The Inhibitory Activity of Natural Products to Xanthine Oxidase

Zhou, Shiyang; Huang, Gangliang

doi:10.1002/cbdv.202300005

Cited by 9 publications

(2 citation statements)

References 123 publications

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“…Concomitant use of TCM for HU is gaining traction due to its ability to impact various signaling pathways and UA transporters, thus promoting balanced inflammatory interactions and UA excretion [41]. Natural products containing flavonoids, terpenoids, alkaloids, and other compounds show promise as URAT1 or XO inhibitors [42,43]. Phytochemicals derived from natural sources possess the beneficial property of downregulating UA levels and dissolving monosodium urate crystals [44].…”

Section: Treatment Strategiesmentioning

confidence: 99%

Hyperuricemia: Current State and Prospects

Zhang

2024

Preprint

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Hyperuricemia (HU), characterized by elevated uric acid (UA) levels in the blood, represents a global health concern associated with various conditions, including cardiovascular diseases, gout, hypertension, metabolic syndrome, renal dysfunction, and neurodegenerative diseases. This review offers a contemporary analysis of HU, encompassing its causes, associated health risks, diagnosis, treatment, and future outlook. Recent studies have underscored the multifaceted origin of HU, implicating genetic predisposition, dietary patterns, lifestyle choices, and environmental influences. Genetic variations affecting enzymes and transporters involved in purine metabolism and UA excretion have been identified, laying the groundwork for personalized treatment strategies. Advances in diagnostic imaging and omics technologies provide enhanced precision in the detection and evaluation of risks. While pharmacological interventions remain central to managing HU, persistent challenges such as treatment resistance prompt exploration of novel drug targets and lifestyle modifications. Chinese herbal medicines offer a potentially alternative approach with fewer side effects. Emerging research on the impact of gut microbiota on UA metabolism opens new therapeutic avenues. Despite progress, challenges such as optimizing treatment duration and understanding long-term effects persist. Collaborative efforts are crucial to address these challenges and advance our comprehension of HU. The integration of precision medicine and holistic patient care approaches holds promise for improving outcomes and enhancing quality of life for individuals with HU.

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Section: Treatment Strategiesmentioning

confidence: 99%

Hyperuricemia: Current State and Prospects

Zhang

2024

Preprint

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“…In the past, inhibition of XO activity has been chosen as a pharmacological strategy aimed at the reduction of uric acid and hydrogen peroxide production [ 26 , 36 , 37 ]. This strategy allowed the development of XO inhibitors for the pharmacological treatment of uric acid accumulation diseases [ 5 ], with some of them of natural origin [ 38 ]. However, it has been reported that the use of these substances can cause undesired side effects that hinder their wider therapeutic use [ 26 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage

D’Errico,

Nasso,

Rullo

et al. 2024

Molecules

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Monoamine oxidase and xanthine oxidase inhibitors represent useful multi-target drugs for the prevention, attenuation, and treatment of oxidative damage and neurodegenerative disorders. Chimeric molecules, constituted by naturally derived compounds linked to drugs, represent lead compounds to be explored for the discovery of new synthetic drugs acting as enzyme inhibitors. We have previously reported that seven hydroxytyrosol-donepezil hybrid compounds play a protective role in an in vitro neuronal cell model of Alzheimer’s disease. In this work, we analyzed the effects exerted by the hybrid compounds on the activity of monoamine oxidase A (MAO-A) and B (MAO-B), as well as on xanthine oxidase (XO), enzymes involved in both neurodegenerative disorders and oxidative stress. The results pointed to the identification, among the compounds tested, of selective inhibitors between the two classes of enzymes. While the 4-hydroxy-3-methoxyphenethyl 1-benzylpiperidine-4-carboxylate- (HT3) and the 4-hydroxyphenethyl 1-benzylpiperidine-4-carboxylate- donepezil derivatives (HT4) represented the best inhibitors of MAO-A, with a scarce effect on MAO-B, they were almost ineffective on XO. On the other hand, the 4,5-dihydroxy-2-nitrophenethyl 1-benzylpiperidine-4-carboxylate donepezil derivative (HT2), the least efficient MAO inhibitor, acted like the best XO inhibitor. Therefore, the differential enzymatic targets identified among the hybrid compounds synthesized enhance the possible applications of these polyphenol-donepezil hybrids in neurodegenerative disorders and oxidative stress.

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Preparation of Acetylated Grapefruit Peel Polysaccharide

Huang

2023

Chemistry & Biodiversity

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Grapefruit peel polysaccharide has antioxidant, antitumor, hypoglycemic and other biological activities, and chemical modification can further improve the properties of the polysaccharide. Acetylation modification of polysaccharides has the advantages of simple operation, low cost and little pollution, and is widely used at present. Different degrees of acetylation modification have different effects on the properties of polysaccharides, so it is necessary to optimize the preparation technology of acetylated grapefruit peel polysaccharides. In this article, acetylated grapefruit peel polysaccharide was prepared by acetic anhydride method. With the degree of acetyl substitution as the evaluation index, combined with the analysis of sugar content and protein content in the polysaccharide before and after modification, the effects of three feeding ratios of 1:0.6, 1 : 1.2 and 1 : 1.8 (polysaccharide: acetic anhydride, mass/volume) on acetylation modification were explored through single factor experiments. The results showed that the optimum ratio of material to liquid for acetylation modification of grapefruit peel polysaccharide was 1:0.6. Under these conditions, the degree of substitution of acetylated grapefruit peel polysaccharide was 0.323, the sugar content was 59.50 % and the protein content was 1.038 %. The results provide some reference for the study of acetylated grapefruit peel polysaccharide.

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The Inhibitory Activity of Natural Products to Xanthine Oxidase

Cited by 9 publications

References 123 publications

Hyperuricemia: Current State and Prospects

Hyperuricemia: Current State and Prospects

Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage

Preparation of Acetylated Grapefruit Peel Polysaccharide

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