The Influence of Strain, Sex and Age of Mice on Infection with Plasmodium Berghei

Greenberg, Joseph; Nadel, Eli M.; Coatney, G. Robert

doi:10.1093/infdis/93.1.96

Cited by 29 publications

(8 citation statements)

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“…resistant RI strains exhibited marked splenomegaly similar to the resistant B6 progenitor. DISCUSSION Genetic control of host resistance to malaria has been demonstrated in several murine models, including a model of resistance to P. chabaudi described by our laboratory (10,15,18,25). In that report, we concluded that the difference at a single genetic locus was the most likely explanation for the ratios of resistant to susceptible (as defined by survival) progeny obtained in hybrid, backcross, and F2 generations derived from the strain combination of extremely susceptible A mice and resistant C57BL-derived B10.A mice.…”

Section: Resultsmentioning

confidence: 91%

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Stevenson¹,

Skamene²

1985

Infect Immun

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The level of resistance to infection with Plasmodium chabaudi is genetically controlled. We have previously reported that a single dominant gene is responsible for the variation in host resistance to malaria between susceptible A/J- and resistant C57BL-derived mice. In the present study, recombinant inbred strain analysis was performed with AXB/BXA recombinant inbred strains derived from A/J and C57BL/6 progenitors. Typing of 17 AXB/BXA recombinant inbred strains confirmed the unigenic control of inheritance in this particular strain combination and allowed us to demonstrate genetic linkage between the traits of resistance (defined as a prolonged survival and a low peak parasitemia) and the magnitude of splenomegaly. The influence of sex on the course of infection, which we previously reported in the examination of segregating populations (Stevenson et al., Infect. Immun. 38:80-88, 1982), was again demonstrated in the survey of RI strains.

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Section: Resultsmentioning

confidence: 91%

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Stevenson¹,

Skamene²

1985

Infect Immun

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“…Although genetically determined differences in survival time after infection with P. berghei are apparent among inbred strains of mice, infection with this species of murine Plasmodium is eventually lethal to all animals (9,16). Infection with another murine malaria species, P. chabaudi, which we used in this study, results in a much clearer distinction between susceptible and resistant mice.…”

Section: Discussionmentioning

confidence: 99%

“…Differences among inbred strains of mice in response to infection with various rodent malaria species have been observed. More than 25 years ago, Greenberg and co-workers (9) showed that the times until death of various inbred strains of mice after infection with Plasmodium berghei varied significantly. Although infection with this species of rodent malarial parasite is eventually lethal in all mice, resistant strains, such as C57BL mice, survive almost twice as long as susceptible mice, such as DBA/ 2.…”

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confidence: 99%

Murine malaria: genetic control of resistance to Plasmodium chabaudi

Stevenson¹,

Lyanga²,

Skamene³

1982

Infect Immun

140

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Strain variation in the level of resistance to malaria was investigated in inbred strains of mice after infection with Plasmodium chabaudi. When infected intraperitoneally with 106 P. chabaudi-parasitized erythrocytes, mice of 11 inbred strains could be separated into two groups by using survival time as the criterion; C57BL/6J, C57L/J, DBA/2J, CBA/J, and B10.AISgSn mice were found to be resistant to P. chabaudi, whereas A/J, DBA/1J, BALB/c, C3H/HeJ, AKRIJ, and SJL/J mice were susceptible. An examination of F1 hybrids revealed that resistance was dominant over susceptibility. A segregation analysis of backcross and F2 progeny derived from susceptible A/J and resistant B1O.AISgSn parental mice suggested that host resistance in this strain combination was genetically controlled by a single, dominant, non-H-2-linked gene. Inheritance of resistance

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“…Splenocyte culture was performed as previously described [25]. Briefly, spleens from normal and infected mice were removed aseptically and pressed through a sterile fine-wire mesh with 10 ml RPMI 1640 supplemented with 10% heat-inactivated fetal calf serum (FCS), 25 mM HEPES, 0.12% gentamicin, and 2 mM glutamine.…”

Section: Methodsmentioning

confidence: 99%

Age-Related CD4⁺CD25⁺Foxp3⁺Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria

et al. 2013

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Different functions have been attributed to CD4+CD25+Foxp3+ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-α, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.

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The Influence of Strain, Sex and Age of Mice on Infection with Plasmodium Berghei

Cited by 29 publications

References 0 publications

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Murine malaria: genetic control of resistance to Plasmodium chabaudi

Age-Related CD4⁺CD25⁺Foxp3⁺Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria

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The Influence of Strain, Sex and Age of Mice on Infection with Plasmodium Berghei

Cited by 29 publications

References 0 publications

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi

Murine malaria: genetic control of resistance to Plasmodium chabaudi

Age-Related CD4+CD25+Foxp3+Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria

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Age-Related CD4⁺CD25⁺Foxp3⁺Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria