The influence of the hypoglycemic agent glycorazmulin on the functional state of mitochondria in the rats with streptozotocin-induced diabetes

Asrarov, Muzaffar I.; Pozilov, Mamurjon Komiljonovich; Ergashev, Nurali A.; Rakhmatullaeva, M. M.

doi:10.14341/probl201460338-42

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…The aging of organism is accompanied by structural and functional modifications of macromolecules [70]. The changes that occur in the tissues of the organism under the development of diabetes mellitus are investigated both in laboratory animals using experimental models [9][10][11]17, 39, 40, 42, 45-47, [71][72][73][74][75][76][77] and directly in patients in the course of clinical examination [12,35,[78][79][80][81][82][83][84][85][86][87].…”

Section: Classification Of Diabetes Mellitusmentioning

confidence: 99%

“…A single doze varies from 50 to 200 mg/kg of body mass for mice and from 40 to 200 mg/kg for rats, depending on the breed [9,10,42]. Alloxan is injected intravenously, intraperitoneally, or subcutaneously [10,42,76].…”

Section: Experimental Models Of Diabetes Mellitusmentioning

confidence: 99%

“…For example, in 12 days after the intra-abdominal injection of streptozotocin to rats [76] the swelling of liver and pancreas mitochondria was fixed that led to the damage of mitochondria and ATP deficiency. In Ref.…”

Section: Different Tissuesmentioning

confidence: 99%

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Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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Abstract. Diabetes mellitus is a serious social and economic problem of modern society because it is widespread and fraught with numerous complications. Therefore, it is necessary to search for new methods of diabetes mellitus diagnostics and treatment and to improve the existing ones, which, in turn, requires thorough investigation of the disease development mechanisms, as well as elaboration of simple and reliable methods and criteria for detecting the complication precursors. In connection with the solution of these problems, in the paper we present an analytical review of recent publications devoted to the study of the changes of structural and optical properties of biological tissues under the conditions of diabetes mellitus development using in vitro models of glycated tissues, in vivo experimental models of diabetes in laboratory animals, and clinical studies.

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Section: Classification Of Diabetes Mellitusmentioning

confidence: 99%

Section: Experimental Models Of Diabetes Mellitusmentioning

confidence: 99%

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Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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“…In diabetes, the number of free fatty acids and various phospholipids increases in mitochondria (Sakamoto et al, 2000). In diabetes, along with the study of degenerative alterations in pancreatic β-cells, the study of mitochondrial liver disorders and their correction by plant substances is an important urgent problem (Asrarov et al, 2014). Since the study of ATP synthesis and ion transport systems in mitochondria as a source of cellular energy is considered extremely important in illuminating the mechanisms of diabetes and their treatment.…”

Section: Introductionmentioning

confidence: 99%

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

Pozilov¹,

Gayibov²,

Asrarov³

et al. 2022

J microb biotech food sci

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The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) and antiradical activity of rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways of correction of detected membrane damages with the use of gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that the rate of respiration of liver mitochondria in states V3 and V4 increases during STZ-induced diabetes, which significantly reduces the respiratory control (RC) and ADP/O coefficients in comparison with the control. The findings suggest that the uncoupling of respiration and oxidative phosphorylation takes place during STZ-induced diabetes. It was shown that in the conditions of STZ-induced diabetes, the rate of swelling of rat liver mitochondria is higher than of the healthy ones; this means that mPTP of rat liver mitochondria is in the open state. Gossitan recovers mPTP to the normal condition, thereby removing the effect of STZ on mitochondria. Gossitan (per os dose is 10 mg/kg of body weight, during 8 days) eliminates the detected functional disorders of rat liver mitochondria, probably due to its antioxidant properties.

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“…In the cell, such "targets" are mitochondrial membranes and structures localized in them, primarily the respiratory chain and mPTP) [1,2]. The role of mPTP is being actively discussed in the development of various pathologies, in particular, diabetes [3]. The formation of reactive oxygen species in the cell and the excessive activation of free radical oxidation processes underlie the development of diabetes mellitus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Plant Flavonoid Luteolin on a Mitochondrial Function in the Streptozotocin-induced Diabetic Rats

Komiljonovich¹,

Mamurovich²,

Abdulahadovna³

et al. 2020

AJBLS

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The state of the mitochondrial megapore (mitochondrial permeability transition pore-mPTP), respiration and oxidative phosphorylation of rat liver and pancreas mitochondria in streptozotocin (STZ) -induced diabetes were studied, considered the ways of correction of the detected membrane damage with the flavone luteolin isolated from the plant Inula caspica. It was shown that, under conditions of experimental diabetes mellitus, the rate of swelling of rat liver and pancreas mitochondria is higher than of the healthy ones; this means that mPTP of rat liver and pancreas mitochondria is in the open state in pathology. Luteolin recovers mPTP to the normal condition, thus removing the effect of STZ on mitochondria. It was also shown that, the respiration rate of liver and pancreatic mitochondria in the state 3 and state 4 states increases in STZinduced diabetes, which significantly reduces the respiratory control (RC) and ADP/O coefficients in comparison with the control. The data obtained indicate the disconnection of respiration and oxidative phosphorylation in STZ -induced diabetes. Luteolin (oral dose is 50 mg/kg of body weight, during 8 days) eliminates the detected functional disorders of rat liver and pancreas mitochondria, probably due to its antioxidant properties.

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The influence of the hypoglycemic agent glycorazmulin on the functional state of mitochondria in the rats with streptozotocin-induced diabetes

Cited by 4 publications

References 6 publications

Optical and structural properties of biological tissues under diabetes mellitus

Optical and structural properties of biological tissues under diabetes mellitus

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

Effect of the Plant Flavonoid Luteolin on a Mitochondrial Function in the Streptozotocin-induced Diabetic Rats

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