The influence of surgical treatment and red blood cell transfusion on changes in antioxidative and immune system parameters in colorectal cancer patients

Surinėnaitė, Birutė; Prasmickienė, Gražina; Milašienė, Vida; Stratilatovas, Eugenijus; Didžiapetrienė, Janina

doi:10.3390/medicina45100102

Cited by 11 publications

(10 citation statements)

References 19 publications

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“…In our study, measuring serum MDA concentration in patients with various CRC stages we found the concentration of this oxidative stress marker to significantly increase to the third stage of the disease and as such persisted into the fourth stage of the disease. Similar results have been reported by Surinenaite et al , who found the concentration of MDA in serum of patients with CRC to be significantly higher in the third stage of the disease as compared to the second stage, and to have decreased significantly after surgical treatment when compared with the preoperative level ( 14 ).…”

Section: Discussionsupporting

confidence: 87%

The Relationship Between Serum Level of Malondialdehyde and Progression of Colorectal Cancer

Rašić

Akšamija

et al. 2018

ACC

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SUMMARY – The purpose of the study was to assess the level of serum malondialdehyde (MDA) concentration and its association with the stage and histopathologic sizes of colorectal cancer (CRC). One hundred and two patients having undergone surgical treatment of CRC between January 2014 and December 2015 were included in this cross-sectional study. The patients were divided into four groups (stage I-IV) according to the TNM classification. Control group included 30 subjects with no signs of malignancy and inflammatory diseases. In each patient, preoperative blood samples were obtained for determination of MDA concentration by ELISA immunoassay. Serum levels of MDA were progressively increased in patients with CRC, reaching the highest value in the fourth stage of CRC. Serum concentrations of MDA were significantly higher in pT4 group as compared with pT3 and pT2 groups of CRC patients (p<0.01). Significantly higher levels of MDA were found in the N1 and N2 groups of CRC patients as compared with N0 group, as well as in patients with metastatic disease as compared with those without metastasis (p<0.001). In conclusion, the progression of CRC is associated with a significant increase in serum MDA levels.

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Section: Discussionsupporting

confidence: 87%

The Relationship Between Serum Level of Malondialdehyde and Progression of Colorectal Cancer

Rašić

Akšamija

et al. 2018

ACC

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“…Mendonça et al ( 43 ) reported that higher MDA levels were found in the serum of patients with CRC at an advanced stage (III). Surinenaite et al ( 44 ) also reported that in 65 patients serum MDA level was more elevated in advanced than early stage CRC. The serum MDA level was significantly decreased after surgical treatments compared to pre-surgical status.…”

Section: Discussionmentioning

confidence: 92%

Plasma Lipidomic Signature of Rectal Adenocarcinoma Reveals Potential Biomarkers

et al. 2018

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BackgroundRectal adenocarcinoma (RAC) is a common malignant tumor of the digestive tract and survival is highly dependent upon stage of disease at diagnosis. Lipidomic strategy can be used to identify potential biomarkers for establishing early diagnosis or therapeutic programs for RAC.ObjectiveTo evaluate the lipoperoxidation biomarkers and lipidomic signature in the plasma of patients with RAC (n = 23) and healthy controls (n = 18).MethodsLipoperoxidation was evaluated based on malondialdehyde (MDA) and F2-isoprostane levels and the lipidomic profile obtained by gas chromatography and high resolution mass spectrometry (ESI-q-TOF) associated with a multivariate statistical technique.ResultsThe most abundant ions identified in the RAC patients were those of protonated phosphatidylcholine and phosphatidylethanolamine. It was found that a lisophosphatidylcholine (LPC) plasmalogen containing palmitoleic acid [LPC (P-16:1)], with highest variable importance projection score, showed a tendency to be lower in the cancer patients. A reduction of n − 3 polyunsaturated fatty acids was observed in the plasma of these patients. MDA levels were higher in patients with advanced cancer (stages III/IV) than in the early stages groups and the healthy group (p < 0.05). No differences in F2-isoprostane levels were observed among these groups.ConclusionThis study shows that the reduction in plasma levels of LPC plasmalogens associated with an increase in MDA levels may indicate increased oxidative stress in these patients and identify the metabolite LPC (P-16:1) as a putatively novel lipid signature for RAC.

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“…In patients with advanced inoperable CRC, serum MDA concentration is much higher than in those with primary CRC [35]. Surinenaite et al [36] also found that in 65 stage II/III CRC patients, serum MDA level was more elevated in stage III than stage II patients. The serum MDA level was significantly decreased after surgical treatments compared to presurgical status [36].…”

Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 88%

“…Surinenaite et al [36] also found that in 65 stage II/III CRC patients, serum MDA level was more elevated in stage III than stage II patients. The serum MDA level was significantly decreased after surgical treatments compared to presurgical status [36]. These observations suggest that MDA might relate to CRC carcinogenesis and progression.…”

Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 91%

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Cai

Dupertuis

Pichard

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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Recent findings CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to augmentation of oxidative stress and causes in consequence inflammation, which is one of the possible carcinogenic factors of CRC. End products of PUFAs might be used as biomarkers for CRC detection and surveillance for treatment. They also have cytotoxic effect in CRC cells. Experimental results suggest that v-3 PUFAs could increase the efficacy of radiotherapy and chemotherapy of CRC. SummaryLipid peroxidation, one factor of oxidative stress, might play a paramount role not only in carcinogenesis but also in potential therapeutic strategy on CRC. End products of lipid peroxidation, such as malondialdehyde, 4-hydroxy-2-nonenal, and isoprostanes, could be used as biomarkers for cancer detection, surveillance of treatment outcome and prognostic index for CRC patients. Furthermore, malondialdehyde and 4-hydroxy-2-nonenal have cytotoxic effect not only in normal cells but also in CRC cancer cells, which implies the potential role of PUFAs in CRC treatment.

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The influence of surgical treatment and red blood cell transfusion on changes in antioxidative and immune system parameters in colorectal cancer patients

Abstract: Summary. Objective. To determine the effect of surgical treatment and red blood cell transfusion on the parameters of antioxidative and immune systems in patients withMedicina (Kaunas) 2009; 45(10)

Cited by 11 publications

References 19 publications

The Relationship Between Serum Level of Malondialdehyde and Progression of Colorectal Cancer

The Relationship Between Serum Level of Malondialdehyde and Progression of Colorectal Cancer

Plasma Lipidomic Signature of Rectal Adenocarcinoma Reveals Potential Biomarkers

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

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