The Influence of Thiouracil on Reproduction and Growth in the Rat

Barker, S. B.

doi:10.1677/joe.0.0060137

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…The present results are comparable to those reported to occur in rats. Barker (1949) noted a markedly reduced fertility with altered estrous cycles after thiourea treatment. Decreases in size and weights of mice ovaries and uteri have been observed by Dalton ct al.…”

Section: Gonadsmentioning

confidence: 98%

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The Effect of Thiourea, Administered by Immersion of the Maternal Organism, on the Embryos of Lebistes Reticulatus, With Notes on the Adult Gonadal Changes

Grosso¹

1961

The Biological Bulletin

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Section: Gonadsmentioning

confidence: 98%

“…The BMR is lowered in higher animals treated with goitrogenic compounds (Barker, 1949;Mackenzies, 1943;Leathern, 1945 ;Gordon ct al, 1946). Generally the decrease parallels that seen in surgically thyroidectomized animals.…”

Section: Gonadsmentioning

confidence: 99%

The Effect of Thiourea, Administered by Immersion of the Maternal Organism, on the Embryos of Lebistes Reticulatus, With Notes on the Adult Gonadal Changes

Grosso¹

1961

The Biological Bulletin

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“…The amount of information relating to effects of glucosinolates on reproduction in rats and mice is limited. Deleterious effects on reproductive performance of rats fed HG-RSM [9,41] and thiouracil, a known goitrogen [4,26,291, have been recorded. Feeding rapeseed protein concentrates is associated with specific problems of anorexia, weight loss and reduction in number of live pups at parturition [33].…”

Section: Ruts and Micesmentioning

confidence: 99%

Rapeseed meal‐glucosinolates and their antinutritional effects Part 5. Animal reproduction

Mawson

Heaney

Zduńczyk

et al. 1994

Nahrung

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Although there is no clear evidence to fully describe the mechanism involved in glucosinolate-related effects on animal reproduction, lowered fertility in animals fed diets with rapeseed meal (RSM) inclusion is related to glucosinolate content in the diet. Negative effects can result both from multidirectional action of glucosinolates, malnutrition of mother due to the thyroid dysfunction, transfer of goitrogenic compounds to foetus and reduced transfer of nutritive compounds (e.g. iodine) through the placenta. The degree of reproduction impairment depends both on glucosinolate content and on the type of animal. Pregnant female rats are sensitive to the presence of glucosinolates, and the first symptoms of fertility impairment and lowering of offspring survival rate may occur at low glucosinolate levels, e.g. with diets containing low glucosinolate rapeseed meal (LG-RSM). In the case of swine, the limiting value above which sows fertility may be impaired is 4 mumol of total glucosinolates per g diet and 8 mmol of daily intake of these compounds. Opinions on the permitted RSM inclusion in diet for hens are very divergent. Some authors recommend limiting of the RSM inclusion to 10%, while others did not find any lowering of egg production in hens fed with two- or three-fold greater RSM inclusion rates. Most long-term experiments with heifers, cows and ewes indicate that ruminants tolerate the level of glucosinolate in LG-RSM although feeding this fodder as the only high-protein concentrate component may lead to impaired fertility.

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Pathologische Anatomie und Physiologie der hypophysär-hypothalamischen Krankheiten

Orthner¹

1955

Nervensystem

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The Influence of Thiouracil on Reproduction and Growth in the Rat

Cited by 8 publications

References 6 publications

The Effect of Thiourea, Administered by Immersion of the Maternal Organism, on the Embryos of Lebistes Reticulatus, With Notes on the Adult Gonadal Changes

The Effect of Thiourea, Administered by Immersion of the Maternal Organism, on the Embryos of Lebistes Reticulatus, With Notes on the Adult Gonadal Changes

Rapeseed meal‐glucosinolates and their antinutritional effects Part 5. Animal reproduction

Pathologische Anatomie und Physiologie der hypophysär-hypothalamischen Krankheiten

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