The inhibition of Mpro, the primary protease of COVID-19, byPoria cocosand its active compounds: a network pharmacology and molecular docking study

Abstract

The inhibition of Mpro, the primary protease of COVID-19, by Poria cocos.

Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry

“…The results indicated that the analytical performance and sensitivity were comparable with conventional HPLC and HPLC-MS methods. 5,6 The detailed information is summarized in Table 1. In addition, as depicted in Table S3,† the testing stability was carried out, and the results showed good stability (RSD% < 5%).…”

“…These parts have respective pharmacological functions. Poria cocos , also referred to as white Poria (WP, Baifuling), has numerous properties for treating tumors, 3 inflammation, 4 viral diseases, 5 etc. The epidermal part of Poria cocos , known as Poriae cutis (PC, Fulingpi), specializes in diuresis and detumescence.…”

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

“…PA has been further observed to decrease blood glucose levels in streptozocin-treated mice by enhancing insulin sensitivity irrespective of peroxisome proliferator-activated receptor-γ (69). I, PA displays inhibitory effects on the SARS-CoV-2 3CL hydrolytic enzyme in vitro, with an IC 50 value of 18.607 µM (12). Akihisa et al (17) demonstrated that PA exhibits antiviral activity against Epstein-Barr virus early antigen-induced TPA in Raji cells, with an IC 50 value of 286 mol ratio/32 pmol TPA.…”

“…As presented in Table I , PA displays inhibitory effects on the SARS-CoV-2 3CL hydrolytic enzyme in vitro , with an IC 50 value of 18.607 µ M ( 12 ). Akihisa et al ( 17 ) demonstrated that PA exhibits antiviral activity against Epstein-Barr virus early antigen-induced TPA in Raji cells, with an IC 50 value of 286 mol ratio/32 pmol TPA.…”

“…Overall, >160 terpenoids have been identified in Poria cocos ( 8 ). As an important bioactive terpenoid, PA has been reported to exhibit numerous pharmacological effects, such as cytotoxic ( 9 ), anti-inflammatory ( 10 ), antihyperglycemic ( 11 ), antibacterial and antiviral ( 12 ), sedative-hypnotic ( 13 ) and anti-ischemia/reperfusion ( 14 ) effects. Thus, PA has potential for the treatment of various diseases.…”