The infrapatellar fat pad from diseased joints inhibits chondrogenesis of mesenchymal stem cells

Wu, Wei; Rudjito, Resti; Fahy, Niamh; Verhaar, Jan A N; Clockaerts, S.; Bastiaansen-Jenniskens, Y.M.; Osch, Gerjo J.V.M. van

doi:10.22203/ecm.v030a21

Cited by 17 publications

(13 citation statements)

References 14 publications

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“…A PRISMA flowchart was created for transparency of report selection (►Fig. 3). A total of 395 reports were identified.…”

Section: Methodsmentioning

confidence: 99%

“…injuries and osteoarthritis. [3][4][5][6] Biomechanically, the fat pad is a mobile structure that can change in shape, size, position, and pressure during range of motion of the knee, and therefore, helps stabilize the patella and the patellar tendon, to prevent pinching of the synovial membrane. [7][8][9][10] However, the infrapatellar fat pad can also act as an important source of anterior knee pain.…”

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confidence: 99%

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Infrapatellar Fat Pad Impingement: A Systematic Review

et al. 2017

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Infrapatellar fat pad impingement represents a source of anterior knee pain that is often overlooked. Due to the scarcity of reports related to this disorder, we conducted a systematic review of the literature related to infrapatellar fat pad impingement in evaluating the following: (1) clinical presentation, (2) imaging, (3) management, and (4) clinical outcomes. A systematic review was conducted investigating all available primary literature related to the clinical presentation, imaging, management, and outcomes of infrapatellar fat pad impingement syndrome. A total of 15 studies (9 case reports, 1 case series, and 5 retrospective studies) comprising 167 patients met eligibility criteria for this review. Patients with infrapatellar fat pad impingement were found to most often present with anterior knee pain that worsened with activity, and was frequently associated with trauma. Anterior knee pain, tenderness to palpation over the patellar tendon, loss in terminal extension, and pain with direct pressure on the medial or lateral side of the patella with the knee extended was often found on examination. Although patients may have classic imaging findings on magnetic resonance imaging (localized edema of the infrapatellar fat pad, deep fluid-filled infrapatellar bursa, nonvisualization of clefts, fibrosis, and calcifications), not all patients had positive imaging findings, thus making infrapatellar fat pad impingement a clinical diagnosis. Treatment begins with nonoperative management, but in recalcitrant cases, patients can be surgically treated with arthroscopic fat pad resection. Most patients who undergo operative treatment report improvement or complete resolution of symptoms in terms of pain and range of motion, and are able to return to work. To the best of our knowledge, this is the first comprehensive review on infrapatellar fat pad impingement to better aid the orthopaedic surgeons in diagnosing, treating, and managing patient expectations for this often overlooked knee pathology.

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“…A PRISMA flowchart was created for transparency of report selection (►Fig. 3). A total of 395 reports were identified.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Infrapatellar Fat Pad Impingement: A Systematic Review

et al. 2017

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“…The impact of this tissue can be measured basing on activity of the infrapatellar fat pad inside the knee joint, which as the rest of the fat tissue in the organism synthesizes proinflammatory cytokines, adipokines and growth factors. Infrapatellar fat pad produces the P substance, which irritates the nociceptive fibers causing pain to appear [15,17].…”

Section: Fat Tissue and It Is Impact On The Organismmentioning

confidence: 99%

Fat Tissue and Synthesized by Her Adipokines as Markers Indicating the Development and Progress of Osteoarthritis

et al. 2020

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Arthrosis as osteoarthritis is a global problem that affects more and more people and is associated with severe chronic pain, reduced mobility and, consequently, disability. The etiology of degenerative disease is complex and depends on many factors. However, its course was not fully understood. One of the factors affecting the development of arthrosis is obesity. Obesity is a growing problem. Over the past 30 years, the number of overweight people has almost doubled. In people suffering from obesity, whose body mass index is above 30kg/m2, the risk of developing degenerative changes in articular cartilage is six times higher than the risk of developing this disease in people with normal body weight. Osteoarthritis is detected when the symptoms get worse where the changes are already at some stage. Therefore, a lot of research is currently underway to find suitable biomarkers, which would indicate the potential development of degenerative changes in the future and at the same time the possibility of inhibiting their activity. One of them may be adipokines, which are synthesized by adipose tissue and affect cartilage. In obese people, adipokines may contribute to the inflammation of the low charterer, which accompanies both obesity and arthrosis. These compounds can be specific biomarkers to assess the degree of progression and severity of osteoarthritis. The aim: To assess the importance of obesity and adipokines produced by adipose tissue as specific markers of arthrosis.

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“…For example, Skalska et al [74] found a similar expression of surface phenotypes of IPFSCs from both RA and OA patients and a comparable effect of chondrogenic induction that was decreased by supplementation of TNF in the medium. Wei et al [83] demonstrated that conditioned medium from the IPFP of OA and traumatically injured joints inhibited the chondrogenesis of BMSCs by decreasing type II collagen and aggrecan expression. They also found that conditioned medium from IPFP-derived macrophages decreased the expression of hyaline cartilage genes, suggesting that resident macrophages may be responsible for deterioration in MSC-based cartilage repair [84].…”

Section: Inflammationmentioning

confidence: 99%

Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine

2018

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Growing evidence indicates that infrapatellar fat pad (IPFP)-derived stem cells (IPFSCs) exert robust proliferation capacities and multilineage differentiation potentials. However, few papers summarize the advantages that the IPFP and IPFSCs have in regenerative medicine. In this review we delineate the development and anatomy of the IPFP by comparing it with an adjacent fibrous tissue, synovium, and a more frequently harvested fat depot, subcutaneous adipose tissue. Furthermore, we explore the similarities and differences of stem cells from these three tissues in terms of IPFSCs, synovium-derived stem cells and subcutaneous adipose tissue-derived stem cells in proliferation capacity and tri-lineage differentiation potentials, including chondrogenesis, osteogenesis and adipogenesis. Finally, we highlight the advantages of IPFSCs in regenerative medicine, such as the abundant accessibility and the ability to resist inflammation and senescence, two hurdles for cell-based tissue regeneration. Considering the comparative advantages of IPFSCs, the IPFP can serve as an excellent stem cell source for regenerative medicine, particularly for cartilage regeneration.

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The infrapatellar fat pad from diseased joints inhibits chondrogenesis of mesenchymal stem cells

Cited by 17 publications

References 14 publications

Infrapatellar Fat Pad Impingement: A Systematic Review

Infrapatellar Fat Pad Impingement: A Systematic Review

Fat Tissue and Synthesized by Her Adipokines as Markers Indicating the Development and Progress of Osteoarthritis

Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine

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