The influence of the <i>b</i>‐value combination on apparent diffusion coefficient based differentiation between malignant and benign tissue in cervical cancer

Hoogendam, Jacob P.; Klerkx, Wenche M.; Kort, G. A. P. de; Bipat, Shandra; Zweemer, Ronald P.; Sie-Go, Daisy M. D. S.; Verheijen, René H.M.; Mali, W. P. T. M.; Veldhuis, Wouter B.

doi:10.1002/jmri.22236

Cited by 43 publications

(32 citation statements)

References 29 publications

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“…[26,27]. We measured a linear character to our data and a tendency for equivalent ADC between b-value sets (Tables 1 and 2, Supplemental content), similar to Hoogendam et al, [28], which may have reflected ROI placement remote from the tumor periphery. ROI selection may also improve ADC variance, (e.g.…”

Section: Discussionmentioning

confidence: 96%

Variation in apparent diffusion coefficient measurements among women with locally advanced cervical cancer

Gladwish

Han

Foltz

2015

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 96%

Variation in apparent diffusion coefficient measurements among women with locally advanced cervical cancer

Gladwish

Han

Foltz

2015

Radiotherapy and Oncology

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“…A meta-analysis of the available studies conducted by Hou et al [7] shows that cervical cancer tissue shows restricted diffusion and lower ADC as compared to normal cervical tissue. Other studies have also shown that diffusion weighted MRI helps in precise demarcation of the tumour margins with reduced rates of overestimating the tumour volume (as in T2w in which both edema and mass are hyper intense) [8][9][10][11][12][13][14][15] . On conventional MRI the tumour is well delineated on T2 weighted sequence where it appears intermediate in signal intensity in the background T2 hypo intense cervical stroma.…”

Section: Manoharan D Et Al Dwi In Gynecological Malignanciesmentioning

confidence: 99%

Diffusion weighted imaging in gynecological malignancies - present and future

Manoharan¹,

Das²,

Aggarwal³

et al. 2016

WJR

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The management of gynaecological malignancies has undergone a significant change in recent years with our improved understanding of cancer biogenetics, development of new treatment regimens and enhanced screening. Due to the rapid blooming of newer methods and techniques in gynaecology, surgery and oncology the scope and the role of imaging has also widened. Functional imaging in the form of diffusion weighted imaging (DWI) has been recently found to be very useful in assessing various tumours. Its ability to identify changes in the molecular level has dramatically changed the diagnostic approach of radiologists which was solely based on morphological criteria. It can improve the diagnostic accuracy of conventional magnetic resonance imaging, lend a hand in assessing tumour response to treatment regimens and detect tumour recurrence with better spatial resolution, negative radiation and diagnostic accuracy compared to positron emission tomography scan. The ability to quantify the diffusion has also lead to potential prediction of tumour aggressiveness and grade which directly correlate with the patient prognosis and management. Hence, it has become imperative for a radiologist to understand the concepts of DWI and its present and evolving role. In this article we present a brief description of the basics of DWI followed by its role in evaluation of female gynaecological malignancies. Core tip: With rapidly evolving strategies in the management of the gynaecological malignancies today there is an increasing role of imaging to keep up with the pace of development and develop newer techniques which help in better management of the patient. Diffusion weighted imaging (DWI) is one such modality which helps in detecting changes at the molecular level and hence can help in better diagnosis of early cancers as well as in assessing response to treatment.

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“…The mean ADC value of cervical cancer lesions is lower than that of normal cervical tissue (112,(118)(119)(120)(121)(122)(123)(124)(125)(126) (123,(125)(126)(127). A prospective study of 61 patients with cervical cancer showed that all lymph nodes with a short-axis diameter larger than 5 mm were detected by DWI, regardless of whether they were benign or metastatic.…”

Section: Female Pelvis Applicationsmentioning

confidence: 99%

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

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Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

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The influence of the b‐value combination on apparent diffusion coefficient based differentiation between malignant and benign tissue in cervical cancer

Cited by 43 publications

References 29 publications

Variation in apparent diffusion coefficient measurements among women with locally advanced cervical cancer

Variation in apparent diffusion coefficient measurements among women with locally advanced cervical cancer

Diffusion weighted imaging in gynecological malignancies - present and future

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

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