The influence on surface characteristic and biocompatibility of nano-SnO2-modified titanium implant material using atomic layer deposition technique

Hsu, Shu‐Han; Liao, Han-Ting; Chen, Rung-Shu; Chiu, Shang-Chan; Tsai, Feng-Yu; Lee, Ming‐Shu; Hu, Chia-Yuan; Tseng, Wan-Yu

doi:10.1016/j.jfma.2022.10.011

Cited by 7 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAO technology is a straightforward electrochemical surface modification technique that sparks a metal in an electrolyte at high potential and forms an oxide layer containing numerous microporous structures on the surface. Previous studies have confirmed that the hydrophilicity, cell proliferation, and in vitro osteogenic ability of solid-structured Ti2448 are improved after MAO treatment. , Moreover, when oxidized, Ti2448 alloy generates Nb 2 O 5 and SnO 2 , − which are conducive to osteogenesis. Therefore, MAO technology holds significant promise for enhancing the surface activity of 3D-printed Ti2448 scaffolds with a low elastic modulus.…”

Section: Introductionmentioning

confidence: 83%

Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus

Yang,

Wu,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Biomaterial scaffolds, including bone substitutes, have evolved from being primarily a biologically passive structural element to one in which material properties such as surface topography and chemistry actively direct bone regeneration by influencing stem cells and the immune microenvironment. Ti-6Al-4V(Ti6Al4V) implants, with a significantly higher elastic modulus than human bone, may lead to stress shielding, necessitating improved stability at the bone−titanium alloy implant interface. Ti-24Nb-4Zr-8Sn (Ti2448), a low elastic modulus β-type titanium alloy devoid of potentially toxic elements, was utilized in this study. We employed 3D printing technology to fabricate a porous scaffold structure to further decrease the structural stiffness of the implant to approximate that of cancellous bone. Microarc oxidation (MAO) surface modification technology is then employed to create a microporous structure and a hydrophilic oxide ceramic layer on the surface and interior of the scaffold. In vitro studies demonstrated that MAO treatment enhances the proliferation, adhesion, and osteogenesis capabilities on the scaffold surface. The chemical composition of the MAO-Ti2448 oxide layer is found to enhance the transcription and expression of osteogenic genes in bone mesenchymal stem cells (BMSCs), potentially related to the enrichment of Nb 2 O 5 and SnO 2 in the oxide layer. The MAO-Ti2448 scaffold, with its synergistic surface activity and low stiffness, significantly activates the anti-inflammatory macrophage phenotype, creating an immune microenvironment that promotes the osteogenic differentiation of BMSCs. In vivo experiments in a rabbit model demonstrated a significant improvement in the quantity and quality of the newly formed bone trabeculae within the scaffold under the contact osteogenesis pattern with a matched elastic modulus. These trabeculae exhibit robust connections to the external structure of the scaffold, accelerating the formation of an interlocking structure between the bone and implant and providing higher implantation stability. These findings suggest that the MAO-Ti2448 scaffold has significant potential as a bone defect repair material by regulating osteoimmunomodulation and osteogenesis to enhance osseointegration. This study demonstrates an optional strategy that combines the mechanism of reducing the elastic modulus with surface modification treatment, thereby extending the application scope of β-type titanium alloy.

show abstract

Section: Introductionmentioning

confidence: 83%

Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus

Yang,

Wu,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…It is also clear that the film is uniform, with no cracks or pores, Figure 3. This morphology generally enhances osseointegration [25][26][27].…”

Section: Structural and Morphological Characteristicsmentioning

confidence: 96%

Nanomechanical behavior, adhesion and wear resistance of tin oxide coatings for biomedical applications

Chayoukhi,

Gassoumi,

Dhifelaoui

et al. 2024

Materialwissenschaft Werkst

View full text Add to dashboard Cite

This study investigates the properties of tin oxide coatings employed in biomedical applications. The films were deposited on a clean glass substrate, preheated at 450 °C, applying the spray pyrolysis technique as the latter produces crystallized thin films without the need for further heat treatment. X‐ray diffraction analysis showed that tin oxide films had a tetragonal structure characterized by a preferential orientation (111). The measurements of reflectance and transmittance revealed a wide optical band gap of 4.0 eV. Nanoindentation tests showed that the tin oxide coating, with a hardness of 5.9 GPa and a Young's modulus of 78 GPa, exhibited elastic‐plastic behavior. In addition, tribological tests indicated that tin oxide coating had a very low coefficient of friction (μ=0.06), high wear resistance (wear rate 2.10−5 mm3 N−1 m−1) and good adhesion to the substrate (critical adhesion load of 5.55 N). It was also noticed that tin oxide thin films had antibacterial activity due to their nanocrystalline impurities. These properties make tin oxide perfectly acceptable for biomedical applications.

show abstract

“…These substrates exhibit different mechanical, optical, electrical, catalytic, and magnetic properties depending on the type of nanoparticle used for functionalization. As a result, new nanoparticle deposition techniques have been developed for this type of substrate [ 10 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. The most prominent ones are presented below.…”

Section: Deposition Of Nanomaterials On Metallic Substratesmentioning

confidence: 99%

“…In the study by Sheng-Hao et al [53], the substrate was deposited in a commercial ALD system with the precursor and H 2 O at a chamber temperature of 200 • C. The precursor container was heated to 70 • C, and the H 2 O container was kept at room temperature during the ALD processing. A cycle consisted of six steps: precursor 1/dosing time, soak time, evacuation time; precursor 2/dosing time, soak time.…”

Section: Atomic Layer Deposition (Ald)mentioning

confidence: 99%

Advancements in Nanoparticle Deposition Techniques for Diverse Substrates: A Review

Escorcia-Díaz,

García-Mora,

Rendón-Castrillón

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

Nanoparticle deposition on various substrates has gained significant attention due to the potential applications of nanoparticles in various fields. This review paper comprehensively analyzes different nanoparticle deposition techniques on ceramic, polymeric, and metallic substrates. The deposition techniques covered include electron gun evaporation, physical vapor deposition, plasma enriched chemical vapor deposition (PECVD), electrochemical deposition, chemical vapor deposition, electrophoretic deposition, laser metal deposition, and atomic layer deposition (ALD), thermophoretic deposition, supercritical deposition, spin coating, and dip coating. Additionally, the sustainability aspects of these deposition techniques are discussed, along with their potential applications in anti-icing, antibacterial power, and filtration systems. Finally, the review explores the importance of deposition purities in achieving optimal nanomaterial performance. This comprehensive review aims to provide valuable insights into state-of-the-art techniques and applications in the field of nanomaterial deposition.

show abstract

The influence on surface characteristic and biocompatibility of nano-SnO2-modified titanium implant material using atomic layer deposition technique

Cited by 7 publications

References 40 publications

Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus

Synergistic Amelioration of Osseointegration and Osteoimmunomodulation with a Microarc Oxidation-Treated Three-Dimensionally Printed Ti-24Nb-4Zr-8Sn Scaffold via Surface Activity and Low Elastic Modulus

Nanomechanical behavior, adhesion and wear resistance of tin oxide coatings for biomedical applications

Advancements in Nanoparticle Deposition Techniques for Diverse Substrates: A Review

Contact Info

Product

Resources

About