The influence of temperature on the effects of lead and lithium in Mytilus galloprovincialis through biochemical, cell and tissue levels: Comparison between mono and multi-element exposures

Cunha, Marta; Cruz, I.; Pinto, João; Benito, Denis; Ruiz, Pamela; Soares, Amadeu M.V.M.; Pereira, Eduarda; Izagirre, Urtzi; Freitas, Rosa

doi:10.1016/j.scitotenv.2023.165786

Cited by 10 publications

(1 citation statement)

References 78 publications

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“…This result is not consistent with previous studies on Li effects on CbE, since varied responses of the enzyme have been reported in different animals. For instance, Prabha et al [ 85 ] found that Li has a positive effect on the release of CbE in rats, whereas Cunha et al [ 86 ] showed no significant effects of Li exposure on CbE in the mussel Mytilus galloprovincialis . More studies with longer exposure times are needed to better understand the effects of Li on these enzymes and the biological processes in which they are involved, as well as the mechanisms by which the response occurs.…”

Section: Discussionmentioning

confidence: 99%

Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinella arenarum (Hensel, 1867) as Model Organisms

Peltzer,

Cuzziol Boccioni,

Attademo

et al. 2024

Toxics

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The aim of this study was to evaluate the acute lethality and chronic sublethal effects of lithium (Li) on Rhinella arenarum tadpoles as model organisms. First a 96 h toxicity assay was performed by exposing tadpoles to Li concentrations from 44.08 to 412.5 mg L−1 to estimate the mortality, and lethal and sublethal effects. Another bioassay was carried out by exposing tadpoles to two environmentally relevant Li concentrations (2.5 and 20 mg L−1) for one and two weeks. The sublethal effects of Li on tadpoles were evaluated by analyzing biochemical, genotoxic, and physiological biomarkers. The mortality in Li-exposed tadpoles increased over time. The median lethal concentration (LC50) ranged from 319.52 (281.21–363.05) mg L−1 at 48 h to 66.92 (52.76–84.89) mg L−1 at 96 h. Exposure to Li at 2.5 and 20 mg L−1 induced alterations in enzymes related to detoxification, antioxidant, and hepatic mechanisms, endocrine disruption of thyroid hormones, genotoxicity, and effects on the physiology of the heart and gastrointestinal systems. Tadpoles exposed to the highest concentration in the chronic bioassay (20 mg L−1 Li), which is the concentration commonly recorded in Li mining sites, showed significant mortality after one week of exposure. These results warn about the high ecotoxicological risk of Li as a contaminant of emerging concern for amphibians.

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Section: Discussionmentioning

confidence: 99%