The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

Abstract

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is 'dilution-fast' under physiological conditions of transudation or pathological conditions of inflammation.

Viral safety of Nanogam®, a new 15 nm‐filtered liquid immunoglobulin product

“…In contrast to inactivating, removing or partitioning steps, where there is a direct effect on the virus, either by physical or chemical disruption of the virus particle, or by physical removal of the virus from the product, in the event of immune neutralization, the potentially infectious virus remains present as a complex with antibodies. In theory, such complexes might dissociate and the virus may regain its infectivity [31].…”