The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity

Yılmaz, Yakup; Taşdemir, Haydar Ali; Paksu, Muhammet Şükrü

doi:10.1016/j.ejpn.2008.08.007

Cited by 38 publications

(45 citation statements)

References 23 publications

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“…To test the effectiveness of VPA on wound-induced hair growth, we daily applied VPA to the wound area (diameter = 0.5 mm) of C3H mice. The presence of epithelial stem cells in hair follicles around wound areas induces spontaneous hair cycling as previously reported [30], and VPA further significantly enhanced hair growth (Figures 6A and S10A) and the transition from telogen phase to anagen phase at the wound site as revealed by histological analysis (Figure 6B). The expression levels of fillaggrin, loricrin, and keratin 14 in wounds was also specifically increased by application of VPA for 14 d by both immunoblot and immunohistochemical analyses (Figures 6C and 6D).…”

Section: Resultssupporting

confidence: 79%

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

et al. 2012

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BackgroundAlopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3β inhibitor that activates the Wnt/β-catenin pathway, to promote hair re-growth in vitro and in vivo.Methodology/ Principal FindingsTopical application of VPA to male C3H mice critically stimulated hair re-growth and induced terminally differentiated epidermal markers such as filaggrin and loricrin, and the dermal papilla marker alkaline phosphatase (ALP). VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/β-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/β-catenin pathway. VPA analogs and other GSK3β inhibitors that activate the Wnt/β-catenin pathway such as 4-phenyl butyric acid, LiCl, and BeCl2 also exhibited hair growth-promoting activities in vivo. Importantly, VPA, but not MNX, successfully stimulate hair growth in the wounds of C3H mice.Conclusions/ SignificanceOur findings indicate that small molecules that activate the Wnt/β-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth.

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Section: Resultssupporting

confidence: 79%

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

et al. 2012

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“…Though valproic acid exerted a significant protective effect against pilocarpine‐induced seizures but it failed to cause a significant increase in hippocampal Zn concentration. This situation suggests an association between the side effects that develop during valproic acid treatment and zinc deficiency [43]. Indeed, valproic acid given to normal rats resulted in a significant decrease in hippocampal Zn concentration, which might be due to the ability of valproic acid to bind to Zn.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Role of Zinc in a Rat Model of Epilepsy

Baraka

Nabi

Ghotni

2011

CNS Neuroscience & Therapeutics

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“…Combinatorial treatment with both valproic acid and moderate levels of zinc showed an even greater therapeutic benefit than either intervention alone [82]. Although ongoing debate exists over whether treatment with antiepileptic drugs such as valproic acid causes secondary zinc deficiency, the aforementioned work by Baraka et al [79] supports this controversial theory [83]. Moderate dietary zinc supplementation therefore may act synergistically when ingested in combination with classical antiepileptic treatment.…”

Section: Zinc and Disorders Of The Central Nervous Systemmentioning

confidence: 99%

Zinc in the central nervous system: From molecules to behavior

2012

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The trace metal zinc is a biofactor that plays essential roles in the central nervous system across the lifespan from early neonatal brain development through the maintenance of brain function in adults. At the molecular level, zinc regulates gene expression through transcription factor activity and is responsible for the activity of dozens of key enzymes in neuronal metabolism. At the cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in both development and adulthood. Given these key roles, it is not surprising that alterations in brain zinc status have been implicated in a wide array of neurological disorders including impaired brain development, neurodegenerative disorders such as Alzheimer’s disease, and mood disorders including depression. Zinc has also been implicated in neuronal damage associated with traumatic brain injury, stroke, and seizure. Understanding the mechanisms that control brain zinc homeostasis is thus critical to the development of preventive and treatment strategies for these and other neurological disorders.

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The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity

Cited by 38 publications

References 23 publications

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

Investigating the Role of Zinc in a Rat Model of Epilepsy

Zinc in the central nervous system: From molecules to behavior

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