The influence of water temperature on induced liver EROD activity in Atlantic cod (Gadus morhua) exposed to crude oil and oil dispersants

Lyons, M.C.; Wong, David; Mulder, I.; Lee, K.; Burridge, L.E.

doi:10.1016/j.ecoenv.2010.12.013

Cited by 33 publications

(17 citation statements)

References 29 publications

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“…Atlantic cod (Gadus morhua; Lyons et al, 2011), polar cod (Nahrgang et al, 2010) golden grey mullet (Liza aurata; Milinkovitch et al, 2011) and sea bass (Dicentrarchus labrax; Kerambrun et al, 2012). To the best of our knowledge, liver EROD activity levels have not previously been reported in lumpsucker.…”

Section: Erod Activitymentioning

confidence: 89%

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus)

Frantzen

Hansen

Geraudie

et al. 2015

Marine Environmental Research

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Section: Erod Activitymentioning

confidence: 89%

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus)

Frantzen

Hansen

Geraudie

et al. 2015

Marine Environmental Research

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“…In temperature-stressed salmon, lipids stored in muscle tissue are increasingly being used for maintenance energy metabolism [30]. EROD activity is temperature dependent in fish [41, 42], so if increased EROD activity over time is followed by increased transcription, a temperature effect on CYP1A transcription might be expected. In gills of rainbow trout ( Oncorhynchus mykiss ) held at 8 or 23°C for two weeks, heat stress up-regulated several drug-metabolizing protein transcripts including phase I and II enzyme transcripts such as CYP1A, CYP1C1, UGT2B17, and xenobiotic transporter ABCG2 [43], clearly suggesting a temperature effect on drug-metabolizing enzyme transcription in salmonids.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional responses to temperature and low oxygen stress in Atlantic salmon studied with next-generation sequencing technology

Olsvik¹,

Vikeså

Lie³

et al. 2013

BMC Genomics

109

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BackgroundWarmer seawater as a result of climate change may impose environmental challenges for Atlantic salmon aquaculture in its southernmost geographic range. Seawater temperatures above optimal level for growth may be reached in the warmest summer weeks. Caged fish can experience temperature and low oxygen saturation stress during such episodes, raising fish welfare and productivity concerns. In this work we compare the transcriptional responses in Atlantic salmon exposed to chronic high temperature (19°C) and low oxygen saturation (4-5 mg/L) stress.ResultsWe used next-generation sequencing and RT-qPCR to screen for effects, and focused on growth regulation and oxidative stress in fish exposed to sub-optimal conditions. Both prolonged temperature (45 days) and low oxygen (120 days) stress had a significant negative effect on growth. The main effect of heat stress appears to be a general reduced transcriptional rate in salmon liver, while mechanisms typically associated with responses induced by chemical drugs were stimulated. Heat stress significantly down-regulated several transcripts encoding proteins involved in the protection against oxidative stress, including CuZn SOD, Mn SOD, GPx1 and GR, as well as additional stress markers HIF1A, CYP1A, MTOR and PSMC2 (RT-qPCR data). In salmon held at low oxygen concentration for four months protein ubiquitination (protein catabolism) was the most strongly affected pathway. According to the RT-qPCR data, low oxygen stress significantly up-regulated the transcriptional levels of IGFBP1B and down-regulated the levels of GR. Pathway analysis suggests that high temperature and low oxygen saturation stress affects many similar mechanisms in Atlantic salmon. Based on the gene lists, six out of the top ten predicted upstream transcriptional regulators, 1,2-dithiol-3-thione sirolimus, CD437, 5-fluorouracil, HNF4A and NFE2L2, were similar between the two treatments.ConclusionsIn conclusion, temperature and low oxygen saturation stress affect many identical mechanisms in liver cells resulting in a metabolic depression, but these effects are not necessarily mediated through altered transcription of the same genes.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-14-817) contains supplementary material, which is available to authorized users.

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“…2005). The oil dispersal can markedly increase the hydrocarbon concentrations in test solutions as shown by the measured concentrations of polycyclic aromatic hydrocarbons (Lyons et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Histopathological Changes in the Livers of Rabbit Fish (Siganus canaliculatus) Following Exposure to Crude Oil and Dispersed Oil

Agamy

2012

Toxicol Pathol

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The present study aimed to assess the impact of acute exposure to crude oil, dispersed oil, and dispersant alone on the liver of the rabbit fish (Siganus canaliculatus). Histopathological effects in the liver were observed at different time points (3 to 21 days) and different concentrations (3-100% water accommodated fraction [WAF]) to simulate a range of possible oil pollution events. The main alterations observed in this study include lipid accumulation, necrosis, bile stagnation, megalocytosis, cholangitis, and spongiosis hepatis. The liver of fish exposed to WAF, dispersed oil, or dispersant showed significant histopathologic alterations compared with the control fish (Mann-Whitney U test; p < .01). Reaction pattern indices (circulatory, degenerative, proliferative, and inflammatory changes) of treated fish differed significantly from the control groups. There was a significant correlation between exposure time and the occurrence of most lesions (Spearman correlation; p > .05). The present study indicates that oil pollution can cause important alterations to livers of adult rabbit fish and that the dispersed oil is slightly more toxic than crude oil or dispersant.

show abstract

The influence of water temperature on induced liver EROD activity in Atlantic cod (Gadus morhua) exposed to crude oil and oil dispersants

Cited by 33 publications

References 29 publications

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus)

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus)

Transcriptional responses to temperature and low oxygen stress in Atlantic salmon studied with next-generation sequencing technology

Histopathological Changes in the Livers of Rabbit Fish (Siganus canaliculatus) Following Exposure to Crude Oil and Dispersed Oil

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