The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Gu, Guangzhi; Gao, Xiaoling; Hu, Quanyin; Kang, Ting; Liu, Zhongyang; Jiang, Mengyin; Miao, Deyu; Song, Qing; Yao, Lei; Tu, Yifan; Pang, Zhiqing; Chen, Hongzhuan; Jiang, Xinguo; Chen, Jun

doi:10.1016/j.biomaterials.2013.03.036

Biomaterials

2013

DOI: 10.1016/j.biomaterials.2013.03.036

|View full text |Cite

The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Guangzhi Gu¹,

Xiaoling Gao²,

Quanyin Hu³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2015

2022

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 127 publications

(92 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach was verified by using collagenase-coated NPs that produced a fourfold increase in the amount of 100 nm NPs delivered in MCTS. 73 NP diffusion in MCTS could also be improved by addition of cell-penetrating peptides on the NP surface such as RDG, 87,88 TAT or MPG. 64,65 It has been demonstrated that MPG-modified poly(d,l-lactic-co-glycolic acid) (PLGA) NPs exhibited a greater fluorescence intensity and a higher incorporation and diffusion in HeLa spheroids compared to unmodified PLGA NPs.…”

mentioning

confidence: 99%

“…65 Another possibility to achieve a higher NP penetration into MCTS was assessed by coadministration of the NP with the peptide iRGD, thus facilitating the NP extravasation and distribution. 88 The coadministration of a basic liposomal formulation of Taxol together with the iRGD peptide produced a threefold increase in drug accumulation and penetration into MCTS as compared with other liposomes or micelles especially designed to improve drug delivery in MCTS. 20 …”

mentioning

confidence: 99%

“…To estimate their distribution in spheroids, Oregon Green PTX was used. 20 More generally, fluorescent dyes such as rhodamine, 63,70,97 coumarin 87,88 or fluorescein isothiocyanate (FITC) are appropriate for this purpose. 95 Table 2 indicates that a great variety of NPs were designed to improve the anticancer drug delivery to tumors.…”

mentioning

confidence: 99%

“…On the basis of in vivo imaging in tumor-bearing mice, a strong parallel exists in the capacity of NPs to accumulate and to penetrate in cell spheroids as compared with tumor tissue. 65,66,87,88 For example, England et al 72 have shown that smaller citrate gold NPs exhibit enhancement of diffusion and accumulation in metastatic pancreatic adenocarcinoma spheroids (S2-VP10) compared to larger silica gold NPs. These results were also obtained in S2-VP10 orthotopic xenograft tumor and showed the predictive value of MCTS.…”

mentioning

confidence: 99%

“…The similarity between the evolution of spheroid volume and tumor growth after treatment constitutes a great advantage with respect to 2D cell models. 63,87,88,95 Predictive response of MCTS by mathematical models Nowadays, mathematical modeling is an invaluable tool for understanding the impact of cellular interactions on drug movement within MCTS. Indeed, the physical-chemical parameters of drug accumulation and distribution in tumor tissues can be determined by means of computational modeling.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

110

107

View full text Add to dashboard Cite

The increasing number of publications on the subject shows that nanomedicine is an attractive field for investigations aiming to considerably improve anticancer chemotherapy. Based on selective tumor targeting while sparing healthy tissue, carrier-mediated drug delivery has been expected to provide significant benefits to patients. However, despite reduced systemic toxicity, most nanodrugs approved for clinical use have been less effective than previously anticipated. The gap between experimental results and clinical outcomes demonstrates the necessity to perform comprehensive drug screening by using powerful preclinical models. In this context, in vitro three-dimensional models can provide key information on drug behavior inside the tumor tissue. The multicellular tumor spheroid (MCTS) model closely mimics a small avascular tumor with the presence of proliferative cells surrounding quiescent cells and a necrotic core. Oxygen, pH and nutrient gradients are similar to those of solid tumor. Furthermore, extracellular matrix (ECM) components and stromal cells can be embedded in the most sophisticated spheroid design. All these elements together with the physicochemical properties of nanoparticles (NPs) play a key role in drug transport, and therefore, the MCTS model is appropriate to assess the ability of NP to penetrate the tumor tissue. This review presents recent developments in MCTS models for a better comprehension of the interactions between NPs and tumor components that affect tumor drug delivery. MCTS is particularly suitable for the high-throughput screening of new nanodrugs.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

110

107

View full text Add to dashboard Cite

show abstract

Deeply Infiltrating iRGD‐Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT‐Mediated Chemosensitization and Strengthened Integrin Targeting‐Based Antimigration

Wang

Zhou

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

A limited infiltration and the subsequent low effective drug concentration result in poor chemotherapeutic outcomes against tumors, and even further promote tumor resistance and metastatic. Herein, iRGD‐modified graphene oxide (GO) nanosheets (IPHG) are developed for the intensive treatment of metastatic tumors using focus‐specific penetrated delivery together with photothermal therapy‐mediated chemosensitization and photothermal therapy‐strengthened integrin targeting‐based antimigration. In vitro and in vivo data verified the mechanism of the tumor‐selective infiltration of IPHG is based on a rigid 2D structure‐associated advantage regarding hemodynamics and endothelial contact, followed by iRGD‐endowed transendothelial and intratumoral transport. Once IPHG‐DOX‐penetrated 4T1 tumors are exposed to near‐infrared irradiation, hyperthermia stress and photothermal therapy‐elevated effective drug concentrations result in chemosensitization and prominent tumor suppression. Meanwhile, the specific binding of iRGD to integrins and photothermal therapy leads to the synergistic perturbation of cytoskeleton remodeling and subsequent impairment of cell motility and metastasis. The tailored design of IPHG validates a promising paradigm for drug delivery to combat tumor resistance and metastasis resulting from poor target access for single chemotherapy.

show abstract

Smart Nanoparticle‐Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy

Cheng

Santos

2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Tumor development and metastasis are closely related to the tumor microenvironment (TME). Recently, several studies indicate that modulating TME can enhance cancer immunotherapy. Among various approaches to modulating TME, nanoparticles (NPs) with unique inherent advantages and smart modified characteristics are promising candidates in delivering drugs to cancer cells, amplifying the therapeutic effects, and leading to a cascade of immune responses. In this review, several smart NP-based platforms are briefly introduced, such as responsive NPs, targeting NPs, and the composition of TME, including dendritic cells, macrophages, fibroblasts, endothelial cells, myeloid-derived suppressor cells, and regulatory T cells. Moreover, the recent applications of smart NP-based platforms in regulating TME and cancer immunotherapy are briefly introduced. Last, the advantages and disadvantages of these smart NP-based platforms in potential clinical translation are discussed.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Cited by 127 publications

References 47 publications

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Deeply Infiltrating iRGD‐Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT‐Mediated Chemosensitization and Strengthened Integrin Targeting‐Based Antimigration

Smart Nanoparticle‐Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy

Contact Info

Product

Resources

About