The Influence of Vitamin D on Parathyroid Activity and the Metabolism of Calcium and Citrate During Calcium Deprivation

Crawford, John D.; Gribetz, Donald; Diner, Wilma C.; Hurst, P Von; Castleman, Benjamin

doi:10.1210/endo-61-1-59

Cited by 38 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The normal plasma calcium of this strain of rats is higher than in other species. These findings are in agreement with those reported by Crawford et al (1957).…”

Section: Biochemical Changes In Bloodsupporting

confidence: 94%

“…Follis states that the absence of vitamin D from the calcium-deficient diet ' is not absolutely necessary ' in order to produce rickets in the rat. However, we can find only one report of the histological appearances of the bones resulting from a diet deficient solely in calcium, where adequate amounts of vitamin D were provided (Crawford, Gribetz, Diner, Hurst & Castleman, 1957). In these circumstances no osteoid borders appeared and radiological signs of rickets were not seen.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Structure and Metabolism in Calcium-Deficient Rats

Harrison¹,

Fraser²

1960

Journal of Endocrinology

106

View full text Add to dashboard Cite

Pure calcium deficiency produces osteoporosis, or bone atrophy, in rats, while vitamin D deficiency as well as calcium deficiency leads to osteomalacia, or thin bones with wide osteoid seams. The retention of a dose of strontium in the osteoporotic rats is greater than normal, and this indicates rapid bone formation. The immediate cause of the bone thinning must therefore be an increase in the rate of bone resorption, contrary to the classical concepts of osteoporosis.

show abstract

“…The normal plasma calcium of this strain of rats is higher than in other species. These findings are in agreement with those reported by Crawford et al (1957).…”

Section: Biochemical Changes In Bloodsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Bone Structure and Metabolism in Calcium-Deficient Rats

Harrison¹,

Fraser²

1960

Journal of Endocrinology

106

View full text Add to dashboard Cite

show abstract

“…The results are consistent with previous findings that growth is not always well maintained on meat or Cadeficient diets. Harrison and Fraser [17] and Crawford et al [9] found a significant decrease in weight in contrast to Copp and Sucker [8] and Scott et al [32]. Harrison and Fraser [17] and Jowsey [24] suggested that bone formation was increased on Ca-deficient diets.…”

Section: Discussionmentioning

confidence: 99%

Measurement of growth and resorption of bone in rats fed meat diet

Hammond

Storey

1969

Calc. Tis Res.

View full text Add to dashboard Cite

Different coloured, fluorescent bone-s~eking chemicals, viz., tetracycline, Alizarin Red S, and DCAF, have been administered sequentially to weanling rats and the rate of formation and resorption of bone measured from hard-ground cross sections of the upper third of the diaphysis of the fenmr. On a meat diet, bodily growth is significantly restricted for the first week and then recovery occurs. While bones grow they fail to mineralize normMly and rapidly become fragile and rarefied. Resorption of bone is at first slow, then accelerates for a period of 2--3 weeks to about 15 t~/day and then slows again. While the rate of bone formation is reduced relative to normal bone, resorption proceeds at approximately two to three times the rate of bone growth. Microradiographic studies confirm that while resorption occurs on the endosteal margin and formation proceeds on the periostcal aspect of meat fed Ca-deficient rats, new bone is less calcified than that in control animals. Key words':Divers agents chimiques, color6s, fluorcseents et se localisant dans les os, ~ savoir la tdtraeyclinc, l'alazazine rouge Set le DCAF, ont 6t6 administr6 en sdric s des rats sevr6s ct on mesur6 le taux de la formation et de la r6sorption osseuse sur les coupes transversales du tiers sup6rieur de la diaphyse. Ici la formation osseuse p6riostale s'effeetue progressivement avec pen de changement endost6al. Avec Mimentation carn6e, la croissancc des rats est significativcment restreinte pendant la premib, re semaine, mais se rdtablit ensuite. Bien qu'il y air croissance des os, ceux-ci ne se min6ralisent pas normalement ct ils dcviennent rapidement fragiles et amincis. ],a r6sorption osseuse est lente d'abord, puis s'aeeelbre pendant 2--3 semaines pour atteindre un taux de 15 tx par jour, aprbs quoi elle se rMentit de nouveau. Bien que le taux de formation osseuse soit r6duit, en comparaison avec celui des os normaux, la r6sorption s'effectue environ deux g trois fois plus rapidement que la eroissance osseuse. Des 6tudes microradiographiques sur des rats g r6gime earn6 mais carenc6s en cMcium ont permis la constatation suivante: tandis que la r6sorption s'effectue i~ la marge endost6ale et que la formation osseuse a lieu sur l'aspect pgriost6M, la matibre osseusc nouvellement form6e est moins calcifi6e que ehez les t@mins, Einige farbige, fhmreszierende, knochensuchende Chemikalien, z. B. Tetraeyelin, AlazarinRot S und CDAF, wurden nacheinander an entw6hnten Ratten verabreicht, worauf man die Knoehenbildungs-und Knochenresorptionswerte an hartgeschliffenen Sehnitten des oberen Drittels der Diaphyse gemessen hat. Hier finder fortsehreitend periostale Knochenbildung start, mit geringer Ver~nderung des Endosteums. Bei FleischdiS~t wird das KSrperwaehstum w~hrend der ersten Woche erheblich beschriinkt; danach aber normalisiert es sieh wieder. Obwohl die Knoehen noch wachsen, zeigen sie keine normMe Mineralisierung und werden sehnell zerbreehlieh und diinn. Die Knochenresorption ist anfangs langsam, dann beschleunigt For reprints: Prof. E. Storey,

show abstract

“…There is increasing evidence (6,16,17) that significant hyperparathyroidism exists in vitamin D-deficient rats maintained on a normal calcium intake. This appears to be a consequence of the hypocalcemia that results from the vitamin deficiency (6, 17) and can be prevented in large part by putting these animals on high calcium intakes (6,17 (17)], and the response of these animals measured in terms of phosphate excretion ( Figure 2, column 3; and Table II) and plasma phosphate (Table III) was similar to that seen in D-fed controls (Figure 2, column 1).…”

Section: Discussionmentioning

confidence: 99%