The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

Klein-Wieringa, I.R.; Kloppenburg, Margreet; Bastiaansen-Jenniskens, Y.M.; Yusuf, Erlangga; Kwekkeboom, Joanneke C; El-Bannoudi, H.; Nelissen, Rob G H H; Zuurmond, Anne‐Marie; Stojanovic-Susulic, V.; Osch, Gerjo J.V.M. van; Toes, René E. M.; Ioan‐Facsinay, Andreea

doi:10.1136/ard.2010.140046

Cited by 236 publications

(270 citation statements)

References 31 publications

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“…24 We have previously demonstrated that functional cartilage tissue can be engineered using immature porcine FPSCs 32,33,35 ; however, it remains unclear whether such grafts can be engineered using stem cells isolated from human osteoarthritic IFP tissue. The IFP of patients with OA has been shown to have an inflammatory phenotype, 50 which may impact the ability of stem cells isolated from this tissue to generate a functional cartilaginous tissue. The objective of this study was to first compare chondrogenesis of FPSCs in pellet culture to that in agarose hydrogels that are commonly used to engineer functional cartilaginous grafts.…”

Section: Introductionmentioning

confidence: 99%

The Role of Environmental Factors in Regulating the Development of Cartilaginous Grafts Engineered Using Osteoarthritic Human Infrapatellar Fat Pad–Derived Stem Cells

Liu

Buckley

Downey

et al. 2012

Tissue Engineering Part A

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Section: Introductionmentioning

confidence: 99%

The Role of Environmental Factors in Regulating the Development of Cartilaginous Grafts Engineered Using Osteoarthritic Human Infrapatellar Fat Pad–Derived Stem Cells

Liu

Buckley

Downey

et al. 2012

Tissue Engineering Part A

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“…The knee joint is the only joint in which there is localized adipose tissue, recognized also as being metabolically active [20][21][22][23]25], and the joint most often affected by OA. While previous…”

Section: Discussionmentioning

confidence: 99%

“…To date, only two studies have compared adipokine expression of the IFP to a reference sample of SAT adipose tissue. However, these studies were limited to individuals with endstage OA only [21,22]. The authors reported a significant increase in the protein levels of IL-6, soluble IL-6 receptor, and leptin in the IFP relative to SAT.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the knee likely provides an ideal setting in which to examine any potential role(s) of fat on OA development/progression, particularly as it is the only joint to contain a large intra-articular deposit of adipose tissue. The infrapatellar fat pad (IFP) is an intracapsular and extrasynovial structure, distinguishable from SAT and VAT by its unique location and relative size [19][20][21][22][23][24]. …”

mentioning

confidence: 99%

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Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

Weston¹

2015

J Arthritis

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IntroductionThere is now compelling evidence that adipose tissue is metabolically active and that adipose derived metabolic factors can have physiological effects [1,2]. In adults, fat exists primarily as white adipose tissue. This tissue is widely distributed throughout the body with the two most prevalent forms being subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).SAT accounts for the vast majority of all the fat in the body [3,4] and potentially is a major source of adipose derived factors in the systemic circulation [5]. Each type of adipose tissue displays unique phenotypic and genotypic characteristics [6]. Some have suggested that each fat type may have differing developmental lineages that play a role in body fat distribution, obesity and the variety of functional properties of various adipose tissue sites in the body [7]. Previous work has shown that inflammatory hormones secreted by adipocytes and macrophages can significantly affect expression levels of leptin, adiponectin, tumour necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in SAT [1,[8][9][10]. The systemic release of these adipose-derived hormones is thought to be responsible for the low-grade inflammatory state commonly observed in obese individuals [6,11,12].The link between obesity and osteoarthritis (OA) has long been established [13]. This link is in part believed to be a metabolic one [13], in addition to the recognized impact of increasing mechanical forces on weight-bearing joints [12]. Many individuals experience OA symptoms in non-weight bearing joints as well [14][15][16]. Indeed, studies are revealing associations between levels of adipose-derived factors in blood and/or synovial fluid and the presence or severity of osteoarthritis, particularly the knee [17,18].Osteoarthritis is most prevalent in the knee [15], and association between OA and obesity has been particularly marked for this joint [16]. Thus, the knee likely provides an ideal setting in which to examine any potential role(s) of fat on OA development/progression, particularly as it is the only joint to contain a large intra-articular deposit of adipose tissue. The infrapatellar fat pad (IFP) is an intracapsular and extrasynovial structure, distinguishable from SAT and VAT by its unique location and relative size [19][20][21][22][23][24]. AbstractObjective: Previous research has examined gene expression of the IFP from individuals with early and endstage knee OA. However, there is little understanding of whether the differential expression that was found is a local effect associated with OA disease severity. The objective of this study was to compare gene expression of the SAT and IFP both within individuals with early and late stage knee OA.Methods: Knee SAT and corresponding IFP samples were harvested from twenty-nine patients with endstage and five patients with early stage OA at the time of knee surgery. Total RNA was then extracted, labelled and hybridized to Illumina whole genome expression arrays. Arrays were scanned and intensity of hybridi...

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“…48,49 In addition, the synovial fat tissue or fat pad is also suggested to contribute to the disease processes with the production of cytokines and adipokines. 50 These data highlight the potential contribution of inflammation not only to signs and symptoms but also to the pathological processes. Whether antiinflammatory drugs should therefore be preferred over conventional pain killers remains an open question that is often debated.…”

Section: The Articular Cartilage and The Underlying Bone: A Functionamentioning

confidence: 99%

Osteoarthritis, a disease bridging development and regeneration

Lories

Luyten²

2012

BoneKEy Reports

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The osteoarthritic diseases are common disorders characterized by progressive destruction of the articular cartilage in the joints, and associated with remodeling of the subchondral bone, synovitis and the formation of bone outgrowths at the joint margins, osteophytes. From the clinical perspective, osteoarthritis leads to joint pain and loss of function. Osteoarthritis is the leading cause of progressive disability. New data from genetic, translational and basic research have demonstrated that pathways with essential roles in joint and bone development also contribute to the postnatal homeostasis of the articular cartilage and are involved in osteoarthritis, making these potential therapeutic targets. Other systems of interest are the tissue-destructive enzymes that break down the extracellular matrix of the cartilage as well as mediators of inflammation that contribute to synovitis. However, the perspective of a durable treatment over years to decades highlights the need for a personalized medicine approach encompassing a global view on the disease and its management, thereby including nonpharmaceutical approaches such as physiotherapy and advanced surgical methods. Integration of novel strategies based on their efficacy and safety with the identification of individuals at risk and optimal individual rehabilitation management remains a major challenge for the medical community in particular, as the incidence of osteoarthritis is likely to further increase with the overall aging of the population.

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The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

Abstract: There are profound differences in secreted inflammatory factors and immune cell composition between the IFP and ScAT. These data indicate that IFP-derived soluble mediators could contribute to pathophysiological processes in the OA knee joint.

Cited by 236 publications

References 31 publications

The Role of Environmental Factors in Regulating the Development of Cartilaginous Grafts Engineered Using Osteoarthritic Human Infrapatellar Fat Pad–Derived Stem Cells

The Role of Environmental Factors in Regulating the Development of Cartilaginous Grafts Engineered Using Osteoarthritic Human Infrapatellar Fat Pad–Derived Stem Cells

Gene Expression Profiles of the Subcutaneous Fat and Infrapatellar Fatpad in Individuals with Early and Endstage Knee Osteoarthritis: A Cross-sectional Analysis

Osteoarthritis, a disease bridging development and regeneration

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