The Inhibition of Foam Cell Formation by Sodium Diethyldithiocarbamate

Schultz, Donna; Skamarauskas, John T.; N, Law; Mitchinson, M. J.; Hunt, James V.

doi:10.3109/10715769509064039

Cited by 5 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DETC not only effectively inhibits lipoprotein uptake and foam cell formation in cultures of macrophage-like cells [48] but also conveys antiproliferative activity on various cell types [50], most likely by the induction of apoptosis [10] and inhibition of NF-κB [57]. Furthermore, TETD/DETC represses a number of enzymes such as tubulin by complexation with metal cations or reaction with functional sulfhydryl groups, causing the destruction of the microtubuli [26,29].…”

Section: Drug Release In Relation To the Kind Of The Polymermentioning

confidence: 99%

Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications

Sternberg

Petersen

Grabow

et al. 2013

Biomedizinische Technik/Biomedical Engineering

View full text Add to dashboard Cite

Implants providing controlled, local release of active substances are of interest in different medical applications. Therefore, the focus of the present article is the development of implant-associated diffusion- or chemically controlled local drug delivery (LDD) systems based on biodegradable polymeric drug carriers. In this context, we provide new data and review our own recently published data concerning the drug release behavior of diffusion-controlled LDD systems in relation to the kind of polymer, drug content, coating mass/thickness, and layer composition. We demonstrate that polymers allow a wide range of control over the drug release characteristics. In this regard, we show that the glass transition temperature of a polymer has an impact on its drug release. Additionally, the blending of hydrophobic, semicrystalline polymers with amorphous polymers leads to an increase in the rate of drug release compared with the pure semicrystalline polymer. Moreover, the percentage loading of the embedded drug has a considerable effect on the rate and duration of drug release. Furthermore, we discuss chemically controlled LDD systems designed for the release of biomolecules, such as growth factors, as well as nanoparticle-mediated LDD systems. With our own published data on drug-eluting stents, microstents, and cochlear implants, we highlight exemplary implant-associated LDD systems designed to improve implant performance through the reduction of undesirable effects such as in-stent restenosis and fibrosis.

show abstract