The influences of stenosis on the downstream flow pattern in curved arteries

Liu, Biyue

doi:10.1016/j.medengphy.2006.09.009

Cited by 56 publications

(26 citation statements)

References 33 publications

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“…The lumen flow generates shear forces that depend on the deformation and affects the equilibrium and thus the critical buckling pressure and buckling deformation. These interactions were ignored in many previous analyses of flow in curved vessels, and computational fluid dynamics were used to determine the flow field and wall shear stress [18][19][20]. To better understand the buckling behavior of arteries and its effect on the blood flow in the vessel lumen, it is necessary to analyze the artery buckling using the FSI modeling.…”

Section: Introductionmentioning

confidence: 99%

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Khalafvand

Han

2015

Journal of Biomechanical Engineering

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It has been shown that arteries may buckle into tortuous shapes under lumen pressure, which in turn could alter blood flow. However, the mechanisms of artery instability under pulsatile flow have not been fully understood. The objective of this study was to simulate the buckling and post-buckling behaviors of the carotid artery under pulsatile flow using a fully coupled fluid-structure interaction (FSI) method. The artery wall was modeled as a nonlinear material with a two-fiber strain-energy function. FSI simulations were performed under steady-state flow and pulsatile flow conditions with a prescribed flow velocity profile at the inlet and different pressures at the outlet to determine the critical buckling pressure. Simulations were performed for normal (160 ml/min) and high (350 ml/min) flow rates and normal (1.5) and reduced (1.3) axial stretch ratios to determine the effects of flow rate and axial tension on stability. The results showed that an artery buckled when the lumen pressure exceeded a critical value. The critical mean buckling pressure at pulsatile flow was 17-23% smaller than at steady-state flow. For both steady-state and pulsatile flow, the high flow rate had very little effect (<5%) on the critical buckling pressure. The fluid and wall stresses were drastically altered at the location with maximum deflection. The maximum lumen shear stress occurred at the inner side of the bend and maximum tensile wall stresses occurred at the outer side. These findings improve our understanding of artery instability in vivo.

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Section: Introductionmentioning

confidence: 99%

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Khalafvand

Han

2015

Journal of Biomechanical Engineering

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“…The treatment includes endovascular insertion of prosthesis whose role is to decrease stresses induced by blood flow on the impaired aorta's wall (Keyhani et al, 2009). Previously, Jung and Hassanein (2008), demonstrated in three-phase blood flow through a vessel that a higher blood leukocyte concentration correlates with a relatively low wall shear stress (WSS) near the stenosis having a high WSS which was in line with Liu et al (2007) who noticed that for the arteries with stenosis the WSS at the inner wall peaks at the neck of the stenosis and reaches the minimum in the post-stenosis region, and then recovers gradually in the downstream until it levels off (Liu et al, 2007).…”

Section: Introductionmentioning

confidence: 83%

Effects of stent-graft geometry and blood hematocrit on hemodynamic in Abdominal Aortic Aneurysm

Polańczyk¹,

Podyma²,

Stefańczyk³

et al. 2012

Chemical and Process Engineering

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CFD technique was used to determine the effect of a stent-graft spatial configuration and hematocrit value on blood flow hemodynamic and the risk of a stent-graft occlusion. Spatial configurations of an endovascular prosthesis placed in Abdominal Aortic Aneurysm (AAA) for numerical simulations were developed on the basis of AngioCT data for 10 patients. The results of calculations showed that narrows or angular bends in the prosthesis as well as increased hematocrit affects blood flow reducing velocity and WSS which might result in thrombus development.

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“…An alternative means for invasive flow measurements is presented by the calculation of models in which blood flow can be virtually simulated, a method that is called computational fluid dynamics (CFD). In fact, several in vitro studies [6,10,16,17,18] have shown that CFD allows reliable physiologic blood flow simulation and measurements of WSS, wall pressure, and mass flow. A detailed hemodynamic evaluation of disturbed flow in the post stenotic region may give additional insight of the progression of atherosclerosis and may have useful clinical value, such as early detection of a highly stenosed artery segment, prediction of future disease progression, and treatment planning 2.1 Artery reconstruction A Somatom Sensation 64 Scanner (Siemens Medical Systems, Erlangen, Germany) was used in non-enhanced spiral scan technique with a slice thickness of 0.75 mm, a table feed of 1 mm/s, and an increment of 2 mm (Fig.…”

Section: Methodsmentioning

confidence: 99%

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Bernad¹,

Bernad²,

Totorean³

et al. 2015

Int. J. DNE

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Effects of serial stenosis on coronary hemodynamics are investigated in the human right coronary artery (RCA) by blood flow analysis. The 3D reconstruction of the geometry of the stenosed coronary artery uses the multislice computerized tomography serial images method. Results of the numerical analysis present the hemodynamic characteristics of the serial stenosed coronary artery throughout the flow separation, pressure drop and wall shear stress. The pressure loss associated with recirculation region created in the vicinity of each constriction was found to be large. In two stenoses the corresponding pressure gradients are around 30 mmHg and correspond to the stenosis with fractional flow reserve-FFR < 0.7 (value associated to the severe stenosis). Distal to the stenosis, flow is associated with fluctuations in the wall shear stress and vorticity. Both FFR and CFD analysis help identify intermediate lesions that require intervention and reduce unnecessary procedures with potential complications.

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The influences of stenosis on the downstream flow pattern in curved arteries

Cited by 56 publications

References 33 publications

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Stability of Carotid Artery Under Steady-State and Pulsatile Blood Flow: A Fluid–Structure Interaction Study

Effects of stent-graft geometry and blood hematocrit on hemodynamic in Abdominal Aortic Aneurysm

Clinical important hemodynamic characteristics for serial stenosed coronary artery

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