The influence of vitamin D analogs on calcification modulators, N-terminal pro-B-type natriuretic peptide and inflammatory markers in hemodialysis patients: a randomized crossover study

Hansen, Ditte; Rasmussen, Knud; Rasmussen, Lars Melholt; Bruunsgaard, Helle; Brandi, Lisbet

doi:10.1186/1471-2369-15-130

Cited by 26 publications

(19 citation statements)

References 57 publications

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“…In the present study, additional analysis revealed that there were no significant differences in NT-proBNP, CRP levels, and PTH levels between patients with and without vitamin D supplements or analogues treatment. Even though several previous studies showed that stimulation of vitamin D receptors reduced BNP levels, 46 – 51 some recent published data demonstrated that there was no significant association between vitamin D supplements and NT-proBNP concentrations in dialysis patients, 52 – 54 supporting the results of the present study.…”

Section: Discussionsupporting

confidence: 84%

Which Biomarker is the Best for Predicting Mortality in Incident Peritoneal Dialysis Patients

Lee

Kwon

et al. 2015

Medicine

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Although numerous previous studies have explored various biomarkers for their ability to predict mortality in end-stage renal disease (ESRD) patients, these studies have been limited by retrospective analyses, mostly prevalent dialysis patients, and the measurement of only 1 or 2 biomarkers. This prospective study was aimed to evaluate the association between 3 biomarkers and mortality in incident 335 ESRD patients starting continuous ambulatory peritoneal dialysis (CAPD) in Korea. According to the baseline NT-proBNP, cTnT, and hsCRP levels, the patients were stratified into tertiles, and cardiovascular (CV) and all-cause mortalities were compared. Additionally, time-dependent ROC curves were constructed, and the net reclassification index (NRI) and integrated discrimination improvement (IDI) of the models with various biomarkers were calculated. We found the upper tertile of NT-proBNP was significantly associated with increased risk of both CV and all-cause mortalities. However, the upper tertile of hsCRP was significantly related only to the high risk of all-cause mortality even after adjustment for age, sex, and white blood cell counts. Moreover, NT-proBNP had the highest predictive power for CV mortality, whereas hsCRP was the best prognostic marker for all-cause mortality among these biomarkers. In conclusions, NT-proBNP is a more significant prognostic factor for CV mortality than cTnT and hsCRP, whereas hsCRP is a more significant predictor than NT-proBNP and cTnT for all-cause mortality in incident peritoneal dialysis patients.

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Section: Discussionsupporting

confidence: 84%

Which Biomarker is the Best for Predicting Mortality in Incident Peritoneal Dialysis Patients

Lee

Kwon

et al. 2015

Medicine

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“…There are positive correlations between low 25-hydroxyvitamin D [25(OH)D; < 43 nmol/L] and obesity [ 10 ] as well as between 25(OH)D < 33–37.5 nmol/L and cardiovascular mortality [ 11 ]. Vitamin D has a protective effect on bones [ 12 ], anticancer [ 13 ] and anti inflammatory [ 14 ] effects and its receptors are present in pancreatic b cells and insulin sensitive tissues including skeletal muscle tissues [ 15 ]. Vitamin D repletion improves insulin and glucose homeostasis in animal models of vitamin D deficiency [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

Journal of Exercise Nutrition &Amp; Biochemistry

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PurposeThe purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.MethodsForty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.ResultsBody weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.ConclusionIt seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

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“…Stubbs et al reported that cholecalciferol supplementation altered calcitriol-responsive monocyte proteins and decreased inflammatory cytokines in 7 HD patients [79]. Conversely, recent randomized crossover trial did not find differences in IL-6, TNF-α and CRP following vitamin D analogs supplementation in chronic HD patients [80]. …”

Section: Correction Of Inflammation In Ckdmentioning

confidence: 99%

Update on Inflammation in Chronic Kidney Disease

2015

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Background: Despite recent advances in chronic kidney disease (CKD) and end-stage renal disease (ESRD) management, morbidity and mortality in this population remain exceptionally high. Persistent, low-grade inflammation has been recognized as an important component of CKD, playing a unique role in its pathophysiology and being accountable in part for cardiovascular and all-cause mortality, as well as contributing to the development of protein-energy wasting. Summary: The variety of factors contribute to chronic inflammatory status in CKD, including increased production and decreased clearance of pro-inflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, including those related to dialysis access, altered metabolism of adipose tissue, and intestinal dysbiosis. Inflammation directly correlates with the glomerular filtration rate (GFR) in CKD and culminates in dialysis patients, where extracorporeal factors, such as impurities in dialysis water, microbiological quality of the dialysate, and bioincompatible factors in the dialysis circuit play an additional role. Genetic and epigenetic influences contributing to inflammatory activation in CKD are currently being intensively investigated. A number of interventions have been proposed to target inflammation in CKD, including lifestyle modifications, pharmacological agents, and optimization of dialysis. Importantly, some of these therapies have been recently tested in randomized controlled trials. Key Messages: Chronic inflammation should be regarded as a common comorbid condition in CKD and especially in dialysis patients. A number of interventions have been proven to be safe and effective in well-designed clinical studies. This includes such inexpensive approaches as modification of physical activity and dietary supplementation. Further investigations are needed to evaluate the effects of these interventions on hard outcomes, as well as to better understand the role of inflammation in selected CKD populations (e.g., in children).

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The influence of vitamin D analogs on calcification modulators, N-terminal pro-B-type natriuretic peptide and inflammatory markers in hemodialysis patients: a randomized crossover study

Cited by 26 publications

References 57 publications

Which Biomarker is the Best for Predicting Mortality in Incident Peritoneal Dialysis Patients

Which Biomarker is the Best for Predicting Mortality in Incident Peritoneal Dialysis Patients

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Update on Inflammation in Chronic Kidney Disease

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