The influence of volatile solvents on transport across model membranes and human skin

Oliveira, Gabriela; Hadgraft, Jonathan; Lane, Majella E.

doi:10.1016/j.ijpharm.2012.05.037

Cited by 60 publications

(54 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Saturated solutions of DF Na were prepared by adding excess DF Na to PG and DMSO followed by agitation of the solutions in an oven for 48 h at 32 ± 1ºC [15,16].…”

Section: Preparation Of Saturated Solutions Of Df Namentioning

confidence: 99%

The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum

Goh

Craig

Hadgraft

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

Drug permeation through the intercellular lipids, which pack around and between corneocytes, may be enhanced by increasing the thermodynamic activity of the active in a formulation. However, this may also result in unwanted drug crystallisation on and in the skin. In this work, we explore the combination of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the skin.Ex vivo permeation studies of saturated solutions of diclofenac sodium (DF Na) in two vehicles, propylene glycol (PG) and dimethyl sulphoxide (DMSO), were carried out in porcine ear skin. Tape stripping and ATR-FTIR spectroscopy were conducted simultaneously to collect spectral data as a function of skin depth. Multivariate data analysis was applied to visualise and categorise the spectral data in the region of interest (1700 -1500 cm -1 ) containing the carboxylate (COO -) asymmetric stretching vibrations of DF Na. 3Spectral data showed the redshifts of the COO -asymmetric stretching vibrations for DF Na in the solution compared with solid drug. Similar shifts were evident following application of saturated solutions of DF Na to porcine skin samples. Multivariate data analysis categorised the spectral data based on the spectral differences and drug crystallisation was found to be confined to the upper layers of the skin.This proof-of-concept study highlights the utility of ATR-FTIR spectroscopy in combination with multivariate data analysis as a simple and rapid approach in the investigation of drug deposition in the skin. The approach described here will be extended to the study of other actives for topical application to the skin. GRAPHICAL ABSTRACT KEY WORDSStratum corneum; Crystallisation; ATR-FTIR; Multivariate data analysis, Porcine skin 4

show abstract

“…Saturated solutions of DF Na were prepared by adding excess DF Na to PG and DMSO followed by agitation of the solutions in an oven for 48 h at 32 ± 1ºC [15,16].…”

Section: Preparation Of Saturated Solutions Of Df Namentioning

confidence: 99%

The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum

Goh

Craig

Hadgraft

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…All permeation studies were conducted using glass vertical Franz diffusion cells and porcine ear skin and followed procedures reported previously (Caon et al, 2010;Oliveira et al, 2012 (Parisi et al, 2015).…”

Section: In Vitro Permeation Studiesmentioning

confidence: 99%

“…Permeation studies, however, only allow the quantification of the amount of active which cross the skin barrier. Therefore for this study they are coupled with mass balance studies which provide information on both the amount of active which remains on the skin surface and that which is delivered inside the skin (Tsai et al, 1992;OECD, 2004;Oliveira et al, 2012). A range of binary systems which combined the single solvents with other CPEs were subsequently prepared and examined.…”

Section: Introductionmentioning

confidence: 99%

Topical delivery of hexamidine

Parisi¹,

Paz-Alvarez²,

Matts

et al. 2016

International Journal of Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Hexamidine diisethionate (HEX D) has been used for its biocidal actions in topical preparations since the 1950s. Recent data also suggest that it plays a beneficial role in skin homeostasis. To date, the extent to which this compound penetrates the epidermis has not been reported nor how its topical delivery may be where there are minor differences in molecular structures. We also believe that they underline the ongoing necessity for fundamental studies on the interaction of topical excipients with the skin.

show abstract

“…Coldman et al observed significant drug penetration enhancement from formulations with increasing ratio of the volatile solvent, possibly due to the higher magnitude of change in thermodynamic activity of permeant in these systems as well as higher drug--solvent drag into the SC [48]. Oliveira et al further evaluated the impact of volatile solvents on permeant transport across skin and documented enhanced penetration efficiency in the presence of volatile solvents such as ethanol [49]. In TSSs, the volatile solvent contact time and evaporation rate will dictate the driving force of drug into skin.…”

Section: Impact Of Volatile Solventmentioning

confidence: 99%

Spray-on transdermal drug delivery systems

Ibrahim

2014

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

TSS is easily applied, delivering flexible drug dosage and associated with lower incidence of skin irritation. TSS provides a fast-drying product where the volatile solvent enables uniform drug distribution with minimal vehicle deposition on skin. TSS ensures precise dose administration that is aesthetically appealing and eliminates concerns of residual drug associated with transdermal patches. Furthermore, it provides a better alternative to traditional transdermal products due to ease of product development and manufacturing.

show abstract

The influence of volatile solvents on transport across model membranes and human skin

Cited by 60 publications

References 22 publications

The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum

The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum

Topical delivery of hexamidine

Spray-on transdermal drug delivery systems

Contact Info

Product

Resources

About