The fatigue behavior of bolted joints is critical to failure for many applications due to the high notch effect. Among other parameters, the lifetime is based on the influence of the surface system, consisting of corrosion protection and lubricant. With the intention of considering the surface system in the design and dimensioning process of bolted joints, experimental investigations are carried out systematically for an exemplary selected basecoat and various lubricant systems. The basis is given by fatigue tests supported by selected methods of material analysis for the fractographic evaluation. A reproducible method to determine the crack initiation as well as the crack propagation is developed and used for the evaluation of lubricant systems. Defined damage can be reproducibly assigned on the basis of a critical frequency change rate of the resonance test machine. A high durability of the friction in the load-bearing contact (e.g., greases) reduces the stress and delays the crack initiation. Lubricants which are able to creep (e.g., oil) slow down the crack propagation and increase the lifetime, which is proved by a higher number of cycles to failure and an increased fatigue strength.