The Influence of the Pituitary and Adrenal Cortex on Resistance to Low Environmental Temperatures

The inhibition of histamine release by a pituitary-adrenal mechanism

“…These experiments may also explain why adrenalectomized animals are highly sensitive to trauma [Freed, 1932;Swingle & Parkins, 1935;Swingle, Parkins, Taylor & Hays, 1938; Hechter, Krohn & Harris, 1942;Noble & Collip, 1942]. Increased sensitivity to various stimuli was also observed in hypophysectomized animals by Tyslowitz & Astwood [1942], Noble & Collip [1942], Joseph, Schweitzer & Gaunt [1943 and Reiss, Macleod & Golla [1943]. The latter writers have also observed that corticotrophic hormone protects animals against shock-like conditions.…”

The Maintenance of Stability in the Newly Born: Part 2. Thermal Balance

“…Only at 14 days does the thyroid begin to play any part, and although the newborn animals soon begin to grow hair, this does not improve their thermal control till they are 18 days old. The adrenal glands may also -PlgIts kept \ be involved (Tyslowitz and Astwood, 1942;Hubble, at 120C 1957). Jailer (1953) thought that they only began to respond to the stimulus of cold about the sixteenth 1'6 '8 2'0 i2 24 day of life although they were capable of reacting to ACTH and adrenalin before this time.…”

The inhibition of histamine release by a pituitary‐adrenal mechanism

“…These experiments may also explain why adrenalectomized animals are highly sensitive to trauma [Freed, 1932;Swingle & Parkins, 1935;Swingle, Parkins, Taylor & Hays, 1938; Hechter, Krohn & Harris, 1942;Noble & Collip, 1942]. Increased sensitivity to various stimuli was also observed in hypophysectomized animals by Tyslowitz & Astwood [1942], Noble & Collip [1942], Joseph, Schweitzer & Gaunt [1943] and Reiss, Macleod & Golla [1943]. The latter writers have also observed that corticotrophic hormone protects animals against shock-like conditions.…”