Annotation. Knowing the exact position of the openings in the facial part of the skull, through which vessels and nerves pass, is extremely important for performing operative, reconstructive and other interventions in this area. Since there is considerable variability in the position of the supraorbital (SOH), infraorbital (IOH) and submental (SMOH) holes, the purpose of our work is to determine the exact spatial position of the above-mentioned holes relative to cranial points and bony landmarks depending on the facial index of a mature person. Studies were conducted on 52 bone preparations of skulls using commonly accepted instruments and 60 CT images of mature Caucasians without pathology of the bones of the facial part of the skull. Studies on CT images were carried out using a virtual Anatomage table using the Launching Table 6.0 Application program. Statistical methods were used to analyze the obtained measurement results in our research, which was carried out with the help of the Microsoft Excel 2010 © licensed program package and with the help of the “STATISTYCA” program. To determine the interdependence of features in the general population, a correlation analysis was performed. In the course of the study, we determined the average values of the distances from the SOH, IOH and SMOH to the following craniological points: nasion (n.), nasospinale (ns) and frontomalare orbitale (fmo) depending on the facial index. Analyzing the obtained data, significant differences in the position of the above-mentioned openings to the corresponding craniological points were clearly observed depending on the type of structure of the facial part of the skull. There was an increase in the distances from the SOH and IOH to the nasion point and the frontmolar orbital point in euryprosopics, and smaller results were obtained in leptoprosopics. The average values of the distance indicators from the SOH, IOH and SMOH to the nasolabial point were significantly larger in leptoprosopics, in contrast to euryprosopics. When determining the size of the supraorbital margin and the distance from the SOH to the supraorbital margin, euryprosopics prevailed. The obtained results of measuring the distance from the IOH to the edge of the upper jaw and from the SMOH to the upper and lower edges of the lower jaw indicate an increase in these distances in long-faced (leptoprosopic) in contrast to wide-faced (euryprosopic). The results of the study indicate the dependence of the position of the openings of the facial part of the skull on the facial index, which will make it easier in clinical practice to determine the position of the nerves and vessels coming out of these openings.