The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain

Hosseini, Marjan; Parviz, Mohsen; Shabanzadeh, Alireza P.; Mohseni‐Moghaddam, Parvaneh; Gholami, Leila; Mehrabadi, Shima

doi:10.1080/01616412.2020.1747730

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Furthermore, the researchers identified eight subtypes of glutamate metabotropic receptors (mGluR1-8) in PAG exert different effects on nociception modulation, of which hyperalgesia was elicited by activating mGluR1 and mGluR5 (Group I), while activation of mGluR2, mGluR3 (Group II), and mGluR4, 6, 7, 8 (Group III) led to analgesia. Studies conducted by Hosseini et al (2020) showed that after administration of mGluR8 agonists (S)-3,4dicarboxyphenylglycine (DCPG) in PAG, glutamate transmission increased, then RVM ON cell firings were reduced and OFF cell activities were enhanced, and predominantly generated antinociceptive effects. However, Marabese et al (2007) reported a disturbing finding in which intra-PAG microinjection of AMN082, a selective mGluR7 agonist, increased RVM ON cell activity while abrogating OFF cell activity and then induced hyperalgesia.…”

Section: Neurotransmitters Mediating Pag-driven Descending Modulation...mentioning

confidence: 99%

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Neurotransmitters Mediating Pag-driven Descending Modulation...mentioning

confidence: 99%

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

2024

Frontiers Research Topics

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“…Furthermore, the researchers identified eight subtypes of glutamate metabotropic receptors (mGluR1-8) in PAG exert different effects on nociception modulation, of which hyperalgesia was elicited by activating mGluR1 and mGluR5 (Group I), while activation of mGluR2, mGluR3 (Group II), and mGluR4, 6, 7, 8 (Group III) led to analgesia. Studies conducted by Hosseini et al (2020) showed that after administration of mGluR8 agonists (S)-3,4-dicarboxyphenylglycine (DCPG) in PAG, glutamate transmission increased, then RVM ON cell firings were reduced and OFF cell activities were enhanced, and predominantly generated antinociceptive effects. However, Marabese et al (2007) reported a disturbing finding in which intra-PAG microinjection of AMN082, a selective mGluR7 agonist, increased RVM ON cell activity while abrogating OFF cell activity and then induced hyperalgesia.…”

Section: Neural Circuits and Neurotransmitters Modulating Rvm On And ...mentioning

confidence: 99%

Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters

et al. 2023

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The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain modulation system, and directly affects spinal nociceptive transmission through pronociceptive ON cells and antinociceptive OFF cells in this area. The functional status of ON and OFF neurons play a pivotal role in pain chronification. As distinct pain modulative information converges in the RVM and affects ON and OFF cell excitability, neural circuits and transmitters correlated to RVM need to be defined for an in-depth understanding of central-mediated pain sensitivity. In this review, neural circuits including the role of the periaqueductal gray, locus coeruleus, parabrachial complex, hypothalamus, amygdala input to the RVM, and RVM output to the spinal dorsal horn are discussed. Meanwhile, the role of neurotransmitters is concluded, including serotonin, opioids, amino acids, cannabinoids, TRPV1, substance P and cholecystokinin, and their dynamic impact on both ON and OFF cell activities in modulating pain transmission. Via clarifying potential specific receptors of ON and OFF cells, more targeted therapies can be raised to generate pain relief for patients who suffer from chronic pain.

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“…The PAG starts the endogenous pain modulatory system and is densely projected to the RVM. The vlPAG sends glutamatergic (Gluergic) projections to the RVM, and persistent activation of metabotropic glutamate (GLu) receptors in the PAG can increase pain thresholds and suppress chronic NP by modulating the activity of RVM OFF cells ( Chung et al, 2020 ; Hosseini et al, 2020 ). Eliminating the projection from vlPAG to RVM can lead to the generation of NP ( Huang J. et al, 2019 ).…”

Section: Np-related Brain Nuclei and Neural Circuitsmentioning

confidence: 99%

Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research

Su,

Cai,

Dou

et al. 2023

Front. Neurosci.

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Neuropathic pain (NP) is known to be associated with abnormal changes in specific brain regions, but the complex neural network behind it is vast and complex and lacks a systematic summary. With the help of various animal models of NP, a literature search on NP brain regions and circuits revealed that the related brain nuclei included the periaqueductal gray (PAG), lateral habenula (LHb), medial prefrontal cortex (mPFC), and anterior cingulate cortex (ACC); the related brain circuits included the PAG-LHb and mPFC-ACC. Moreover, acupuncture and injurious information can affect different brain regions and influence brain functions via multiple aspects to play an analgesic role and improve synaptic plasticity by regulating the morphology and structure of brain synapses and the expression of synapse-related proteins; maintain the balance of excitatory and inhibitory neurons by regulating the secretion of glutamate, γ-aminobutyric acid, 5-hydroxytryptamine, and other neurotransmitters and receptors in the brain tissues; inhibit the overactivation of glial cells and reduce the release of pro-inflammatory mediators such as interleukins to reduce neuroinflammation in brain regions; maintain homeostasis of glucose metabolism and regulate the metabolic connections in the brain; and play a role in analgesia through the mediation of signaling pathways and signal transduction molecules. These factors help to deepen the understanding of NP brain circuits and the brain mechanisms of acupuncture analgesia.

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The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain

Cited by 7 publications

References 24 publications

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric

Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters

Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research

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