The influence of vitamin E-coated dialysis membrane on oxidative stress during a single session of on-line hemodiafiltration

Antić, Svetlana; Draginić, Nevena; Pilcevic, Dejan; Živković, Vladimir; Srejović, Ivan; Jeremić, Nevena; Petrović, Dejan; Jakovljević, Vladimir

doi:10.2298/vsp190730097a

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…Our previous research con rmed the fact that patients on hemodialysis are in higher risk for oxidative stress and anemia [33]. Antioxidant potential of SAE, as a speci c formulation, was recently demonstrated in an animal model of metabolic syndrome.…”

Section: Discussionsupporting

confidence: 55%

Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

et al. 2021

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The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110g/l, hemodialysis or hemodia ltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After nishing the treatment blood samples were taken in order to evaluate the effects of SAE on redox status. Several parameters of anemia and in ammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites signi cantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by bene cial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn`t improve in ammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has bene cial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 "retrospectively registered"

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Section: Discussionsupporting

confidence: 55%

Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

et al. 2021

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“…The previous studies had shown that selenium, zinc, or L-carnitine supplementation after each HD session for 2-3 months increase the capacity of enzymatic antioxidant protection and the status of malnutrition and decrease the resistance to EPO [ 36 – 38 ] which accentuate the fact that OS development leads to EPO resistance, as we concluded regarding the results of our study. Moreover, high-flux HD and post-dilution online hemodiafiltration with vitamin E-coated dialysis membranes significantly reduce OS and microinflammation, increase iron availability for erythropoiesis, reduce EPO resistance, and improve nutritional status, quality of life, and the outcome of patients treated with regular dialysis [ 39 – 41 ], which all together imply role of OS in the development of EPO resistance, as we concluded in our study.…”

Section: Discussionsupporting

confidence: 58%

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress

Jovic

Antić

Nikolić

et al. 2022

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) is considered a significant risk factor for the development of anemia in patients treated by regular hemodialysis (HD). Moreover, OS represents a risk factor for the development of erythropoietin (EPO) resistance in these patients. The aim of this study was to examine the role of OS regarding EPO resistance development in patients treated by regular HD. 96 patients treated with standard HD and on-line hemodiafiltration were included in this study. The patients were treated with short-acting and long-acting EPOs for anemia. The concentration of superoxide anion radical, hydrogen peroxide, thiobarbituric acid reactive substances, and nitric oxide in the form of nitrites and the activity of catalase, superoxide dismutase and reduced glutathione were measured in patients’ blood spectrophotometrically. Standard biochemical analysis, inflammatory markers, nutritional status, HD parameters, and erythropoietin resistance index were also determined. Patients with resistance to short-acting EPO had significantly lower concentration of hemoglobin in the blood and hematocrit value, a significantly higher serum ferritin concentration, and significantly lower catalase activity in erythrocytes than patients without EPO resistance. Patients with resistance to long-acting EPO have a significantly lower hemoglobin concentration in the blood, hematocrit values, and serum concentration of prealbumin and vitamin D, as well as significantly higher concentration of C-reactive protein, superoxide anion, and hydrogen peroxide concentration than those without resistance. OS significantly contributes to EPO resistance development. OS, higher ferritin and CRP levels, lower hemoglobin, hematocrit and prealbumin levels, and vitamin D deficiency represent significant risk factors for EPO resistance development in HD patients.

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“…Uremic toxins, altered endothelial function, chronic microinflammation, malnutrition, oxidative stress, resistance to erythropoietin, and anemia are the major non-traditional risk factors for the development of cardiovascular complications in this population [19,20]. Early detection and optimal control of these issues seem to play a key role in preventing cardiovascular co-morbidity in HD patients [21]. In recent years, direct cardiotoxicity of uremic toxins has been increasingly demonstrated, while a reduction in middle molecule retention appears to be independently associated with decreased risk of mortality [22].…”

Section: Discussionmentioning

confidence: 99%

Beta-2 microglobulin removal with postdilution online hemodiafiltration - comparison of three different dialysis membranes

2021

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Introduction/Objective. Accumulation of middle molecular weight uremic toxins causes various complications in chronic hemodialysis (HD) patients. Postdilution online hemodiafiltration (OL-HDF) efficiently removes these molecules. This study aimed to assess the effectiveness of three different dialysis membranes in removing ?2- microglobulin (b2m) within a single session of postdilution OL- HDF. Method. A prospective single-center study was carried out in 30 patients (23 males and 7 females, average age 54.87 ? 11.66 years, time on dialysis 4.95 ? 5.40 years) on maintenance HD. Each patient was followed for 3 consecutive weeks on OL-HDF with three different dialyzers: DiacapPro 19H, FX CorDiax 800, and Elisio 21H, randomly switched weekly. The reduction ratios (RR) of ?2m and albumin were compared individually. Results were analyzed with the Kolmogorov-Smirnov test, ANOVA, and the Kruskal-Wallis test. Results. The average convective volume for all patients was 21.38 ? 2.97 L/session. ?2-m RR was 70.86 ? 6.87%, 74.69 ? 6.51% and 70.04 ? 9.37% with Diacap Pro 19H, FX CorDiax 800 and Elisio 21H membrane respectively (p = 0.054). Albumin RR was 6.20 ? 2.12% with Diacap Pro 19H membrane, 6.01 ? 2.97% with FX CorDiax 800 membrane, and 6.46 ? 2.91% with Elisio 21H membrane (p = 0.812). Albumin loss was < 4.0g/dialysis treatment for all membranes. Conclusion. All investigated membranes effectively remove ?2-m in postdilution OL-HDF with a tolerable albumin loss. The highest ?2-m RR was determined for FX CorDiax 800 membrane, but with no statistically significant difference.

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The influence of vitamin E-coated dialysis membrane on oxidative stress during a single session of on-line hemodiafiltration

Cited by 8 publications

References 27 publications

Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress

Beta-2 microglobulin removal with postdilution online hemodiafiltration - comparison of three different dialysis membranes

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