has been observed recently by Samoylova et al in Russia [ 32 ].…”

Section: Supporting Evidencessupporting

confidence: 92%

Which Environmental Factor Is Correlated with Long-Term Multiple Sclerosis Incidence Trends: Ultraviolet B Radiation or Geomagnetic Disturbances?

Sajedi

Abdollahi

2017

Multiple Sclerosis International

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Background Insufficient received ultraviolet B radiation (UV) is regarded as the main environmental risk factor (RF) for MS in vitamin D deficiency hypothesis. Nevertheless, geomagnetic disturbance (GMD) has also been proposed as a potential trigger for MS in GMD hypothesis. The aim of this study was to investigate which of these mentioned RF is correlated with long-term ultradecadal MS incidence. Methods After a systematic search, long-term incidence reports of the United Kingdom (UK), Denmark, Tayside County, Nordland County, the Orkney, and Shetland Islands were selected for this retrospective time-series study. Possible lead-lag relationships between MS incidence, GMD, and UV were evaluated by cross-correlation analysis. Results Significant positive correlations between GMD and MS incidence were seen in Tayside County (at lag of 2 years: rS = 0.38), Denmark (peak correlation at lag of 2 years: rS = 0.53), and UK (at lag of 1 year: rS = 0.50). We found a positive correlation between received UV and MS incidences in the Nordland at lag of 1 year (rS = 0.49). Conclusion This study found significant positive correlations between alterations in GMD with alterations in long-term MS incidence in three out of six studied locations and supports the GMD hypothesis. The observed significant correlation between MS and UV is positive; hence it is not supportive for UV related vitamin D deficiency hypothesis.

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Section: Supporting Evidencessupporting

confidence: 92%

Which Environmental Factor Is Correlated with Long-Term Multiple Sclerosis Incidence Trends: Ultraviolet B Radiation or Geomagnetic Disturbances?

Sajedi

Abdollahi

2017

Multiple Sclerosis International

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Effects of solar activity and geographic latitude on genetic homeostasis of human somatic cells

Kalaev,

Zuevsky,

Nechaeva

et al. 2023

Ekologiya cheloveka (Human Ecology)

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AIM: is to determine the effect of solar activity on the genetic stability of human somatic cells as assessed by the micronucleus test in buccal epithelium, depending on the geographical location of the subjects. METHODS: The subjects were men aged 18 to 21 years, without bad habits, who have not taken any medication recently. Studies were conducted simultaneously in four cities of the Russian Federation (Voronezh, Sevastopol, Tomsk, Khanty-Mansiysk). The effect of three types of solar flares, whose classification is based on changes in the amplitude of the thermal X-ray burst, was studied. Material for cytogenetic study was collected on days 3, 7, and 10 after the solar flare. The human buccal epithelium micronucleus test was chosen as a method to evaluate genetic homeostasis. 495 thousand buccal epithelial cells were analyzed. Statistical processing of the study results was performed using "Stadia" and "Statistica" software packages. Identification of the influence of factors was performed using multivariate analysis of variance and two-factor analysis of variance with fixed effects. RESULTS: It was revealed that solar activity affects the stability of the human genetic apparatus by increasing the influence of the city pollution and its geographical location on the number of cells with nucleus abnormalities. The combined effect of solar flare and season of its occurrence on the number of cells with nucleus aberrations (the highest number of nuclear anomalies was registered in winter) was shown. No independent influence of solar activity on the number of cells with nuclear abnormalities was revealed. Thus, 3, 7, 10, and 17 days after the flare, no increase in the number of cells with nucleus anomalies was registered. CONCLUSION: The highest number of cells with nucleus abnormalities is observed in Sevastopol, which is associated with the highest anthropogenic pollution of this city compared to the other cities. Solar activity increases the influence of the city pollution and its geographical location on the number of cells with nucleus abnormalities. The results obtained can be used in conducting a micronucleus test of human buccal epithelium and in planning measures to assess the genotoxicity of the environment.

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The influence of solar and geomagnetic activity on the risk of multiple sclerosis (results of correlation and regression analysis)

Cited by 2 publications

References 45 publications

Which Environmental Factor Is Correlated with Long-Term Multiple Sclerosis Incidence Trends: Ultraviolet B Radiation or Geomagnetic Disturbances?

Which Environmental Factor Is Correlated with Long-Term Multiple Sclerosis Incidence Trends: Ultraviolet B Radiation or Geomagnetic Disturbances?

Effects of solar activity and geographic latitude on genetic homeostasis of human somatic cells

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