The influence of the dental papilla on the development of tooth shape in embryonic mouse tooth germs

Kollar, Edward J.; Baird, Grace R.

doi:10.1242/dev.21.1.131

Cited by 50 publications

(10 citation statements)

References 20 publications

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Section: Tooth Generation De Novomentioning

confidence: 99%

“…Epithelial-mesenchymal tissue interactions are the hallmark of tooth development and were first recapitulated in vitro by Kollar and Baird [33]. These authors generated tooth germs in vitro from recombined embryonic dental epithelium and mesenchyme [33]. When grafted into the anterior chamber of the mouse eye, the recombinants grew into properly patterned teeth with mineralized tissues, namely dentin and enamel [4].…”

Section: Tooth Generation De Novomentioning

confidence: 99%

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Biology Explaining Tooth Repair and Regeneration: A Mini-Review

Balic

2018

Gerontology

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The tooth is an intricate composition of precisely patterned, mineralized matrices and soft tissues. Mineralized tissues include enamel (produced by the epithelial cells called ameloblasts), dentin and cementum (produced by mesenchymal cells called odontoblasts and cementoblasts, respectively), and soft tissues, which include the dental pulp and the periodontal ligament along with the invading nerves and blood vessels. It was perceived for a very long time that teeth primarily serve an esthetical function. In recent years, however, the role of healthy teeth, as well as the impact of oral health on general well-being, became more evident. Tooth loss, caused by tooth decay, congenital malformations (tooth agenesis), trauma, periodontal diseases, or age-related changes, is usually replaced by artificial materials which lack many of the important biological characteristics of the natural tooth. Human teeth have very low to almost absent regeneration potential, due to early loss of cell populations with regenerative capacity, namely stem cells. Significant effort has been made in recent decades to identify and characterize tooth stem cells, and to unravel the developmental programs which these cells follow in order to generate a tooth.

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Section: Tooth Generation De Novomentioning

confidence: 99%

Section: Tooth Generation De Novomentioning

confidence: 99%

Biology Explaining Tooth Repair and Regeneration: A Mini-Review

Balic

2018

Gerontology

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“…This has been called embryonic induction and today this is believed to be the single most important mechanism of developmental regulation. Many embryologists showed already in the 1950´s and 1960´s that intercellular signaling is an important feature of tooth development, and that in teeth the signaling events take place mainly between the epithelial and mesenchymal tissue components (Fig 1, Kollar and Baird, 1969, Ruch et al, 1983.…”

Section: Signaling Molecules: Key Regulators Of Tooth Developmentmentioning

confidence: 99%

How to build a tooth? Developmental biology is revealing the instructions

Thesleff

2004

Tidende

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Få, om noen områder kan vise til en slik utvikling som bioteknologien har vært igjennom de siste årene. Metoder som for kort tid siden ble ansett som «science fiction», har i høyeste grad kvittet seg med «fiction»-begrepet, og molekylærbiologiske teknikker ser nå ut til å åpne for totalt nye muligheter innen både diagnostikk og behandling av sykdommer. Utviklingsbiologiens oppgave i denne sammenhengen er bl.a. å beskrive de prosesser og signalveier som fører til at ulike vev og organer dannes. Arbeidet som er gjort innen dette feltet har identifisert flere mekanismer som er nødvendige for vellykket og synkronisert utvikling av et organ eller sogar et individ. Det har også ført til identifisering av flere enkeltgener som, når de er uttrykt på feil sted eller til feil tid, kan føre til store misdannelser. Kartleggingen av disse mekanismene kan på sikt gi oss mulighet til å dyrke frem «kunstige» organer. Dette vil naturligvis kunne ha stor betydning ved agenesier eller patologiske prosesser. Tannanlegget er en klassisk og svært velegnet modell for å beskrive signalveiene som fører til dannelsen av et funksjonelt organ. Den systematiske forskningen som er utført innen dette feltet gjør også tennene til aktuelle kandidater for organer som lar seg fremstille kunstig. For som artikkelen antyder: Kjenner man mekanismene bak den naturlige utviklingen, har man også oppskriften. Professor Irma Thesleff har i en årrekke figurert blant verdens ledende utviklingsbiologer, med særlig fokus på mekanismer som regulerer tannutviklingen. Hun ble tildelt Anders Jahres store medisinske pris for 1999.

