The influence of vitamin D deficiency on eradication rates of Helicobacter pylori

Yıldırım, Oğuzhan; Yıldırım, Tülay; Seçkin, Yüksel; Osanmaz, Pelin; Bilgiç, Yılmaz; Mete, Rafet

doi:10.17219/acem/65430

Cited by 34 publications

(45 citation statements)

References 27 publications

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“…Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Some studies have also found that serum vitamin D levels may have an impact on H. pylori eradication …”

Section: Discussionmentioning

confidence: 99%

“…The choice of H. pylori eradication scheme conformed to the Fifth Chinese national consensus report . A cut‐off value for serum vitamin D level was set at 10 ng/mL because a study from Turkey has reported that 10 ng/mL may be the cut‐off value that affects H. pylori eradication . Finally, a 13 C‐UBT was repeated between 4 and 8 weeks after the treatment was completed.…”

Section: Methodsmentioning

confidence: 99%

“…Vitamin D regulates the calcium and phosphorus metabolism needed for bone formation, and the influence of vitamin D on H. pylori infection and eradication rates has recently been widely investigated. Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane …”

Section: Introductionmentioning

confidence: 99%

“…Several clinical studies have illustrated that vitamin D analogs may have anti-H. pylori antimicrobial effects. [4][5][6][7][8][9][10] Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane. 11,12 However, the correlation between vitamin D levels and H. pylori has not been fully illustrated, and studies on the impact of serum vitamin D levels on H. pylori eradication were mostly of small sample sizes.…”

Section: Introductionmentioning

confidence: 99%

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Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Han

Yuan

et al. 2019

J of Digest Diseases

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Objectives This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates. Methods A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori− positive (H. pylori+) and 257 H. pylori‐negative (H. pylori−) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13C‐urea breath test (UBT) was performed for all the participants. The H. pylori+ patients were divided into two subgroups based on their serum vitamin D levels (<10 or ≥10 ng/mL). A second 13C‐UBT was performed between 4 and 8 weeks after 14‐day bismuth‐containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey. Results Serum vitamin D levels were significantly lower in the H. pylori+ group than in the H. pylori− group ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of <10 ng/mL and ≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183‐0.791, P = 0.010). Conclusions Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Han

Yuan

et al. 2019

J of Digest Diseases

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“…Repeated use of previously failed treatment combinations also contributes to poor eradication rates, highlighting the importance of efficient documentation of treatment histories. Treatment failure occurred more frequently in patients with 25‐OH vitamin D deficiency, whereas supplementing eradication therapy with vitamin C and E has no effect . A Japanese study found lower eradication rates with standard triple therapy in younger cohorts, perhaps reflecting poorer compliance …”

Section: Factors Of Treatment Failurementioning

confidence: 99%

Treatment of Helicobacter pylori infection in 2018

et al. 2018

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Treatment options for the eradication of Helicobacter pylori continue to evolve. There have been many guidelines for H. pylori treatment published, which may lead to some confusion. However, most are in agreement with the most recent iteration of the Maastricht treatment guidelines. Triple therapy is still the most frequently used treatment, especially in areas of low clarithromycin resistance. Its best results are achieved when taken for a minimum of 10 days and with high-dose acid suppression. Quadruple therapy is gaining in popularity particularly in areas with increasing resistance to standard triple therapy. Whether three antibiotics, or bismuth and two antibiotics are used, excellent eradication rates are achieved, albeit with increased side effects. Levofloxacin second-line therapy is widely used; however bismuth, when available, is an increasingly successful option. Sequential therapy is challenging in terms of compliance and is no longer recommended. This past year witnessed a notable increase in the number of studies based on antimicrobial susceptibility testing and tailored eradication therapy, reflecting the role of culture-guided treatment, which may well represent the future of H. pylori treatment and prevent the inappropriate use of antibiotics.

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Effect of Helicobacter pylori infection on vitamin D levels in old patients with sarcopenia

Bahşi

Atmış

Sürmeli

et al. 2020

Adv in Digestive Medicine

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We aimed to determine the possible relationship between sarcopenia, Helicobacter pylori and 25‐OH vitamin D. A total of 101 patients aged 65 years and over were included in the study, and grouped as sarcopenia (+) and (−) according to the skeletal muscle index (SMI) measured by bioelectrical impedance analysis (BIA). Also, patients were divided into two groups according to the presence and absence of H. pylori infection. There was no significant difference in the frequency of H. pylori infection in patients with and without sarcopenia (37.0% vs 29.7%; P = .485); 25‐OH vitamin D levels were significantly lower (18.25 [6.20‐32.00] μg/L vs 26.30 [9.33‐50.00] μg/L; P < .05) and the frequency of vitamin D deficiency (<20 μg/L) was significantly higher (80.0% vs 29.4%; P < .05) in sarcopenic patients with H. pylori infection than those without H. pylori infection. In addition, H. pylori infection was found to be associated with vitamin D deficiency in patients with sarcopenia (odds ratio: 12.53[1.48‐105.87]; P < .05). Within these findings, we concluded that the presence of H. pylori infection may lead to vitamin D deficiency in patients with sarcopenia.

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The influence of vitamin D deficiency on eradication rates of Helicobacter pylori

Cited by 34 publications

References 27 publications

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Treatment of Helicobacter pylori infection in 2018

Effect of Helicobacter pylori infection on vitamin D levels in old patients with sarcopenia

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