The Influence of Surfactant on PLGA Microsphere Glass Transition and Water Sorption: Remodeling the Surface Morphology to Attenuate the Burst Release

Bouissou, Camille; Rouse, J.J.; Price, Robert; Walle, Christopher F. van der

doi:10.1007/s11095-006-0180-2

Cited by 110 publications

(61 citation statements)

References 51 publications

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“…The thermogram of PLGA shown in Fig. 5b reveals a glass transition temperature around 35-37°C which is in agreement with literature (25). The thermogram of physical mixtures of CPX and PLGA (weight ratio of 1:3) exhibited a glass transition which can be ascribed to PLGA and an exothermic peak due decomposition of CPX.…”

Section: Thermal Behavior Of the Microspheressupporting

confidence: 88%

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Cephalexin Microspheres for Dairy Mastitis: Effect of Preparation Method and Surfactant Type on Physicochemical Properties of the Microspheres

et al. 2010

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Abstract. The aim of this study was to evaluate the effects of preparation method and the type of surfactant on the properties of cephalexin (CPX) microspheres in order to obtain delivery systems suitable for the treatment of dairy mastitis. Microspheres were obtained using various preparation conditions and their physicochemical characteristics such as size, loading efficiency, morphology, and drug crystallinity were investigated. Antibacterial activity of microspheres from the optimum preparation condition was also studied. CPX microspheres were prepared by two different W/O/W emulsion solvent evaporation methods using PLGA as a matrix forming polymer. Several types of surfactants including nonionic, cationic, and anionic at different concentrations were used for preparation of the particles. The type and concentration of surfactant did neither affect the size nor morphology of the microspheres but showed a pronounced effect on the CPX encapsulation efficiency. It was found that Tween 80 showed the highest drug encapsulation efficiency (66.5%). Results from X-ray diffraction diffractograms and differential scanning calorimetry thermograms indicated that CPX entrapped in these microparticles was amorphous. Assessment of antibacterial activity showed that the obtained CPX microspheres exhibited good inhibition with minimum inhibitory concentration and minimum bactericidal concentration values of 128 µg/mL and 2,048 mg/mL against Staphylococcus aureus ATCC 25923, 512 µg/mL and 4,096 mg/mL against Escherichia coli ATCC 25922, respectively.

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Section: Thermal Behavior Of the Microspheressupporting

confidence: 88%

“…The obtained microspheres had a spherical shape and smooth surface, with some small pores. These pores can be attributed to the migration of inner aqueous droplets to the microsphere surface during emulsification (25).…”

Section: Morphological Characterizationmentioning

confidence: 99%

Cephalexin Microspheres for Dairy Mastitis: Effect of Preparation Method and Surfactant Type on Physicochemical Properties of the Microspheres

et al. 2010

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“…This can be partially attributed to the difference in hydrophobicity of the microspheres due to the different surfactant blends. The hydration of the particles was strongly influenced by the hydrophilicity of the surfactants, which enhances the degradation rate of the particles leading to faster release [2]. F4, which was relatively more hydrophobic than F6 and also had larger particle size, exhibited faster release with a very high burst release.…”

Section: Discussionmentioning

confidence: 99%

“…The technique requires surfactant as the main component in the fabrication. A number of studies employing the technique have shown that surfactants had effects on the particle physical aging [2], internal structure [3] and morphological characteristics, [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Surfactants on Plasmid DNA Stability and Release from Poly (D,L-lactide-co-glycolide) Microspheres

Doolaanea¹,

Ismail²,

Mansor³

et al. 2015

Trop. J. Pharm Res

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“…The preparation technique can vary depending on the application of the PLGA vehicles (Bouissou et al, 2006;Chaisri et al, 2009;Rosca et al, 2004). In the present work, PLGA (50:50) microspheres (3-0.5 m) have been prepared by double emulsion method.…”

Section: Plga -Particlesmentioning

confidence: 99%

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

D’Apolito

Taraballi

Minardi

et al. 2016

Medical Engineering & Physics

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Blood is a complex biological fluid composed of deformable cells and platelets suspended in plasma, a protein-rich liquid. The peculiar nature of blood needs to be considered when designing a drug delivery strategy based on systemically administered carriers. Here, we report on an in vitro fluid dynamic investigation of the influence of the microcapillary flow of red blood cells (RBCs) on micron sized carriers by high speed imaging methods. The experiments were carried out in a 50 m diameter glass capillary that mimicked the hydrodynamic conditions of human microcirculation. Spherical particles (-Ps), with sizes ranging between 0.5 and 3 m, were tested. Images of the flowing RBCs and -Ps were acquired by a highspeed/high-magnification microscopy. The transport and distribution of rigid particles in a suspension of RBCs under shear flow were followed for: i) the migration of RBCs towards the vessel centerline due to their deformability; ii) the cross-flow migration of -Ps towards the vessel wall due to their hydrodynamic interactions with RBCs; iii) the radial distribution of Ps in the presence of RBCs. This study suggests that the therapeutic efficacy of Ps could be ultimately affected by their interactions with the flowing RBCs in the vasculature.

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The Influence of Surfactant on PLGA Microsphere Glass Transition and Water Sorption: Remodeling the Surface Morphology to Attenuate the Burst Release

Cited by 110 publications

References 51 publications

Cephalexin Microspheres for Dairy Mastitis: Effect of Preparation Method and Surfactant Type on Physicochemical Properties of the Microspheres

Cephalexin Microspheres for Dairy Mastitis: Effect of Preparation Method and Surfactant Type on Physicochemical Properties of the Microspheres

Effect of Surfactants on Plasmid DNA Stability and Release from Poly (D,L-lactide-co-glycolide) Microspheres

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

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