The inhibition of Helicobacter pylori infected cells by Origanum minutiflorum

Özen, Fatma; Ekinci, Fatma Yeşim; Korachi, May

doi:10.1016/j.indcrop.2014.04.037

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…It was followed by p-cymene (11.80) similarly to our results 33. Carvacrol (29.22%) was observed as the predominant compound of O. minutiflorum which collected from Isparta and it displayed antibacterial activity against Helicobacter pylori in/on infected cells 18. The major compound of the O. minutiflorum essential oil was found as carvacrol (90.78-92.95%) and essential oil showed high antimicrobial effect against S. aureus, S. faecalis, B. subtilis, E. coli, and two fungi (C. albicans, C. tropicalis).…”

supporting

confidence: 84%

“…In Anatolia, it is used as a spice for seasoning, as herbal tea and also as a medicinal herb for curing stomach-aches and respiratory colds. 18 This work was conducted to (i) determine the main constituents of the volatile oil of Origanum minutiflorum O. Schwarz and P. H. Davis (Lamiaceae) collected from wild populations in Antalya, Turkey; (ii) examine the antioxidant activity of methanol extract with vary methods: Phosphomolybdenum, 2,2-diphenyl-1-picrylhydrazyl radical scavenging (DPPH), hydrogen peroxide scavenging, β-carotene bleaching activity, ferric-ion reducing power (FRAP), reducing power and cupric ions (Cu 2+ ) reducing antioxidant capacity (CUPRAC) methods; (iii) determine the antimicrobial activity against 15 microorganisms.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Contents and Biological Activity of Endemic Origanum minutiflorum Grown in Turkey

Albayrak¹,

Aksoy²

2019

IJPER

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Objective: In this study, biological property of Origanum minutiflorum O. Schwarz and P. H. Davis (Lamiaceae) was evaluated. Methods: The total phenolic and flavonoid amount were detected using Folin-Ciocalteu and aluminum chloride colorimetric assays. The antioxidant activity was assayed with phosphomolybdenum, 2,2-diphenyl-1picrylhydrazyl radical scavenging (DPPH), hydrogen peroxide scavenging, β-carotene bleaching activity, ferric-ion reducing power (FRAP), reducing power and cupric ions (Cu 2+) reducing antioxidant capacity (CUPRAC) methods. Antimicrobial activities of the extract and the essential oil were studied by broth microdilution and agar well-diffusion assays using 12 bacteria, 1 yeast and 2 fungi. Results: Twenty nine components were identified by gas chromatography/mass spectrometry (GC/MS), representing 100% of the oil. The main component of O. minutiflorum oil was carvacrol (90.87%). O. minutiflorum extract exhibited strong DPPH scavenging activity (IC 50 = 13.68 μg/ml). In addition, O. minutiflorum had an effective hydrogen peroxide scavenging and ferric ions (Fe 3+) reducing activities. The extract and essential oil had strong antibacterial effects against all bacteria tested. The methanol extract had no activity against yeast and two fungi tested, but essential oil exhibited prominent antifungal activity. Conclusion: O. minutiflorum extract and essential oil might be alternative agents in vary industries such as food, pharmacy and health.

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supporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Phenolic Contents and Biological Activity of Endemic Origanum minutiflorum Grown in Turkey

Albayrak¹,

Aksoy²

2019

IJPER

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“…Thus, the further search for the most efficient essential oil based formulation against H . pylori is justified (Bergonzelli et al ., ; Deriu et al ., ; Eftekhar et al ., ; Esmaeili et al ., ; Falsafi et al ., ; Ohno et al ., ; Ozen et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…However, there are numerous reports on anti-H. pylori activity of various essential oils. Thus, the further search for the most efficient essential oil based formulation against H. pylori is justified (Bergonzelli et al, 2003;Deriu et al, 2007;Eftekhar et al, 2009;Esmaeili et al, 2012;Falsafi et al, 2015;Ohno et al, 2003;Ozen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Binary and Tertiary Mixtures of Satureja hortensis and Origanum vulgare Essential Oils as Potent Antimicrobial Agents Against Helicobacter pylori

Lesjak

Simin

Orčić

et al. 2015

Phytotherapy Research

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Essential oils possess strong antimicrobial activity, even against multiresistant Helicobacter pylori. Available therapies against H. pylori infection have multiple disadvantages, indicating a great need for a development of new therapeutics. The purpose of this study was to develop a potent natural product based anti-H. pylori formulation. First, anti-H. pylori activity of nine essential oils was determined, after which the most active oils were mixed in various ratios for further testing. Satureja hortensis, Origanum vulgare subsp. vulgare and O. vulgare subsp. hirtum essential oils expressed the highest activity (MIC = 2 μL mL(-1)). Their binary and ternary mixtures exhibited notably higher antimicrobial activity (MIC ≤ 2 μL mL(-1)). The most active was the mixture of S. hortensis and O. vulgare subsp. hirtum oils in volume ratio 2:1, which expressed 4 times higher activity than individual oils (MIC = 0.5 μL mL(-1)). According to GC-MS, both oils in the mixture were characterized by high content of phenols (48-73%), with carvacrol as the main carrier of antimicrobial activity. Presented in vitro study pointed out binary mixture of S. hortensis and O. vulgare subsp. hirtum essential oils in volume ratio 2:1 as promising candidate for further in vivo studies targeting H. pylori infection.

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“…It is used as a spice for seasoning, as a herbal tea, and also as a medicinal herb for curing stomach-aches and respiratory colds. [23] Natural products have been the source of many pharmaceutically and medicinally active compounds. [24][25][26][27][28] Origanum genus consists of forty three species and eighteen hybrids, sixteen of which are endemic for Turkey.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

Elmastaş

Celik

Genç

et al. 2018

International Journal of Food Properties

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Origanum species are significant aromatic and medicinal plants used in food and pharmaceutical industries. Isolation of bioactive compounds was executed on n-butanol extract to yield the compounds responsible for the activities. Tricosan-1-ol (1), (8E,16E)-tetracosa-8,16-diene-1,24-diol (2), azepan-2-one (3), 3,4-dihydroxybenzoic acid (4), apigenin (5), eriodictyol (6), globoidnan-A (7), luteolin (8), rosmarinic acid (9), apigenin-7-O-glucuronide (10), and vicenin-2 (11) were isolated by chromatographic methods (column chromatography and semi-preparative High Performance Liquid Chromatography (HPLC) and structures were elucidated on the basis of spectroscopic techniques including 1D/2D nuclear magnetic resonance (NMR) and Liquid chromatography/Time-of-flight/Mass spectrometry (LC-TOF/MS). The isolated compounds and extracts were applied for antioxidant assays including 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS •+ ) scavenging, reducing power, and cuprac techniques. 3,4-Dihydroxy benzoic acid (4), eriodictyol (6), luteolin (8), and rosmarinic acid (9) revealed the considerable antioxidant activities. ARTICLE HISTORY

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The inhibition of Helicobacter pylori infected cells by Origanum minutiflorum

Cited by 14 publications

References 30 publications

Phenolic Contents and Biological Activity of Endemic Origanum minutiflorum Grown in Turkey

Phenolic Contents and Biological Activity of Endemic Origanum minutiflorum Grown in Turkey

Binary and Tertiary Mixtures of Satureja hortensis and Origanum vulgare Essential Oils as Potent Antimicrobial Agents Against Helicobacter pylori

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

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