The influence of surface charge on the tumor-targeting behavior of Fe₃O₄ nanoparticles for MRI

Abstract

Nanomedicine based tumor targeting therapy has emerged as a promising strategy to overcome the lack of specificity of conventional chemotherapeutic agents. The “passive” targeting caused by tumor EPR effect and...

Glutathione-sensitive mesoporous nanoparticles loaded with cinnamaldehyde for chemodynamic and immunological therapy of cancer

“…Once the nanoparticles were exposed to biological fluids, a large number of protein molecules would be adsorbed on their surface, known as protein corona. 60,61 This nanoparticle-protein interaction largely depends on the physicochemical properties of the particle surface, and can further alter the properties of nanoparticles. Since HA is presumably populated on the outer surface of the nanomedicine, it can thus be speculated that the nanomedicine gains a longer biological half-life by avoiding absorbing proteins.…”

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

“…Homotypic cancer cell membrane-modified NPs show stronger targeting capabilities than NPs modified with single ligands [ 20 ]. This is attributed to the multiple membrane receptors expressed on cancer cell membranes and their ability to avoid the formation of protein coronas [ 8 , 20 ]. Therefore, cancer cell membrane-encapsulated NPs can achieve better targeting toward tumors.…”

“…In addition, NPs can interact with proteins to form a protein corona, which affects the intended function of the NPs, resulting in changes of biological behavior and loss of function [ 6 – 7 ]. Moreover, the protein corona can accelerate RES/MPS uptake and interfere with the targeting ability of NPs [ 8 ].…”

Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”

“…[62] In the past two decades, this class of nanoparticles has been employed to establish different kinds of sensitive nanoprobes for accurate cancer diagnosis. [63] Interestingly, the longitudinal/transverse relaxivity of superparamagnetic iron oxide nanoparticles could be tuned through varying their particle diameter or aggregation status. [64] The smaller iron oxide nanoparticles tend to exhibit a paramagnetic property owing to the 5 unpaired electrons of Fe 3+ on the surface of nanoparticles, which can served as T 1 MRI contrast agents.…”