The Inhibition of Experimental Nephrocalcinosis with A Prostaglandin Synthetase Inhibitor

Buck, A. C.

doi:10.1007/978-1-4684-7272-1_123

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…From the results of their studies, Buck et al [16][17][18][19] and Ito et al 20 suggested that the incorporation of EPA in the diet could be a unique way of correcting hypercalciuria. We carried out a clinical study with the use of EPA-E in a highly purified form, with the purpose of determining its effect on urine chemistries in people who form calcium-containing stones.…”

Section: Introductionmentioning

confidence: 99%

Effect of ethyl icosapentate on urinary calcium and oxalate excretion

et al. 2000

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Background: The effect of ethyl icosapentate (EPA-E) on urinary calcium and oxalic acid excretion was examined to evaluate whether EPA-E is useful in the prevention of calciumcontaining urinary stones. Methods: For 6 months, urine was measured daily from 40 calcium-containing urinary stone producers at an outpatient clinic, before and after the administration of 1800 mg/day EPA-E. The urine was measured for volume, urea nitrogen, creatinine, calcium, magnesium, phosphorus, uric acid, oxalic acid and citric acid. Serum total cholesterol and triglyceride were also measured. Results: Urinary calcium excretion was not reduced in any of the patients or particular hypercalciuric groups, nor did the level of calcium change. However, nine of the 25 hypercalciuric patients experienced a significant urinary calcium reduction to the normal calciuric level (a reduction of approximately 44%). It is not known why these particular patients experienced a reduction. Urinary oxalic acid did not change, whether hypercalciuria was present or not. Conclusions: These findings suggest that EPA-E is not particularly effective in reducing urinary calcium excretion in the hypercalciuric patients, but it needs future investigation because some patients experienced significant urinary calcium reduction.

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Section: Introductionmentioning

confidence: 99%

Effect of ethyl icosapentate on urinary calcium and oxalate excretion

et al. 2000

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“…It has been sug gested that prostaglandin (PG) plays a role in regulating urinary calcium excretion [4,5]. Buck et al proposed that the initiating factor for stone formation may be PG syn thesis, leading to hypercalciuria [6,7], In an animal exper iment, Buck et al [8] prevented nephrocalcinosis and hypercalciuria produced by the intraperitoneal injection of 10% calcium gluconate by feeding fish oil. Although hypercalciuria of the rats used in the experiment was induced by the injection of calcium rather than one of the aforementioned mechanisms, it is noteworthy that fish oil administration prevented the abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ethyl Icosapentate on Urinary Calcium Excretion in Calcium Oxalate Stone Formers

Itô

Kotake²,

Nomura³

1995

Urol Int

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Buck and co-workers presented the hypothesis that the initiating factor of stone formation triggers the mechanisms for prostaglandin synthesis, resulting in the biochemical abnormalities associated with stone disease. In order to test this hypothesis, we undertook a clinical study with the use of a highly purified preparation of ethyl icosapentate. Ethyl icosapentate (1,800 mg/day) was administered to 57 patients with urinary stones chiefly composed of calcium oxalate for 6 weeks. Urinary calcium in the hypercalciuric patients reduced significantly, but the calcium level in the normocalciuric group did not decrease. Oxalate values did not reduce either in the hypercalciuric patients or in the normocalciuric subjects. No serious side effects were observed.

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The Inhibition of Experimental Nephrocalcinosis with A Prostaglandin Synthetase Inhibitor

Cited by 2 publications

References 11 publications

Effect of ethyl icosapentate on urinary calcium and oxalate excretion

Effect of ethyl icosapentate on urinary calcium and oxalate excretion

Effect of Ethyl Icosapentate on Urinary Calcium Excretion in Calcium Oxalate Stone Formers

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