The Inhibitor of DNA Binding Family Regulates the Prognosis of Ovarian Cancer

Abstract

Background: The inhibitor of DNA binding or differentiation (ID) protein family contributes to the carcinogenesis and progression of various cancers. However, its mechanistic role in tumor initiation and progression of ovarian cancer (OC) has remained unclear. Methods: We used the Oncomine, GEPIA, Kaplan-Meier plotter, cBioPortal, SurvExpress, PROGgene V2 server, TIMERdatabase, and FunRich to evaluate the expression and predictive prognostic value of individual IDs members’ mRNA in patients with OC. Results: Our results revealed that the mRNA transcripts of all ID family members were markedly downregulated in OC compared to normal tissue. Aberrant expression of ID 1/3/4correlated with cancer aggressiveness and clinical in OC patients. The prognostic value of ID members was also explored within the subtypes, pathological stages, clinical stages, and TP53 mutational status. The group with a low risk IDs showed a relatively good overall survival (OS) in comparison to the high-risk group. In contrast, the expression level of IDs was significantly associated with the levels of infiltrating B cells and macrophages. Finally, enrichment analysis showed that ID co-expressed genes were involved in ID-, c-MYC, TNF-, and Wnt signaling pathways. Conclusion: These results indicate that ID1/3/4 may be exploited as promising prognostic biomarkers and therapeutic targets in OC patients.