Studying land use transition and restructuring has value for promoting sustainable regional development, especially in China’s vast rural areas, which are undergoing rapid changes. Current research tends to focus on the macro level, and analyses of driving forces are mostly based on the correlation analysis of influencing factors. However, in the case of villages and towns, which are at the micro level, it is important to know who promotes land use transition and how to promote it under the influence of the macro environment. This study, therefore, focused on the endogenous driving force behind land use transition and its characteristics at the micro level of villages and towns. On the basis of our theoretical framework, an empirical study was carried out on the transformation and restructuring of ecology–production–living (EPL) spaces in the town of Zhulin in Central China over the past 30 years. We found the following: (1) The overall distribution of EPL spaces in Zhulin shifted from mixed distribution to relatively concentrated distribution, and the spatial transfer of EPL spaces showed fluctuations in the expansion and contraction of different types of spaces. (2) Land use transition was more active in spatial interface areas than in noninterface areas, where the interconversion of ecological space and agricultural production space was concentrated at the terrain interface. In addition, transformation processes related to living space and non-agricultural production space were concentrated at the urban–rural interface. (3) Macro-level social and economic changes were the root cause of land use transformation, and the autonomous spatial governance capability of villagers’ self-organization institutions was key to regulating land use transformation. The spatial interface was a sensitive area for land use transformation in a natural state. An endogenous driving mode of active response to land use transformation based on rural autonomous spatial governance capability and spatial interface sensitivity is proposed. How to improve the rural governance capacity of key local actors in different regions and at different levels is an aspect worthy of further consideration.