The influences of TGF-β1 upon the human adenocarcinoma cell of lung A549 and cellular immunity

Li, Minjie; Wang, Xi; Chen, Ying; Li, Guangjian; Xiang, Bingquan; Wei, Xueqiang; Lei, Yonghong; Huang, Yunchao

doi:10.21037/atm-20-4437

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…Members of the TGF-b family are expressed in tissue-specific forms at different time points and, therefore, play an indispensable role in the development, homeostasis, and repair of most tissues in the body (77)(78)(79). All immune cells, entailing B cells, T cells, dendritic cells, and macrophages, secrete TGF-b, which in turn negatively modulates the proliferation, differentiation, and activation of immune cells through other cytokines (80)(81)(82)(83)(84). In addition, its signal disturbance has been linked to autoimmune diseases, inflammation, and cancer (85).…”

Section: Discussionmentioning

confidence: 99%

Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis

Xia

Chen

et al. 2022

Front. Immunol.

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Existing evidence demonstrates that coronavirus disease 2019 (COVID-19) leads to psychiatric illness, despite its main clinical manifestations affecting the respiratory system. People with mental disorders are more susceptible to COVID-19 than individuals without coexisting mental health disorders, with significantly higher rates of severe illness and mortality in this population. The incidence of new psychiatric diagnoses after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is also remarkably high. SARS-CoV-2 has been reported to use angiotensin-converting enzyme-2 (ACE2) as a receptor for infecting susceptible cells and is expressed in various tissues, including brain tissue. Thus, there is an urgent need to investigate the mechanism linking psychiatric disorders to COVID-19. Using a data set of peripheral blood cells from patients with COVID-19, we compared this to data sets of whole blood collected from patients with psychiatric disorders and used bioinformatics and systems biology approaches to identify genetic links. We found a large number of overlapping immune-related genes between patients infected with SARS-CoV-2 and differentially expressed genes of bipolar disorder (BD), schizophrenia (SZ), and late-onset major depressive disorder (LOD). Many pathways closely related to inflammatory responses, such as MAPK, PPAR, and TGF-β signaling pathways, were observed by enrichment analysis of common differentially expressed genes (DEGs). We also performed a comprehensive analysis of protein–protein interaction network and gene regulation networks. Chemical–protein interaction networks and drug prediction were used to screen potential pharmacologic therapies. We hope that by elucidating the relationship between the pathogenetic processes and genetic mechanisms of infection with SARS-CoV-2 with psychiatric disorders, it will lead to innovative strategies for future research and treatment of psychiatric disorders linked to COVID-19.

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Section: Discussionmentioning

confidence: 99%

Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis

Xia

Chen

et al. 2022

Front. Immunol.

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“…TGF-β1 is a complex cytokine, which is closely related to tumor. In the process of tumor cell proliferation, its regulatory role has two sides [ 15 ]. In the early stage of cancer, TGF-β inhibits the growth of tumor cells and induces tumor cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Correlation and significance of COX-2, Ki67, VEGF and other immune indexes with the growth of malignant pulmonary nodules

Guo

Xue

Zhao

et al. 2022

J Cardiothorac Surg

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Objective This study intends to explore the factors affecting the growth of pulmonary nodules in the natural process by immunohistochemical method. Methods 40 cases of pulmonary nodules followed up for more than 3 years were divided into growth group (n = 20) and stable group (n = 20). The expressions of cyclooxygenase-2 (COX-2), Ki67, vascular endothelial growth factor (VEGF), CD44V6, epidermal growth factor receptor (EGFR), double microsome 2 (MDM2) and transforming growth factor (TGF)-β1 in pulmonary nodules were detected by immunohistochemical method so as to explore the relationship between it and the growth of pulmonary nodules. Results Compared with stable pulmonary nodules, the positive rates of COX-2, Ki67 and VEGF in the growth group were 85%, 80% and 55%, respectively. There was significant difference between the stable group and the growth group (P < 0.05). The correlation between other indexes and the growth of pulmonary nodules was not statistically significant (Pcd44v6 = 0.104;PEGFR = 0.337; PMDM2 = 0.49; PTGF-β1 = 0.141). In the subgroup of patients with non-invasive lung cancer, there was a correlation between VEGF and the growth of pulmonary nodules (P < 0.05). Conclusion The high expression of COX-2, Ki67 and VEGF proteins may be significantly related to the growth of pulmonary nodules, and VEGF may be an important factor affecting the growth of malignant pulmonary nodules. This study intends to provide a research direction for further searching for the essential causes of the growth of pulmonary nodules.

