The influence of the nanoparticles dilution upon the structure of molecular-coated magnetic fluid

Nanoparticulated magnetic drug delivery systems: Preparation and magnetic characterization

“…Blood, liver, and spleen volumes were quoted as 1.5, 2.3, and 0.2 mL, respectively. We argue that about 810 15 particles were captured by the blood mononuclear phagocyte cells (neutrophyls and monocytes) and retained in the liver and spleen. The blood mononuclear phagocyte cells containing nanoparticles is certainly removed out by the perfusion procedure before the MR data were recorded using the liver and spleen samples.…”

“…This finding allows us to estimate the effective half-life associated to the MNP absorption by the two compartments (liver plus spleen) as t 1/2 = 0.69/k c = 13.8 min. Mass-balance involving the two compartments (B and LS) indicates that about 810 15 nanoparticles were found in liver and spleen 60 min after injection, while in the same time window about 1610 15 particles left the bloodstream. Blood, liver, and spleen volumes were quoted as 1.5, 2.3, and 0.2 mL, respectively.…”

“…The use of magnetic colloids as a material platform to produce l-MDDS and u-MDDS will be briefly described as well. Indeed, besides MR [1][2][3] other techniques have been used to characterize magnetic colloids, magnetic nanocomposites and MDDS, providing assess to morphological/crystalline aspects [4][5][6][7][8][9], magnetic properties [10,11], and magneto-optical responses to DC/AC magnetic fields [12][13][14][15]. Applications of the l-MDDS discussed in this paper include cell-labeling [16][17][18], photodynamic therapy (PDT) [19][20][21][22], and magnetohyperthermia (MHT) of cancer cells and tissues [23][24][25].…”

Using Mössbauer spectroscopy as key technique in the investigation of nanosized magnetic particles for drug delivery

“…Different optical and magneto-optical techniques have been used to investigate nanosized magnetic particles as a pure powder sample, suspended as a colloid, or dispersed in a hosting template. For instance, the widely-used static magnetic birefringence is an exceptional technique in the investigation of magnetic fluids, once it provides information regarding the degree of nanoparticle agglomeration [22][23][24][25]. The recently used photoacoustic spectroscopy proved to be an excellent experimental technique to access information related to the molecular species attached to the nanoparticle surface [26,27].…”

“…This paper is focused on the description of the basic characterization of magnetic nanoparticles used to built a whole family of DDS, namely biocompatible magnetic fluids, magnetoliposomes, biocompatible magnetic nanocapsules, and biocompatible magnetic nanoemulsions. Besides Mössbauer spectroscopy [1][2][3][4][5][6][7][8][9][10] other techniques used to characterize the above-mentioned magnetic DDS include those related to the morphological/crystalline aspects [11][12][13][14][15][16][17], the magnetic and magnetooptical response to DC/AC magnetic fields [18][19][20][21][22][23][24][25], and visible/microwave excitation [26][27][28][29][30][31][32]. Applications of the l-DDS discussed in this paper include cell-labeling [33][34][35], photodynamic therapy (PDT) [36][37][38][39][40], and magnetohyperthermia (MHT) of cancer cells and tissues [41][42][43][44].…”