The influence of systemic inflammation on skeletal muscle in physically active elderly women

Wåhlin-Larsson, Britta; Carnac, Gilles; Kadi, Fawzi

doi:10.1007/s11357-014-9718-0

Cited by 42 publications

(39 citation statements)

References 43 publications

(50 reference statements)

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“…In the same study, the plasma concentration of the TLR4 agonist lipopolysaccharide and its binding protein also were significantly elevated in older participants, indicative of metabolic endotoxemia. In another study, when myoblasts isolated from vastus lateralis were exposed to the different sera from each elderly woman, the doubling time of myoblasts increased when cells were exposed to sera with high CRP levels, indicating that CRP contributes to the impairment of the proliferative rate of myoblasts in the elderly [94]. In a human study, muscle strength, as measured by walking speed, correlated with circulating IL-6 levels with the lowest levels in individuals with the highest walking speed [95].…”

Section: Sarcopeniamentioning

confidence: 97%

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Panickar¹,

Jewell²

2015

Hormone Molecular Biology and Clinical Investigation

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Aging in humans is associated with chronic low-grade inflammation (systemic), and this condition is sometimes referred to as "inflammaging". In general, canines also age similarly to humans, and such aging is associated with a decline in mobility, joint problems, weakened muscles and bones, reduced lean body mass, cancer, increased dermatological problems, decline in cognitive ability, reduced energy, decreased immune function, decreased renal function, and urinary incontinence. Each of these conditions is also associated with an increase in pro-inflammatory cytokines. An inflammatory state characterized by an increase in pro-inflammatory markers including but not restricted to tumor necrosis factor-α, interleukin-6, IL-1β, and C-reactive protein (CRP) is believed to contribute to or worsen a general decline in biological mechanisms responsible for physical function with aging. Nutritional management of inflammation in aging dogs is important in maintaining health. In particular, natural botanicals have bioactive components that appear to have robust anti-inflammatory effects and, when included in the diet, may contribute to a reduction in inflammation. While there are scientific data to support the anti-inflammatory effects and the efficacy of such bioactive molecules from botanicals, the clinical data are limited and more studies are needed to validate the efficacy of these ingredients. This review will summarize the role of dietary ingredients in reducing inflammatory molecules as well as review the evidence available to support the role of diet and nutrition in reducing chronic low-grade systemic inflammation in animal and human studies with a special reference to canines, where possible.

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Section: Sarcopeniamentioning

confidence: 97%

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Panickar¹,

Jewell²

2015

Hormone Molecular Biology and Clinical Investigation

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“…Numerous experiments have highlighted a potential role for "systemic" drivers. For instance, a reduction in the proliferative rate of myogenic cells was evident in cells exposed to sera from elderly women with elevated CRP levels [19]. Interestingly, elevated CRP levels in sera from elderly can affect the proliferative rate of other cells including endothelial cells [33].…”

Section: Discussionmentioning

confidence: 99%

“…Migrating cells were enzymatically harvested using dispase (BD Biosciences) and subcultured in growth medium. Harvested cells were purified by immunomagnetic cell sorting as previously described [19].…”

Section: Isolation and Purification Of Myoblasts From Human Biopsiesmentioning

confidence: 99%

“…Nonetheless, the specific inflammatory drivers of muscle atrophy and dysfunction remain poorly defined. In this respect, circulating acute phase C-reactive protein (CRP) is an established "biomarker" of systemic inflammation and is recognized as an important factor underlying several agerelated deleterious changes [15][16][17][18][19]. Thus, the possibility remains CRP itself could be a driver of muscle catabolism.…”

Section: Introductionmentioning

confidence: 99%

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Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly

Wåhlin-Larsson

Wilkinson

Strandberg

et al. 2017

Cell Physiol Biochem

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Background/Aims: Mechanisms underlying the relationship between systemic inflammation and age-related decline in muscle mass are poorly defined. The purpose of this work was to investigate the relationship between the systemic inflammatory marker CRP and muscle mass in elderly and to identify mechanisms by which CRP mediates its effects on skeletal muscle, in-vitro. Methods: Muscle mass and serum CRP level were determined in a cohort of 118 older women (67±1.7 years). Human muscle cells were differentiated into myotubes and were exposed to CRP. The size of myotubes was determined after immunofluorescent staining using troponin. Muscle protein synthesis was assessed using stable isotope tracers and key signalling pathways controlling protein synthesis were determined using western-blotting. Results: We observed an inverse relationship between circulating CRP level and muscle mass (β= -0.646 (95% CI: -0.888, -0.405) p<0.05) and demonstrated a reduction (p < 0.05) in the size of human myotubes exposed to CRP for 72 h. We next showed that this morphological change was accompanied by a CRP-mediated reduction (p < 0.05) in muscle protein fractional synthetic rate of human myotubes exposed to CRP for 24 h. We also identified a CRPmediated increased phosphorylation (p<0.05) of regulators of cellular energy stress including AMPK and downstream targets, raptor and ACC-β, together with decreased phosphorylation of Akt and rpS6, which are important factors controlling protein synthesis. Conclusion: This work established for the first time mechanistic links by which chronic elevation of CRP can contribute to age-related decline in muscle function.

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“…A synergistic and cumulative effect of these biomarkers may have exacerbated pathways contributing to greater muscle catabolism and reduced myogenesis [29], increased vascular pathology [8] and frailty [27]. Participants with higher levels of Component 3 had poorer health, and were more likely to drop out of the study, which may have underestimated the associations.…”

Section: Discussionmentioning

confidence: 99%

37grip Strength and Inflammatory Biomarker Profiles in Very Old Adults

et al. 2017

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Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness. Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment. Results: PCA identified three components, which explained 70% of the total variance in seven baseline biomarkers. Basal interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts.

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The influence of systemic inflammation on skeletal muscle in physically active elderly women

Cited by 42 publications

References 43 publications

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly

37grip Strength and Inflammatory Biomarker Profiles in Very Old Adults

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