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“…Bacterial biofilm refers to the membrane-like multibacterial complex comprising bacterial cells and aqueous polymeric matrix (mainly exopolysaccharides) secreted by them, which adheres to the body surface during bacterial growth (20). During evolution, a fine adhesion mechanism is gradually formed in most bacteria, which secrete the matrix and form the membranous substances adhering to the surface of lesion, thereby producing the complex group of biofilms (21).…”

Section: The Correlation Between Tgf-β1 and Cvc-centered Staphylococcus Epidermidis Biofilm Formation In Tree Shrewsmentioning

confidence: 99%

“…Transforming growth factor-β1 (TGF-β1), a potent immunosuppressor, is highly expressed in a variety of tumors (5). TGF-β1 can inhibit the proliferation and function of lymphocytes and is one of the major reasons behind immune dysfunction in patients with malignant tumors (6).…”

Section: Introductionmentioning

confidence: 99%

The effects of TGF-β1 on staphylococcus epidermidis biofilm formation in a tree shrew biomaterial-centered infection model

Lei¹,

Xu²,

Peng³

et al. 2021

Ann Transl Med

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Background: Transforming growth factor-β1 (TGF-β1) has a wide range of biological functions. It antagonizes lymphocyte response, inhibits pro-inflammatory cytokines, and serves as a signal to turn off the immune response and inflammatory response. To study the correlation between TGF-β1 and T helper (Th)1/ Th2 cytokine levels in tree shrews, and to explore the effects of different levels of TGF-β1 on central venous catheter (CVC)-centered Staphylococcus epidermidis biofilm formation in tree shrews.Methods: Tree shrews were injected with different concentrations of TGF-β1, and venous blood was drawn after 48 h to measure the levels of Th1 and Th2 cytokines. A CVC was placed into the femoral vein, and TGF-β1 at different concentrations and PIA− (ATCC12228) and PIA+ (ATCC35984) standard strains of Staphylococcus epidermidis were injected into the tree shrews to establish a biomaterial-centered infection (BCI) model. After 72 h, the CVC was removed, and biofilm formation was detected using the API bacterial identification system, semi-quantitative biofilm formation assay, and scanning electron microscopy.Results: In the groups treated with TGF-β1 at different concentrations, the levels of Th1 cytokines interleukin-2 (IL-2), tumor necrosis factor (TNF), and interferon-γ (IFN-γ) were lower than those of normal group, while the levels of Th2 cytokines IL-6, IL-4 and IL-10 were higher than those of normal group. In the TGF-β1 groups at different concentrations, the positive rate of Staphylococcus epidermidis ATCC35984 biofilm formation was higher than that in non-TGF-β1 group, while there was no significant difference in the positive rate of Staphylococcus epidermidis ATCC12228 biofilm formation compared with that of the non-TGF-β1 group.Conclusions: TGF-β1 causes the imbalance of Th1/Th2 cytokines and Th1/Th2 shift in tree shrews, leading to Th1 cell-led decline in cellular immune function. TGF-β1 promotes PIA+ Staphylococcus epidermidis biofilm formation in the tree shrew BCI model, but it has no significant influence on PIA-Staphylococcus epidermidis biofilm formation on the surface of CVCs.

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The influences of TGF-β1 upon the human adenocarcinoma cell of lung A549 and cellular immunity

Cited by 4 publications

References 14 publications

Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis

Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis

Correlation and significance of COX-2, Ki67, VEGF and other immune indexes with the growth of malignant pulmonary nodules

The effects of TGF-β1 on staphylococcus epidermidis biofilm formation in a tree shrew biomaterial-centered infection model

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