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“…In addition, the ectoderm is at the origin of the neural crest, a cell population that produces diverse tissues and is thus often considered as the fourth germ layer (Hall, 1998 , 2000 ). Vertebrate teeth, as a paradigmatic example of organogenesis, develop through reciprocal interactions between an epithelial component (derived from ectoderm or endoderm, and forming the enamel organ) and the underlying mesenchyme (neural crest‐derived, and forming the dental papilla) (Kollar & Baird, 1969 ; Balic & Thesleff, 2015 ; Balic, 2019 ; Yu & Klein, 2020 ) (Fig. 1A ).…”

Section: Introduction: Germ Layers and The Evolutionary Origin Of Teethmentioning

confidence: 99%

The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits

2021

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There are several competing hypotheses on tooth origins, with discussions eventually settling in favour of an ‘outside‐in’ scenario, in which internal odontodes (teeth) derived from external odontodes (skin denticles) in jawless vertebrates. The evolution of oral teeth from skin denticles can be intuitively understood from their location at the mouth entrance. However, the basal condition for jawed vertebrates is arguably to possess teeth distributed throughout the oropharynx (i.e. oral and pharyngeal teeth). As skin denticle development requires the presence of ectoderm‐derived epithelium and of mesenchyme, it remains to be answered how odontode‐forming skin epithelium, or its competence, were ‘transferred' deep into the endoderm‐covered oropharynx. The ‘modified outside‐in’ hypothesis for tooth origins proposed that this transfer was accomplished through displacement of odontogenic epithelium, that is ectoderm, not only through the mouth, but also via any opening (e.g. gill slits) that connects the ectoderm to the epithelial lining of the pharynx (endoderm). This review explores from an evolutionary and from a developmental perspective whether ectoderm plays a role in (pharyngeal) tooth and denticle formation. Historic and recent studies on tooth development show that the odontogenic epithelium (enamel organ) of oral or pharyngeal teeth can be of ectodermal, endodermal, or of mixed ecto–endodermal origin. Comprehensive data are, however, only available for a few taxa. Interestingly, in these taxa, the enamel organ always develops from the basal layer of a stratified epithelium that is at least bilayered. In zebrafish, a miniaturised teleost that only retains pharyngeal teeth, an epithelial surface layer with ectoderm‐like characters is required to initiate the formation of an enamel organ from the basal, endodermal epithelium. In urodele amphibians, the bilayered epithelium is endodermal, but the surface layer acquires ectodermal characters, here termed ‘epidermalised endoderm’. Furthermore, ectoderm–endoderm contacts at pouch–cleft boundaries (i.e. the prospective gill slits) are important for pharyngeal tooth initiation, even if the influx of ectoderm via these routes is limited. A balance between sonic hedgehog and retinoic acid signalling could operate to assign tooth‐initiating competence to the endoderm at the level of any particular pouch. In summary, three characters are identified as being required for pharyngeal tooth formation: (i) pouch–cleft contact, (ii) a stratified epithelium, of which (iii) the apical layer adopts ectodermal features. These characters delimit the area in which teeth can form, yet cannot alone explain the distribution of teeth over the different pharyngeal arches. The review concludes with a hypothetical evolutionary scenario regarding the persisting influence of ectoderm on pharyngeal tooth formation. Studies on basal osteichthyans with less‐specialised types of early embryonic development will provide a crucial test for the potential role of ectoderm in pharyngeal too...

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The influence of the dental papilla on the development of tooth shape in embryonic mouse tooth germs

Cited by 50 publications

References 20 publications

Biology Explaining Tooth Repair and Regeneration: A Mini-Review

Biology Explaining Tooth Repair and Regeneration: A Mini-Review

How to build a tooth? Developmental biology is revealing the instructions

The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits

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