The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43

Lin, Hui-Chen; Yang, Chih‐Jen; Kuan, Yu‐Hsiang; Wang, Wei-Kuang; Chang, Wen‐Wei; Lee, Che‐Hsin

doi:10.7150/ijms.20661

Cited by 30 publications

(26 citation statements)

References 44 publications

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“…To put up with this immune evasion, host immune cells recognize and kill tumor cells by an effective agent. Tumor expressed IDO has been observed in different tumors including melanoma, breast cancer, and colon cancer 3 . This study aims to identify that EPA as an immunotherapy agent discouraged tumor IDO further diffusion.…”

Section: Discussionmentioning

confidence: 99%

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Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

Wang

Yang

et al. 2018

Int. J. Med. Sci.

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Marine plants and animals have omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is required for biological processes, but humans are unable to synthesize them and must be obtained from dietary sources. EPA has been used as an antitumor agent but the molecular mechanisms for the regulation of tumor microenvironment immunity by EPA are still unknown. The indoleamine 2,3-dioxygenase 1 (IDO) catalyzes conversion of tryptophan to kynurenine to induce immune evasion in tumor microenvironment. In this study, EPA inhibited the expression of IDO via downregulation of protein kinase B (Akt)/mammalian targets of rapamycin (mTOR) signaling pathway in tumor cells. Meanwhile, a significant decrease in kynurenine levels and increase in T cell survival were observed after tumor cells treated with EPA. The results demonstrated that EPA can activate host antitumor immunity by inhibiting tumor IDO expression. Therefore, our finding suggests that EPA can be enormous potential for cancer immunotherapy.

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Section: Discussionmentioning

confidence: 99%

“…IDO can promote tumor immune escape. IDO expression was found in tumor cells including melanoma and breast cancer 3 .…”

Section: Introductionmentioning

confidence: 99%

Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

Wang

Yang

et al. 2018

Int. J. Med. Sci.

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“…Rabbit anti-mouse IgG-peroxidase antibody (Sigma Aldrich) and goat anti-rabbit IgG-peroxidase antibody (Sigma Aldrich) were used as the secondary antibody and protein-antibody complexes were visualized by enhanced chemiluminescence system. The Western blotting signals were quantified with ImageJ software (rsbweb.nih.gov/ij/) 14 , 15 .…”

Section: Methodsmentioning

confidence: 99%

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation

et al. 2018

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Chemotherapy is one of effective methods for the treatment of tumor. Patients often develop drug resistance after chemotherapic cycles. Salmonella has potential as antitumor agent. Salmonella used in tandem with chemotherapy had additive effects, providing a rationale for using tumor-targeting Salmonella in combination with conventional chemotherapy. To improve the efficacy and safety of Salmonella, a further understanding of Salmonella interactions with the tumor microenvironment is required. The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is highly relevant for the success of chemotherapy. Following Salmonella infection, dose-dependent downregulation of P-gp expressions were examined. Salmonella significantly decreased the efflux capabilities of P-gp, as based on the influx of Rhodamine 123 assay. In addition, Salmonella significant reduced the protein express the expression levels of phosph-protein kinase B (P-AKT), phosph-mammalian targets of rapamycin (P-mTOR), and phosph-p70 ribosomal s6 kinase (P-p70s6K) in tumor cells. The Salmonella-induced downregulation of P-gp was rescued by transfection of cells with active P-AKT. Our results demonstrate that Salmonella in tumor sites leads to decrease the expression of P-gp and enhances the combination of Salmonella and 5-Fluorouracil therapeutic effects.

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“…Application of genetic algorithms to parameter identification is a relatively new endeavour, especially when addressing mechanical constitutive modelling. Identification of composite, organic tissue, viscoelastic, viscoplastic, elastic‐plastic and damage parameters illustrate application of genetic algorithms to this class of problems .…”

Section: Parameter Identification and Optimization Strategiesmentioning

confidence: 99%

Identification of constitutive parameters – optimization strategies and applications

Vaz

Cardoso

Muñoz-Rojas

et al. 2015

Materialwissenschaft Werkst

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The pursuit to reduce manufacturing costs and increase product quality has led industries to use commercial codes and appropriate material models to simulate a wide range of metal forming operations. This scenario has prompted a healthy discussion on the strategies to obtaining constitutive parameters able to yield accurate numerical predictions. Optimization‐based parameter identification techniques have opened completely new routes to determine material parameters for this class of forming problems. Notwithstanding, the most appropriate optimization strategy (or development of new ones) for the trinomial forming operation – constitutive model – constitutive parameters is still open to debate. This work highlights the important role that optimization strategies play to determine parameters of constitutive models. A brief description of gradient‐based, gradient‐free and hybrid optimization approaches is presented within the framework of parameter identification. Comparative studies and applications to classical and damaged material models are also discussed.

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The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43

Cited by 30 publications

References 44 publications

Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation

Identification of constitutive parameters – optimization strategies and applications

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