The influence of thioacetamide on the excretion of mercury in rats

Trojanowska, B; Piotrowski, J.; Szendzikowski, S

doi:10.1016/0041-008x(71)90130-x

Cited by 18 publications

(6 citation statements)

References 10 publications

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“…In addition, transcription and translation of RNA is enhanced which leads to increases in mRNA expression and protein levels. Together, these compensatory changes increase the delivery of solute to healthy nephrons and enhance the rate of solute uptake by tubular epithelial cells [3,4,5,6]. In general, the overall functional capacity of hypertrophied nephrons is enhanced as a mechanism to compensate for the loss of diseased/injured nephrons.…”

Section: Chronic Kidney Diseasementioning

confidence: 99%

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Orr

Bridges

2017

IJMS

307

110

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Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.

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Section: Chronic Kidney Diseasementioning

confidence: 99%

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Orr

Bridges

2017

IJMS

307

110

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“…Exposure of rats to nephrotoxic doses of Hg 2+ was found to enhance renal expression of Kim-1 and Ngal (Bridges et al 2014). As Hg-induced renal injury progresses, there is also a simultaneous rise in urinary excretion of mercuric ions (Clarkson and Magos 1967; Magos and Stoytchev 1969; Trojanowska et al 1971). …”

Section: Aging and Exposure To Mercurymentioning

confidence: 99%

The aging kidney and the nephrotoxic effects of mercury

Bridges

Zalups

2017

Journal of Toxicology and Environmental Health, Part B

104

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Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis, which may compromise renal plasma flow (RPF) and glomerular filtration rate (GFR). These alterations may reduce the functional reserve of the kidneys making them more susceptible to pathological events when challenged or stressed, such as following exposure to nephrotoxicants. An important and prevalent environmental toxicant that induces nephrotoxic effects is mercury (Hg). Since, exposure of normal kidneys to mercuric ions might induce glomerular and tubular injury, aged kidneys, which may not be functioning at full capacity, may be more sensitive to the effects of Hg than normal kidneys. Age-related renal changes and the effects of Hg in the kidney have been characterized separately. However, little is known regarding the influence of nephrotoxicants, such as Hg, on aged kidneys. The purpose of this review was to summarize known findings related to exposure of aged and diseased kidneys to the environmentally relevant nephrotoxicant, Hg.

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“…Mercury and number of renal cells in urine increased after administration of thio acetamide to the animals which previously received a dose of mercuric chloride (Trojanowska et al 1971).…”

Section: Discussionmentioning

confidence: 99%