The Influence of Some β‐Adrenergic Stimulant Compounds on Intestinal Motility in Vitro and in Vivo in Mice

Abstract

The four β‐adrenergic stimulant agents terbutaline (TRB), orciprenaline (OPR), KWD 2026, and isoprenaline (IPR) were compared for their inhibiting effect on mice ileum in vitro as well as for their inhibiting effect on intestinal propulsion in intact animals. The activity was related to the chemical structure of the compounds. The slightest inhibition was produced by TRB, which has the hydroxy groups in the 3–5 position in the benzene ring and t‐butyl substituted at the nitrogen. The relaxing effect was blocked by alprenolol, indicating involvement of β‐adrenergic receptors.