The Influence of the Use of Benzodiazepines in the Frequency Falls in the Elderly

Softic, Albina; Beganlić, Azijada; Pranjić, Nurka; Sulejmanovic, Sevko

doi:10.5455/medarh.2013.67.256-259

Cited by 14 publications

(8 citation statements)

References 11 publications

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“…CNS effects, such as cognitive impairment and sedation, as well as drug interactions play a significant role in elderly patients [ 33 , 35 , 37 ]. Of particular concern is the increased risk of falls in elderly patients receiving benzodiazepine treatment [ 38 , 39 ], with potentially life-threatening consequences.…”

Section: Discussionmentioning

confidence: 99%

Off-label prescription of psychiatric drugs by non-psychiatrist physicians in three general hospitals in Germany

Lücke

Gschossmann²,

Grömer

et al. 2018

Ann Gen Psychiatry

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BackgroundOff-label prescribing of psychoactive drugs is a common practice in psychiatry. Here, we sought to investigate the frequency of off-label prescribing in a population of hospitalized patients with a somatic illness who were also suffering from a psychiatric pathology.MethodsUsing a prospective, observational design, we collected data from 982 hospitalized patients with a somatic illness for whom a psychiatric consultation was requested because of the presence of additional psychiatric symptoms. Data were collected at three hospitals in Germany. Demographic and clinical data, including the previous psychoactive medications and an assessment of the suitability of the previous medications, were recorded and analyzed.ResultsData on the previous psychiatric medications were available for 972 patients. In 16.6% of patients, at least one psychoactive drug had been prescribed off-label, 20.2% had received on-label medication, and 63.2% had not received any psychiatric medication. Among all patients receiving psychiatric medication, 45.1% had received off-label medication. The logistic regression analysis showed a significant influence of age on the likelihood of receiving off-label medication (p = 0.018). Benzodiazepines were the most frequent off-label prescription (25.8% of off-label prescriptions), followed by atypical antipsychotics (18.2%) and low-potency antipsychotics (17.2%). Notably, 57.1% of off-label prescriptions were judged to be ‘not indicated’ by experienced psychiatrists.ConclusionsOur data show a high frequency of the off-label prescription of psychoactive drugs by physicians treating patients with somatic illnesses in general hospitals. Because more than half of these cases were judged to be “not indicated”, these prescriptions indicate a potential risk to patients. Furthermore, the classes of drugs that were most frequently prescribed off-label, benzodiazepines and antipsychotics, both show a substantial risk profile, particularly for elderly patients.

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Section: Discussionmentioning

confidence: 99%

Off-label prescription of psychiatric drugs by non-psychiatrist physicians in three general hospitals in Germany

Lücke

Gschossmann²,

Grömer

et al. 2018

Ann Gen Psychiatry

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“…The association between benzodiazepines use and falls risk, or fall-related complications (i.e., injuries, fracture) has been reported by several researchers in the last two decades (Chang et al, 2011, Rossat et al, 2011, de Vries et al, 2013, Softic et al, 2013, Ballokova et al, 2014). One of the earlier studies in this area demonstrated an increased hospitalization rate from falls within 4 weeks after the first BDZs prescription, especially in older adults (Neutel et al, 1996).…”

Section: Introductionmentioning

confidence: 95%

The prevalence of benzodiazepines utilization and its association with falls among Saudi older adults; results from the Saudi national survey for elderly Health (SNSEH)

Aljawadi

Khoja

Alhammad

et al. 2018

Saudi Pharmaceutical Journal

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PurposeFirst, to determine benzodiazepines prevalence (BDZs) among Saudi older adults (SOA); Second, to quantify the association between BDZs use and falls among SOA. Third, to determine falls effect on all-cause mortality among SOA.MethodsThis is a cross-sectional study that used the Saudi National Survey for Elderly Health; a nationally-representative, population-based survey. Participants were asked about BDZs use and falls history during the 12 months prior to the interview. Demographics, medications, comorbidities and housing conditions were used as covariates. Multiple imputation was used to impute missing data. Modified poisson multivariable regression was used to study the association between BDZs and falls. Cox- proportional hazard regression was used to determine falls effect on mortality over nine years period.ResultsAmong 2946 SOA, BDZs prevalence was 4%. Around 13% reported falls. In the multivariable regression, relative risk (RR) of falls was 2 comparing BDZs users to non-users (95CI%: 1.02–3.99). Antidepressants (RR = 1.72; 95%CI: 1.10–2.74), laxatives (RR = 1.38; 95%CI: 1.11–1.7), low body mass index (RR = 1.94; 95%CI: 1.33–2.84), mild cognitive impairment (RR = 1.56; 95%CI: 1.21–2.03), high door steps (RR = 1.54; 95%CI: 1.23–1.93) and insufficient illumination (RR = 1.38; 95%CI: 1.11–1.71) increased falls risk. Lastly, the hazard ratio of falls on death was 1.48 (95%CI: 1.17, 1.89) over nine years.ConclusionDespite the recommendation against BDZs use among older adults, still there were subjects who were prescribed these drugs. falls are common among SOA. Preventive strategies such medication therapy management, nutrition improvement, elderly-friendly housing structures can reduce the prevalence of falls and consequent increase in mortality among SOA.

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“…Quando a substância em questão é capaz de provocar um efeito de grande intensidade e de gerar uma modificação importante da personalidade, é considerada psicotrópica. 36 As substâncias psicotrópicas têm sido usadas com diversos fins ao longo da história.…”

Section: Hemitartarato De Zolpidemunclassified

O Uso De Psicotrópicos Na Esquizofrenia: Uma Revisão De Literatura

Silva¹,

Silva²,

Guedes³

2022

Ciências Farmacêuticas Integrada Ao Processo De Cuidado Em Saúde 3

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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The Influence of the Use of Benzodiazepines in the Frequency Falls in the Elderly

Cited by 14 publications

References 11 publications

Off-label prescription of psychiatric drugs by non-psychiatrist physicians in three general hospitals in Germany

Off-label prescription of psychiatric drugs by non-psychiatrist physicians in three general hospitals in Germany

The prevalence of benzodiazepines utilization and its association with falls among Saudi older adults; results from the Saudi national survey for elderly Health (SNSEH)

O Uso De Psicotrópicos Na Esquizofrenia: Uma Revisão De Literatura

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