The Influence on the Capillary Blood Volume of the Optic Nerve Head Exerted by Beta-Blocking Agents with and without Intrinsic Sympatomimetic Activity

Robert, Y.; Hendrickson, Phillip

doi:10.1007/978-94-009-5516-5_19

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Whether the ocular perfusion pressures show a decrease or not, in our opinion it is important that the suscepti bility of the optic nerve head to increased IOP do not differ before and after application of timolol. Our results are confirmed by Robert and Hendrickson [ 1985] who used a different method (photodensitometry of the optic disc). These authors found that the blood flow, i.e.…”

Section: Discussionsupporting

confidence: 81%

Effect of Timolol on Optic Nerve Head Autoregulation

Pillunat¹,

Stodtmeister²,

Wilmanns³

et al. 1986

Ophthalmologica

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Healthy subjects show, in a special pressure compliance test of the optic nerve head, signs of autoregulation of optic nerve head circulation. In this test visual evoked response (VER) amplitudes were recorded during stepwise increased intraocular pressures. In the resulting VER amplitude/pressure curves glaucoma patients did not show the sign of autoregulation of optic nerve head circulation which is seen in healthy subjects. It is known that topically applied timolol maleate may affect optic nerve head circulation. Therefore the pressure compliance test was performed in 20 healthy eyes before and after 3 days of topically applied timolol maleate 0.5%. The aim of the study was to test the effect of topically applied timolol on optic nerve head autoregulation. In addition we determined the ocular perfusion pressures, heart rate and mean arterial blood pressure. While the ocular perfusion pressures show a slight, but statistically not significant, decrease under timolol, the systemic parameters and the autoregulation behavior did not change.

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Section: Discussionsupporting

confidence: 81%

Effect of Timolol on Optic Nerve Head Autoregulation

Pillunat¹,

Stodtmeister²,

Wilmanns³

et al. 1986

Ophthalmologica

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“…Die Autoren nehmen an, dass über die reduzierte Ziliar körperperfusion -vermittelt durch einen an den versorgenden Blutgefässen angreifenden Betablocker -eine reduzierte Kammerwas serbildung resultiert. Verschiedene andere Verfasser konnten jedoch keine lokal perfusionsmindernde Wirkung topisch applizier ter Betablocker nachweisen [4,8,10].…”

Section: Introductionunclassified

Einfluss unspezifischer und kardioselektiver Betarezeptorenblocker auf die Kammerwasserproduktion

Pillunat¹,

Stodtmeister²

1988

Ophthalmologica

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The aim of the present study was to show the effect of different topical beta-blocking agents on aqueous humor formation with a clinically practicable method. In a clinical, randomized, prospective double-blind study, 60 healthy volunteers were examined by means of oculopression tonometry according to Ulrich. The placebo was applied to 29 subjects; a nonselective beta-blocker (timolol maleate 0.5%) was given to 14 volunteers and 17 subjects received a cardioselective, beta-1-blocking agent (betaxolol-HCl 0.5%). On the 1st day, intraocular pressure (IOP) was lowered by the suction cup method and then we measured the time required for IOP to return to the initial value. The examination procedure of the 1st day was repeated on the 2nd day 3 h after application of the ophthalmic solution. After evaluation of the different groups, we could show that the recovery times in the placebo groups were comparable. Furthermore, we showed that both beta-blockers slow down the increase of IOP to the initial value. There was a statistically significant difference in recovery time between timolol and placebo. This difference was statistically not significant between beta-xolol and placebo.

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Hämodynamische Aspekte in der Glaukomtherapie

Pillunat¹

1993

Das Glaukom

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The Influence on the Capillary Blood Volume of the Optic Nerve Head Exerted by Beta-Blocking Agents with and without Intrinsic Sympatomimetic Activity

Cited by 4 publications

References 6 publications

Effect of Timolol on Optic Nerve Head Autoregulation

Effect of Timolol on Optic Nerve Head Autoregulation

Einfluss unspezifischer und kardioselektiver Betarezeptorenblocker auf die Kammerwasserproduktion

Hämodynamische Aspekte in der Glaukomtherapie

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